A5043431653- Colorectal Cancer Treatments and Studies
- Cardiac Arrhythmias and Treatments
- Pancreatic and Hepatic Oncology Research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Atrial Fibrillation Management and Outcomes
- Transplantation: Methods and Outcomes
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
Massachusetts General Hospital
2018-2025
Peter MacCallum Cancer Centre
2025
The University of Melbourne
2025
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Cedars-Sinai Medical Center
2014-2024
Virginia Oncology Associates
2016-2023
Northwell Health
2019-2023
Feinstein Institute for Medical Research
2020-2022
The University of Texas MD Anderson Cancer Center
2005-2021
The primary goal of this study was to evaluate whether pathologic response chemotherapy predicts patient survival after preoperative and resection colorectal liver metastases (CLM). secondary the identify clinical predictors response.A retrospective review performed 305 patients who underwent irinotecan- or oxaliplatin-based chemotherapy, followed by CLM. Pathologic systematically evaluated reported as mean percentage cancer cells remaining within each tumor. Univariate multivariate analyses...
Abstract BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine‐plus‐oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on pathologic response and nontumorous histology. METHODS. A total 105 consecutive patients treated preoperatively with 5FU/OX (n = 62) or without 43) were analyzed. was by analysis tumor viability (percentage viable in relation surface area). incidence grade hepatic sinusoidal dilation also investigated. RESULTS....
The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global disease 2019 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine±azithromycin treatment 2019. Use these medications alone, or in combination, can lead to prolongation QT interval, possibly increasing risk Torsade de pointes and sudden cardiac death.
Huachansu, a Chinese medicine that comes from dried toad venom the skin glands of Bufo gargarizans or B. melanostictus, has been used in treatment various cancers China. The authors conducted pilot study, using phase 1 trial design, huachansu patients with advanced cancer.Huachansu was administered intravenously for 14 days followed by 7 off (1 cycle). Without significant adverse events progressive disease, continued beyond 2 cycles. dose escalated as follows 3 per cohort: 10 (level 1), 20...
Anti-programmed cell death protein 1 antibodies plus multikinase inhibitors have shown encouraging activity in several tumour types, including colorectal cancer. This study assessed regorafenib nivolumab patients with microsatellite stable/mismatch repair-proficient metastatic cancer.This single-arm, open-label, multicentre phase 2 enrolled adults from 13 sites the USA previously treated advanced Eligible had known extended RAS and BRAF status, progression or intolerance to no more than two...
Abstract Purpose: We investigated the role of human endogenous retrovirus type K (HERV-K) envelope (env) gene in pancreatic cancer. Experimental Design: shRNA was employed to knockdown (KD) expression HERV-K cancer cells. Results: env detected seven cell lines and 80% patient biopsies, but not two normal or uninvolved tissues. A new splice variant discovered several lines. Reverse transcriptase activity virus-like particles were observed culture media supernatant obtained from Panc-1 Panc-2...
First described in the 1990s, Brugada syndrome initially characterized unexplained sudden cardiac death healthy Southeast Asian men.1 Mutations sodium channel were later identified SCN5A and SCN10A genes, accounting for nearly 50% of cases.2,3 phenotype is associated with decrease current owing to reduction channels and/or function channels. Although manifests characteristic electrocardiographic abnormalities, patients are often unaware their genetic predisposition.
3560 Background: The role of immunotherapy in the treatment pMMR/MSS metastatic CRC is not established. A Japanese phase 1b trial this setting showed combination regorafenib (multikinase inhibitor with immunomodulatory activity) plus nivolumab (anti PD-1) had encouraging activity and manageable safety (Fukuoka, 2020). This study further assessed efficacy combination. Methods: Patients (pts) from US aged ≥18 years who progressed on/were intolerant to standard chemotherapy were enrolled....
Abstract Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition. However, it is unknown whether a combination these two compounds results in synergistic inhibitory effect on pancreatic cancer growth and/or has therapeutic advantage over gemcitabine. In xenograft mouse models human cancer, treatment with either BA or MIT alone showed dose-dependent but led to systemic side effects as measured by overall weight loss....
An intravenous formulated extract of the venom wild toad Bufo bufo gargarizans Cantor or melanostictus Schneider, huachansu, is currently used in China for treatment lung, liver, pancreatic, and colorectal cancers. We performed a randomised, single-blinded, phase II clinical study huachansu plus gemcitabine versus placebo patients with locally advanced and/or metastatic pancreatic adenocarcinomas.Patients tissue-proven adenocarinoma were randomly assigned to receive either 1000 mg m(-2) on...
Sleep disturbances and fatigue are common in prostate cancer patients undergoing radiotherapy. Prior research suggests mind-body techniques may improve these outcomes. We conducted a randomized controlled trial of qigong/tai chi (QGTC) men with radiotherapy.Men starting definitive radiation were to 1 3 groups: (1) QGTC; (2) light exercise (LE); or (3) waiting list control. (Pittsburgh Quality Index) (Brief Fatigue Inventory) assessed at baseline, midway through radiotherapy (T2), during the...
Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of transcription factor Sp1. In present study, we investigated whether pancreatic cancer treatment with a combination these compounds has synergistic effect on Sp1 activity, tumor growth, their underlying response mechanisms. Treatment xenografts MIT TA produced dose-dependent antitumor significant either compound alone was directly associated systemic side effects. Combination nontoxic doses both whereas dose lacked discernible...
The aim of this study was to determine whether checkpoint kinase 1 inihibitor (CHK1), LY2603618, and gemcitabine prolong overall survival (OS) compared alone in patients with unresectable pancreatic cancer.Patients Stage II-IV locally advanced or metastatic cancer were randomized (2:1) either 230 mg LY2603618/1000 mg/m2 combined 1000 alone. OS assessed using both a Bayesian augment control model traditional frequentist analysis for inference. Progression-free (PFS), response rate (ORR),...
Abstract Introduction The need for transvenous lead extractions due to cardiac implantable electronic device (CIED)‐related infections continues rise. Current guidelines recommend complete removal in the setting of an active infection, which can be challenging pacemaker‐dependent patients. Methods We retrospectively reviewed all leadless pacemaker implants between January 2018 and November 2019 identified a subset patients who had undergone concomitant CIED extraction infection. Baseline...
Metastasis-directed therapy (MDT) in oligometastatic renal cell carcinoma (RCC) is typically based on conventional imaging. Prostate-specific membrane antigen (PSMA) PET/CT has shown superiority over Our objective was to perform a proof-of-concept study evaluate the efficacy of PSMA-guided MDT RCC. Methods: A PSMA database queried for RCC patients undergoing from 2014 2020. The primary endpoint progression-free survival. Secondary endpoints included freedom local progression, change systemic...
Abstract Purpose: To determine whether the synthetic microRNAs (miRNA) could effectively target tumor cells we designed several miRNA complementary to glioma-associated antigen-1 (Gli-1) mRNA and investigated their ability inhibit cell proliferation. The sonic hedgehog pathway is an early late mediator of tumorigenesis in epithelial cancers. Activation signaling seems precede transformation tissue stem cancerous cells, with Gli-1 transcription factor functioning as a environmental signals....
Abstract Genetic variation in DNA repair may affect the clinical response to cytotoxic therapies. We investigated effect of six single nucleotide polymorphisms RecQ1, RAD54L, XRCC2, and XRCC3 genes on overall survival 378 patients with pancreatic adenocarcinoma who were treated at University Texas M.D. Anderson Cancer Center during February 1999 October 2004 followed up 2005. Genotypes determined using MassCode method. Survival was from pathologic diagnosis death. Patients alive last...
To explore the utility of multidisciplinary approaches in treatment patients with pancreatic cancer liver metastases (PCLM).From 2002 to 2007, a total 164 consecutive PCLM treated chemotherapy, radiation therapy, and/or Chinese herbal medicine were included this study. Clinical parameters, treatments received, and survival time from initial diagnosis analyzed.Of patients, 113 (69%) men 51 (31%) women, median age 58 years. One hundred thirty-two (80%) had synchronous metastases, 57 (35%)...
The current COVID-19 pandemic has placed extreme stress on the global health care system. Novel approaches to managing COIVD-19 patients are required. Preliminary results from a small trial suggest that combination of hydroxychloroquine and azithromycin is efficacious for reducing viral load in with COVID-19.1 Although arrhythmogenic risk these medications low, both alone, combination, can prolong QT interval.1–7 Patients receiving this regimen require, at minimum, serial electrocardiograms...