Alessandro Zerbi
A5072356061- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Body Composition Measurement Techniques
IRCCS Humanitas Research Hospital
2016-2025
Humanitas University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2025
Fondazione Poliambulanza Istituto Ospedaliero
2024
Pancreas Centre (Canada)
2020-2023
University of Verona
2010-2023
Oslo University Hospital
2023
Ospedale G.B. Morgagni - L.Pierantoni
2023
University of Bologna
2010-2023
University of Milan
1994-2021
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
Abstract Background Data on enhanced recovery programmes after pancreatic surgery are sparse. This retrospective cohort study, using historical controls, aimed to evaluate the impact of a fast-track programme pancreaticoduodenectomy (PD). Methods Between 2004 and 2007, 252 patients undergoing PD were treated by that included earlier postoperative feeding mobilization. The compared with an equally sized control group received traditional from 2000 2004. Outcome measures morbidity, length stay...
Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open (ODP) in patients pancreatic ductal adenocarcinoma (PDAC). Background: Cohort studies have suggested superior short-term MIDP vs. ODP. Recent international surveys, however, revealed that surgeons concerns about the for PDAC. Methods: This is a pan-European propensity score matched including who underwent (laparoscopic or robot-assisted) ODP PDAC between...
Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising prospect their targeting human cancer.In a large retrospective cohort study involving 110 patients with pancreatic ductal adenocarcinoma (PDAC), we assessed density CD68-TAM immune reactive area (%IRA) at tumour-stroma interface and addressed prognostic relevance relation to postsurgical adjuvant chemotherapy (CTX). In...
B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role B lymphocytes in microenvironment human pancreatic ductal adenocarcinoma (PDAC), a retrospective consecutive series 104 PDAC patients and preclinical models. Immunohistochemical analysis revealed that cells occupy two histologically distinct compartments PDAC, either scatteringly infiltrating (CD20-TILs), or organized tertiary lymphoid tissue (CD20-TLT). Only when retained...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Objective: To develop and update evidence- consensus-based guidelines on laparoscopic robotic pancreatic surgery. Summary Background Data: Minimally invasive surgery (MIPS), including surgery, is complex technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines. Since International Miami Guidelines MIPS in 2019, new developments key publications have been reported, necessitating an update. Methods: Evidence-based 22 topics 8 domains were proposed:...
Abstract In this study, we have evaluated 11 pancreatic tumor cell lines and cells from surgical samples of patients with adenocarcinoma for expression the chemokine receptor CXCR4. Six expressed detectable mRNA CXCR4, three (AsPC1, Capan1, Hs766T) having substantial amounts transcripts. Expression was higher in derived metastatic lesions compared those primary tumors. Different inflammatory cytokines did not modify expression, whereas IFN-γ down-regulated hypoxia up-regulated CXCR4...
Abstract Background An inverse relationship between hospital volume and death following pancreatico duodenectomy (PD) has been reported from several countries. The aim of this study was to assess the volume–outcome effect PD in Italy. Methods group comprised 1576 patients who underwent 2003. Hospitals were allocated four groups: low volume, five PDs or fewer; medium six 13 PDs; high 14 51 very two hospitals that performed 89 104 PDs. Results Some 221 at least one 2003; 74·7 per cent, 17·6...
Abstract Tumor perineural dissemination is a hallmark of human pancreatic ductal adenocarcinoma (PDAC) and represents major source local tumor recurrence after surgery. In this study, we provide in vitro vivo evidence that the chemokine receptor CX3CR1 may be involved neurotropism PDAC cells to peripheral nerves. Neoplastic from cell lines surgical specimens express CX3CR1, absent normal ducts. Its unique ligand, transmembrane CX3CL1, expressed by neurons nerve fibers. + migrated response...
<h3>Objective</h3>To analyze the characteristics and outcomes following enucleation pancreatic resections of insulinomas.<h3>Design</h3>Retrospective cohort study; prospective database.<h3>Settings</h3>Academic, tertiary, referral centers.<h3>Patients</h3>Consecutive patients with insulinomas (symptoms hyperinsulinism positive fasting glucose test) who underwent surgical treatment between January 1990 December 2009.<h3>Main Outcome Measures</h3>Operative morbidity, tumor recurrence, survival...
OBJECTIVES: Information on pancreatic endocrine tumors (PETs) comes mostly from small, retrospective, uncontrolled studies conducted highly selected patients. The aim of the study was to describe clinical and pathological features PETs in a prospective, multicenter study. METHODS: Newly diagnosed, histologically proven, sporadic observed June 2004 March 2007 24 Italian centers were included specific data set. RESULTS: Two hundred ninety-seven patients (mean age 58.6±14.7 years, females...