A5005157511- Extracellular vesicles in disease
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- S100 Proteins and Annexins
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Glaucoma and retinal disorders
- Neuroendocrine Tumor Research Advances
Gyeongsang National University
2016-2025
Changwon National University
2017-2025
Gyeongsang National University Hospital
2015-2023
Weatherford College
2022
Samsung Medical Center
2013-2015
Sungkyunkwan University
2013-2015
St. Paul's Hospital
2015
Catholic University of Korea
2015
Armed Forces Capital Hospital
2013-2014
University of Miami
1992
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
Recently, researchers have tried to predict patient prognosis using biomarker expression in cancer patients. The aim of this study was develop a nomogram predicting the 5-year recurrence-free probability (RFP) gastric patients prognostic gene expression.We enrolled 360 training data set predictive model and nomogram. We analyzed patients' general variables levels 10 candidates between nonrecurrence recurrence groups. also performed external validation 420 from set.The final composed age,...
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes and its prevalence a serious growing clinical problem. Caloric restriction (CR) commonly recommended for improvement obesity-related diseases such as NAFLD. However, effects CR on hepatic metabolism remain unknown. We investigated metabolic dysfunction in obese diabetic db/db mice. found that mice reverted insulin resistance, steatosis, body weight adiposity to those db/m 1 H-NMR- UPLC-QTOF-MS-based...
Background/Aim: Metabolic dysfunction–associated steatotic liver disease (MASLD) is a serious global public health concern. Long non-coding RNAs (lncRNAs) have been identified as key contributors to MASLD pathogenesis. Zebrafish can be utilized study the relationship between and lncRNAs because of their similarity human genes. Oil Red O staining traditional method for confirming fatty changes; however, it has several limitations. This aimed evaluate efficacy boron-dipyrromethene (BODIPY) in...
Ribonucleotide reductase subunit M2 (RRM2) catalyzes the production of deoxynucleotide triphosphates, which are necessary for DNA synthesis. RRM2 has been reported to play an active role in tumor progression, and elevated levels have correlated with poor prognosis colorectal cancer patients. This study aimed elucidate prognostic significance protein expression hepatocellular carcinoma after surgery.RRM2 was evaluated using immunohistochemistry tissues from 259 patients who underwent curative...
The prognostic impact of the expression CD8 and programmed death-ligand 1 (PD-L1) has not been established in patients with resectable non-small cell lung cancer (NSCLC).Surgical tissue specimens were obtained from 136 NSCLC who underwent surgical resection. levels PD-L1 assessed using microarrays immunohistochemistry.The CD8-positive group showed significant increases overall survival (OS) (median, reached [NR] vs. 28.452 months) relapse-free (RFS) NR 14.916 compared CD8-negative group. In...
Abstract We aimed to quantitatively analyze the exosome and its cargo in individual aqueous humor (AH) samples from pseudoexfoliation (PEX) glaucoma patients compared controls using a novel detection platform. investigated size distribution measured quantitative particle counts each AH sample. (80–120 µL) was obtained during cataract surgery or filtering 12 Korean subjects (six with PEX six age-matched controls). The mean of exosomes 58.9 ± 18.5 nm by tangential flow filtration system...
Upregulation of aldo-keto reductase 1B10 (AKR1B10) through the mitogenic activator protein-1 signaling pathway might promote hepatocarcinogenesis and tumor progression. The goal this study was to evaluate prognostic significance AKR1B10 protein expression in patients with hepatocellular carcinoma after surgery.
Myoferlin is a protein that associated with cellular repair following injury. The expression of myoferlin in breast cancer and pancreatic adenocarcinoma has been reported to correlate tumor invasiveness, epithelial mesenchymal transition an adverse prognosis. In the present study, was investigated non-small cell lung carcinoma (NSCLC), along its association patient prognosis number other proteins. A total 148 patients exhibiting NSCLC were enrolled study. survival data all examined,...
Background Rab27A and Rab27B are the major components of vesicle fusion trafficking in exosome secretion play important roles tumor progression metastasis. In addition, associated with prognosis. This study investigated prognostic expression patients non‐small cell lung cancer (NSCLC). Methods was assessed 133 cases NSCLC by immunohistochemistry. We evaluated correlations between clinicopathological data determined their role NSCLC. Results were significantly related to patient gender ( P =...
We aimed to identify and compare microRNAs (miRNAs) from individual aqueous humor samples between normal-tension glaucoma (NTG) patients normal controls. Aqueous (80 120 µl) was collected before cataract surgery. Six stable NTG seven age-matched controls were included in the final analysis. RNA sequencing conducted for extracted 13 samples, bioinformatics analysis employed miRNA targets related pathways. Two hundred twenty-eight discrete miRNAs detected consistently expressed all samples....
Abstract Background The exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator exosome secretion. For metastatic renal cell carcinoma (RCC), this study examines the mechanisms cancer metastasis via RAB27A-regulated specific miRNAs. Methods knockdown (KD) overexpressing (OE) RCC cells were used to examine migration adhesion. particle counts sizes exosomes OE analyzed using Exoview, those intraluminal vesicles (ILV) multivesicular bodies...
Molecular and transcription factor subtyping were recently introduced to identify patients with unique clinical features in small cell lung cancer (SCLC). However, its prognostic relevance is yet be established. This study aims investigate the implications significance of SCLC using immunohistochemistry.
Melanin is a natural pigment that plays an important role in the protection of skin, however, hyperpigmentation cause by excessive levels melatonin associated with several problems. Therefore, melanogenesis inhibitory products have been developed cosmetic industry as skin medications. The leaves Morus alba (Moraceae) reported to inhibit melanogenesis, therefore, characterization constituents M. was attempted this study. Twenty compounds including eight benzofurans, 10 flavonoids, one...
Left atrial (LA) fibrosis caused by various pathological stimuli is a common finding. However, the difference of remodelling via haemodynamic change in diverse cardiomyopathy has not been elucidated. Male Sprague-Dawley rats (6–8 weeks, n = 180) were randomly assigned to three groups and corresponding sham control groups: (i) ischaemic cardiomyopathy, (ii) left ventricular hypertrophy (LVH), (iii) dilated cardiomyopathy. At 12 weeks after operation, fibrillation (AF) inducibility duration...
// Dae Hyun Song 1, 2, 4 , Gyung Hyuck Ko 3 Jeong Hee Lee Jong Sil Jung Wook Yang Min Hye Kim Hyo An Myoung Kang 5 Kyung Nyeo Jeon 6 and Dong Chul 1 Gyeongsang National University School of Medicine, Jinju, South Korea 2 Institute Health Science, University, Department Pathology, Hospital, Changwon Changwon, Internal Radiology, Correspondence to: Kim, email: kdcjes@gmail.com Keywords: clear cell renal carcinoma, myoferlin, prognosis, disease-free survival, immunohistochemistry Received: July...
Peroxiredoxin IV (PRDX4) is a multifunctional protein that involved in cell protection against oxidative injury, regulation of proliferation, modulation intracellular signaling, and the pathogenesis tumors. We previously conducted proteomic analysis to investigate tumor‑specific expression gastric cancer. The aim present study was whether PRDX4 could be marker poor prognosis patients with Immunohistochemistry used validate as prognostic for Short hairpin RNA (shRNA)‑mediated knockdown AGS...
RAB27A and RAB27B are involved in exosome secretion. To date, there have been many attempts to elucidate the roles of prognosis various cancer types. The association expression with clinical pathological features was evaluated patients stomach cancer.
Radiation-induced lung injury (RILI) is a common and unavoidable complication of thoracic radiotherapy. The current study was conducted to evaluate the ability clarithromycin (CLA) prevent radiation-induced pneumonitis, oxidative stress, fibrosis in an animal model. C57BL/6J mice were assigned control, irradiation only, plus CLA, CLA only groups. Test received single exposures radiation and/or oral (100 mg/kg/day). Histopathologic findings markers inflammation, fibrosis, stress compared by...