A5043089796- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Polyamine Metabolism and Applications
- Dermatological diseases and infestations
- Curcumin's Biomedical Applications
- Biochemical effects in animals
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Hydrolysis and Bioactive Peptides
- Study of Mite Species
- Drug Transport and Resistance Mechanisms
- Yersinia bacterium, plague, ectoparasites research
Khon Kaen University
2020-2025
Cholangiocarcinoma (CCA) is often diagnosed late, leading to incomplete tumor removal, drug resistance and reduced chemotherapy efficacy. Curcumin has the potential for anti-cancer activity through various therapeutic properties can improve efficacy of chemotherapy. We aimed investigate synergistic effect a combination curcumin gemcitabine against CCA, targeting LAT2/glutamine pathway. This synergistically suppressed proliferation in gemcitabine-resistant CCA cells (KKU-213B
Cholangiocarcinoma (CCA) or bile-duct cancer is most prevalent in Southeast Asian counties including Thailand. Patients present at an advanced stage when the often drug resistant, leading to chemotherapy failure. Curcumin has therapeutic potential with various anticancer properties. However, its effectiveness limited by low bioavailability, poor solubility, and instability. This study aimed synthesize, characterize evaluate efficacy of curcumin-loaded maltodextrin-based proniosomes (CMPNs)...
Cholangiocarcinoma (CCA) is usually diagnosed at a late stage, leading to treatment failure. Cannabidiol (CBD), exhibits diverse anti-cancer effects in various cancers, offering avenues for improving CCA treatment. This study investigated the of CBD on human cells and underlying mechanisms vitro vivo. The three cell lines (KKU-213B, KKU-100, KKU-055) were assessed using SRB assay, clonogenic extent cell-cycle arrest, 3D holotomography. Morphological changes examined transmission electron...
Head louse infestations remain a global public-health concern due to increased resistance of lice artificial pediculicides. In Thailand, there is lack comparative data on the current efficacy pediculicides for treating head lice. this study, we explored status botanical and toxic synthetic with that 4% dimeticone liquid gel in Thailand. The ex-vivo pediculicidal activity various shampoos available at drugstores Thailand was assessed compared gel. chosen were based active ingredients (1%...
Background/Aim: Forkhead box O4 (FOXO4) has been demonstrated to be a tumor suppressor and proposed as target for treatment of variety cancer types. However, the role FOXO4 in cholangiocarcinoma (CCA), dangerous bile-duct epithelium, rarely explored. Materials Methods: The proliferative rate CCA cell lines KKU-213B, KKU-055 KKK-D068 was investigated using sulforhodamine B (SRB) assay. Levels FOXO4, cyclin E1 (CCNE1), CCNE2, cyclin-dependent kinase 2 (CDK2) division cycle 25A (CDC25A)...
Background Comorbidity of Opisthorchis viverrini (OV) infection and nonalcoholic fatty-liver disease (NAFLD) enhances NAFLD progression to steatohepatitis (NASH) by promoting severe liver inflammation fibrosis. Here, we investigated the effect supplementation with curcumin-loaded nanocomplexes (CNCs) on severity NASH in hamsters. Methodology Hamsters were placed experimental groups as follows: fed standard chow diet (normal control, NC); only high-fat high-fructose (HFF) diet; O . -infected...