Objectives: Oral mucositis is a major cause of pain and delayed cancer treatment leading to poor survival in head neck patients receiving concurrent chemoradiation. The study evaluated the effect adjuvant melatonin on minimizing oral complications reduce these delays interruptions. Design: A randomized, double-blind, double dummy, placebo-controlled clinical trial. Setting: Ubon Ratchathani Cancer Hospital, Thailand. Participants: Thirty-nine chemoradiation (5 days/week radiation plus...

We recently developed a modified solid dispersion of curcumin-loaded nanocomplexes (CNCs) in gums which promoted the prolonged and sustained release curcumin. However, its safety assessment has not yet been investigated. Here, acute chronic toxicities CNCs were assayed using mice hamsters. orally administered to animals. Doses used for toxicity testing 0.1, 1.1, 11.0 g/kg body weight 0.2, 2.1 21.4 0.09, 0.27, 0.8 weight/day 0.18, 0.54 1.61 This regimen was followed daily 6 months. Low medium...

Plants are a rich source of phytochemical compounds with antioxidant activity. Several studies have revealed that the consumption plant polyphenols reduces risk diseases. Purple corn (Zea mays L. variety KND) and butterfly pea (Clitoria ternatea; CT) were selected to be investigated as alternative natural polyphenol sources increase value these plants. Phytochemical profiles activities KND cob, silk, husk CT extracts alone in combination this study. The results purple cob (C) extract had...

Cholangiocarcinoma (CCA) or bile-duct cancer is most prevalent in Southeast Asian counties including Thailand. Patients present at an advanced stage when the often drug resistant, leading to chemotherapy failure. Curcumin has therapeutic potential with various anticancer properties. However, its effectiveness limited by low bioavailability, poor solubility, and instability. This study aimed synthesize, characterize evaluate efficacy of curcumin-loaded maltodextrin-based proniosomes (CMPNs)...

Chitosan or polyvinyl pyrrolidone (PVP) were used in combination with hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (P407) as gelling agents for oral drug delivery. The performance interaction mucin of chitosan-composed gel (F1) PVP-composed (F2) was compared using attenuated total reflectance–Fourier-transform infrared (ATR-FTIR) spectroscopy at controlled temperatures 25 37 °C 1 5 min. F1 containing niosome-entrapped melatonin its derivatives investigated mucoadhesive on mucosa by...

Sericin-alginate hydrogel formulations with purple waxy corn (Zea mays L.) cob extract (PWCC) for topical anti-inflammatory application are developed and evaluated. The physical properties such as viscosity, pH, anthocyanin release examined in vitro activities, NO inhibition IL-6, IL-1β, TNF-α, iNOS, COX-2 expression, evaluated LPS-stimulated RAW 264.7 murine macrophages. sericin-alginate is prepared by crosslinking through the ionic interaction of polymers combined from PWCC at pH 6.5....

The pineal gland is a neuroendocrine organ that plays an important role in anti-inflammation through the hormone melatonin. anti-inflammatory effects of melatonin and its derivatives have been reported both vitro vivo models. Our previous study potent antioxidant neuroprotective activities bromobenzoylamide substituted In silico analysis successfully predicted bromobenzoylamid were protected from metabolism by CYP2A1, which key enzyme process. Therefore, BBM EBM investigated LPS-induced RAW...

Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral (5 mg/kg body weight/day) intranasal PL (7.2 µg/day) randomly assigned to daily administer for 14 days rats which subjected forced swimming, Mor-ris water maze spontaneous motor behavior tests. significantly exhibited anti-depression like activity enhancing effects, comparison the control groups after first dose (p < 0.01) could be maintained throughout period study....

The human liver fluke Opisthorchis viverrini infection and N-nitrosodimethylamine (NDMA) administration induce cholangiocarcinoma (CCA) injury in hamsters. Melatonin protects against reduces the alteration of mitochondrial structure, membrane potential, pro- anti-apoptotic pathways various cancer types. To investigate chemopreventive effect melatonin on CCA genesis injury, hamsters were treated with a combination O. NDMA concurrently administered (10 mg/kg 50 mg/kg) for 120 days. treatment...

Aim: An anthocyanin complex (AC), combined Zea mays and Clitoria ternatea extracts, was evaluated for topical oral wound healing in rats a clinical trial orthodontic patients. Methods/results: AC enhanced permeation vitro. In rats, 10% w/w of mucoadhesive gel (AG) reduced erythema sizes wounds after applications at higher extent than its placebo gel. Acute 68 volunteers were randomly assigned to topically receive either AG or double-blind assessed. Wound size reduction closure enhancement...

This study focuses on the role of photosensitizers in photodynamic therapy. The were prepared combinations 110/220 µM erythrosine and/or 10/20 demethoxy/bisdemethoxy curcumin with/without 10% (w/w) nano-titanium dioxide. Irradiation was performed with a dental blue light 395–480 nm wavelength range, power density 3200 mW/cm2 and yield 72 J/cm2. production ROS hydroxyl radical investigated using an electron paramagnetic resonance spectrometer for each individual photosensitizer or...

Abstract Cancer stem cells (CSCs), a small subpopulation of tumour cells, have properties self‐renewal and multipotency, which drive cancer progression resistance to current treatments. Compounds potentially targeting CSCs been recently developed. This study shows how melatonin, an endogenous hormone synthesised by the pineal gland, its derivative suppress CSC‐like phenotypes human non‐small cell lung (NSCLC) lines, H460, H23, A549. The effects MLT derivative, acetyl melatonin (ACT), on were...

A transmucosal niosome gel was developed to improve the pharmacokinetics of exogenous melatonin.The melatonin niosomes (MN) characterized and levels were determined in healthy volunteers.Micron-sized MN a gel, mean ex vivo residence time more than 3 h with maximum adhesiveness at 25 37°C showed similar vitro release but different permeation gel. Oral gels, 2.5, 5 10 mg, topically applied 14 volunteers randomized double-blinded crossover design 7-day washout, gave dose-proportional...

Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated.A formula of (MN) selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics toxicity studies male Wistar rats.Intranasal MN bioequivalent to intravenous injection melatonin, providing therapeutic level doses. Acute subchronic screening showed no abnormal signs, symptoms or hematological effects any animals. Transient nasal irritations with inflammation were observed intranasal...

This study used polymeric micelles to improve quality by increasing drug solubility, extending mucosal retention time, enhancing mucoadhesiveness, and promoting permeation deposition. Fluocinolone acetonide (FA) was loaded into (FPM), which were composed of poloxamer 407 (P407), sodium polyacrylate (SPA), polyethylene glycol 400, their physicochemical properties examined. Small-angle X-ray scattering (SAXS) revealed a hexagonal micellar structure at all temperatures, the concentrations P407...

At present, the effects of quercetin liposome on anxiolytic activity and cognitive function are unclearly known. In this study, male Wistar rats were administered via intranasal route once daily continually for 4 weeks. The enhancing effect determined after single administration, 1, 2, 3 weeks treatment using elevated plus maze test Morris water respectively. results showed that significantly increased both number opened arm entry time spent in arm. addition, also decreased escape latency...