A5089940988- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Radiotherapy Techniques
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2022-2025
Azienda Ospedaliero Universitaria Maggiore della Carita
2022-2025
Department of Medical Sciences
2024-2025
IRCCS Humanitas Research Hospital
2015-2024
Humanitas University
2015-2024
Collaborative Group (United States)
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2023
Carilion Clinic
2020
Jackson and Tull (United States)
2020
Virginia Tech
2020
Abstract Background This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, subsequent effects outcome after resection. Methods Records 112 patients were reviewed. Standardized FLR (sFLR) degree hypertrophy (DH; difference between sFLR before PVE), complications outcomes analysed to determine cut-offs that predict postoperative hepatic dysfunction. Results Ten (8·9 per cent) had PVE-related complications....
The aim of this study was to investigate in a retrospective setting the patients' profile and results those undergoing surgery for hepatocellular carcinoma (HCC) high-volume surgical centers throughout world.Whether HCC is suitable approach which subset patients still controversial. EASL/AASLD (European Association Study Liver Disease/American Disease) guidelines, based on Barcelona Clinic Cancer (BCLC) classification, leave little room hepatic resection; inversely, other reports promote its...
Abstract BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine‐plus‐oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on pathologic response and nontumorous histology. METHODS. A total 105 consecutive patients treated preoperatively with 5FU/OX (n = 62) or without 43) were analyzed. was by analysis tumor viability (percentage viable in relation surface area). incidence grade hepatic sinusoidal dilation also investigated. RESULTS....
We investigated the clinical significance of a vascular growth pattern hepatocellular carcinoma (HCC), vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination. VETC was assessed in large multi‐institutional cohort 541 resected HCCs from Italy, Korea and Japan, matched against full spectrum pathological variables. The phenotype (defined as ≥ 55% area by CD34 immunostaining) easily reproducible reliably detectable whole sections small‐sized tissues...
Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears be a major unfavorable feature of hepatocellular carcinoma (HCC). The members IAP family are key regulators apoptosis, cytokinesis signal transduction. survival action is antagonized by specific binding Smac/DIABLO XAF1. This study aimed investigate the gene protein expression pattern their antagonists in series human HCCs assess clinical significance.Relative quantification...
It has long been known that in vitro polarized macrophages differ morphology. Stemming from a conventional immunohistology observation, we set out to test the hypothesis morphology of tumor-associated (TAMs) colorectal liver metastasis (CLM) represents correlate functional diversity with prognostic significance. Density and morphological metrics TAMs were measured correlated clinicopathological variables. While density did not survival CLM patients, cell area identified small (S-TAM) large...
To analyze the impact of COVID-19 emergency on elective oncological surgical activity in Italy.COVID-19 shocked national health systems, subtracting resources from treatment other diseases. Its oncology is still to elucidate.A 56-question survey regarding Italy during was sent referral centers for hepato-bilio-pancreatic, colorectal, esophago-gastric, and sarcoma/soft-tissue tumors. The portrays situation 5 weeks after first case secondary transmission Italy.In total, 54 Units 36 Hospitals...
Abstract Patients with colorectal liver metastasis (CLM) present heterogenous clinical outcomes and improved classification is needed to ameliorate the therapeutic output. Macrophages (Mϕ) hold promise as prognostic classifiers targets. Here, stemming from a single-cell analysis of mononuclear phagocytes infiltrating human CLM, we identified two Mϕ markers associated distinct populations opposite relevance. The invasive margin CLM was enriched in pro-inflammatory monocyte-derived (MoMϕ)...
Intraoperative ultrasonography (IOUS) may allow a more conservative procedure in patients with liver tumours involving hepatic vein at the caval confluence. The aim of this study was to determine whether IOUS and colour Doppler might reduce rate major hepatectomy vascular reconstruction such tumours.Of 133 consecutive tumour who underwent hepatectomy, 22 had involvement surgical strategy employed determined by findings relationship between vein, presence accessory veins, portal flow as...
Anatomic resection is considered the gold standard approach for liver in patients with hepatocellular carcinoma. The use of intraoperative ultrasound (IOUS) as guidance indispensable this sense but methods available up to now were rather complex and that reason limited use. We herein describe a novel technique demarcation area by means IOUS-guided finger compression systematically accomplish anatomic segmental subsegmental resections.Thirty-three met eligibility criteria. This consisted...