A5079144670- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cerebral Palsy and Movement Disorders
- Immune cells in cancer
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Balance, Gait, and Falls Prevention
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related Molecular Pathways
- Injury Epidemiology and Prevention
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Extracellular vesicles in disease
- Phytochemical Studies and Bioactivities
- Cytokine Signaling Pathways and Interactions
- Fungal Biology and Applications
- interferon and immune responses
Taipei Medical University-Shuang Ho Hospital
2020-2023
Taipei Medical University
2020-2023
Sorafenib is used for treating advanced hepatocellular carcinoma (HCC), but some patients acquire sorafenib resistance. We investigated the mechanisms underlying acquired resistance in HCC cells and targeted them to re-sensitize sorafenib. In silico analysis indicated that toll-like receptor (TLR)-9 was significantly overexpressed, miRNA (hsa-miR-30a-5p) downregulated sorafenib-resistant cells, which modulated cell proliferation, oxidative stress, apoptosis. TLR9 overexpression increased...
Hepatocellular carcinoma (HCC) is one of the most diagnosed malignancies and a leading cause cancer-related mortality globally. This exacerbated by its highly aggressive phenotype, limitation in early diagnosis effective therapies. The SUMO-activating enzyme subunit 1 (SAE1) component heterodimeric small ubiquitin-related modifier that plays vital role SUMOylation, post-translational modification involving cellular events such as regulation transcription, cell cycle apoptosis. Reported...
Falls represent a global health issue among older adults and cause considerable burden on medical systems. In this study, fall-risk assessment profile was developed for community-dwelling adults.The data of survey participants aged > 65 years were obtained from three rounds (2005, 2009, 2013) the National Health Interview Survey in Taiwan. total, 8356 included study. Logistic regression analyses used to determine potential predictors associated with falls. The coefficients final model...
Background: Hepatitis virus is a major risk factor for liver cancer. The mitochondrial dysfunction IFN gamma-related pathways are activated after infection. Jak family-related protein involved in the downstream of pathways. However, effect IFNGR-JAK-STAT pathway acting as functional regulators their related expression on infection and hepatocellular carcinoma (HCC) remains unclear. Interestingly, role DNA repair gene (PARP1) therapy resistant cancers also has not been studied explored well....
Background. Despite therapeutic advancements, metastasis remains a major cause in breast cancer-specific mortality. Breast cancer cells are susceptible to oxidative damage and exhibit high levels of stress, including protein damage, DNA lipid peroxidation. Some risk factors may change the level endogenous stress. Circulating exosomes play critical roles tumorigenesis, distant metastasis, poor prognosis patients with cancer. Methods. We used an online database analyze expression prognostic...
Abstract Background: Hepatocellular carcinoma (HCC) is one of the most diagnosed malignancies and a leading cause cancer-related mortality globally. This exacerbated by its highly aggressive phenotype, limitation in early diagnosis effective therapies. The SUMO-activating enzyme subunit 1 (SAE1) component heterodimeric small ubiquitin-related modifier that plays vital role SUMOylation, post-translational modification involving cellular events such as regulation transcription, cell cycle...
Abstract The authors have requested that this preprint be removed from Research Square.