A5031275956- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Salivary Gland Tumors Diagnosis and Treatment
Pusan National University
2013-2025
Pusan National University Hospital
2014-2024
Brigham and Women's Hospital
2024
Harvard University
2024
Pusan National University Yangsan Hospital
2024
Government of the Republic of Korea
2023
Statistical Research (United States)
2019
Busan National University of Education
2019
Computational pathology
Gastric cancers have recently been classified into several types on the basis of molecular characterization, and new taxonomy has shown to clinical relevance. However, technology required for thorough classification is complicated expensive, currently preventing widespread use. We aimed reproduce results using only simple techniques, that is, immunohistochemical analysis in situ hybridization. a cohort 349 successive gastric adenocarcinomas 5 subtypes, protein or mRNA expression MLH1,...
Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated favorable prognosis. However, the significance of effect MSI on clinicopathological features, as well its association mucin phenotype, remains unclear.MSI status was assessed in 414 cases gastric cancer using polymerase chain reaction analysis five loci, recommended by National Cancer Institution criteria. The expression mucins (MUC5AC, MUC6, MUC2, and CD10) assessed.Out total cancer, 380 (91.7%), 11...
Abstract Immunotherapy targeting PD-1/PD-L1 axis showed benefits in cancer. Prognostic significance of tumour infiltrating lymphocytes (TILs) has been determined. We evaluated PD-L1 protein expression cells and TILs, mRNA level various histopathologic factors including TILs using 167 formalin-fixed paraffin embedded tissues 39 fresh tissue HER2-positive breast were significantly correlated one another. positivity was associated with high histologic grade (p < 0.001, both). High...
// Chae Hwa Kwon 1 , Hye Ji Park Yu Ri Choi Ahrong Kim Won Jin Chung Su Hwang So Jung Lee Chang In 2 Tae Yong Jeon Dae Hwan Gwang Ha 3 and Do Youn Department of Pathology, Pusan National University Hospital School Medicine, BioMedical Research Institute, Hospital, Seo-Gu, Busan, Korea Surgery, Internal Correspondence to: Park, email: Keywords : stomach, adenocarcinoma, prognosis, PSMB8, PBK Received August 10, 2015 Accepted February 05, 2016 Published 15, Abstract Gastric adenocarcinoma is a...
Genome-wide next-generation sequencing has revealed several driver mutations and allowed the establishment of a molecular taxonomy gastric cancer. However, there are few detailed studies on mutational spectrum poorly cohesive carcinoma. Thus, this study aim to investigate its mutation profile based clinicopathological characteristics.Herein, we analysed pattern 77 genes in cohort 91 patients with carcinoma by using targeted sequencing, evaluated significance various histological pattern,...
PD-L1 expression levels determined by immunostaining are known to be related the survival rate and prognosis of patients with various types cancers, as well therapeutic response immune checkpoint inhibitors. Recently, U.S. Food Drug Administration approved an inhibitor for treatment non-small cell lung cancer along clones used predict resulting response. In this study, we performed tissue microarrays from ovarian epithelial using SP263, clone, examined effect on prognosis.Tissue were...
The prognostic significance of tumor-infiltrating lymphocytes has been determined in cancers the lung, colon and breast, though there is no standardized method for using this indicator lung cancer. We applied a modified version proposed by International Immuno-Oncology Biomarkers Working Group to primary adenocarcinoma, which uses histologic findings hematoxylin eosin sections. study included total cohort 146 adenocarcinoma patients who underwent lobectomy with lymph node dissection at two...
AIM:To predict the rate of lymph node (LN) metastasis in diffuse-and mixed-type early gastric cancers (EGC) for guidelines treatment.
Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia 10%). Other than brain tumor or hematologic malignancies, intrahepatic cholangiocarcinoma (iCC) a well-known solid with IDH1 (6.8–20%). Histologically, poor differentiation clear cell change are associated iCC. Since hepatocellular carcinoma (HCC) shares histologic features iCC, some specific subtypes of HCC might show higher rate reported before (0.5–1.5%). Forty-six cases...
We tried to describe cellular immune response (tertiary lymphoid structures (TLSs), aggregates, tumor infiltrating lymphocytes (TILs)) in neoplastic microenvironment of ductal carcinoma situ (DCIS) with or without associated microinvasion.The histopathologic parameters 177 DCIS and 27 microinvasion were evaluated. determined number ducts involved by DCIS, calculated percentage these surrounded TLSs. TILs quantitated microinvasive cases.Tumors having higher TLSs had incidence (P < .001)....
Purpose Notable effectiveness of trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2 (HER2)–low advanced breast cancer (BC) has focused pathologists’ attention. We studied the incidence and clinicopathologic characteristics HER2-low BC, effects immunohistochemistry (IHC) associated factors on HER2 IHC results.Materials Methods The Breast Pathology Study Group Korean Society Pathologists conducted a nationwide study using real-world data status generated between...
Spatial transcriptomics (ST) enables interrogating the molecular composition of tissue with ever-increasing resolution, depth, and sensitivity. However, costs, rapidly evolving technology, lack standards have constrained computational methods in ST to narrow tasks small cohorts. In addition, underlying morphology as reflected by H&E-stained whole slide images (WSIs) encodes rich information often overlooked studies. Here, we introduce HEST-1k, a collection 1,108 spatial transcriptomic...
Venous invasion (VI) is widely accepted as a poor prognostic factor in colorectal cancer (CRC), and indicated high-risk determining the use of adjuvant chemotherapy CRC. However, there marked interobserver intraobserver variability VI identification real prevalence CRC.We investigated detection rate 93 consecutive cases T3 or T4 CRC based on following: original pathology report, review hematoxylin eosin (H&E) slides with attention to "protruding tongue" "orphan arteriole" signs, elastic...
High mobility group box 1 (HMGB1) is a prototypic alarmin or damage‐associated molecule inducing inflammatory mediator release and immune response. Several studies have revealed the prognostic predictive importance of tumor‐infiltrating lymphocytes (TILs) in breast cancer. The present study analyzed expression HMGB1 each cancer subtype relationship between level pathologic parameters including TILs. Two cohorts were studied: 575 consecutive patients who underwent surgery 1995 1998; 767...
High‑grade soft‑tissue sarcoma (STS) is a highly malignant neoplasm with poor overall prognosis. Numerous prognostic factors determine tumor progression and patient outcomes. Various immune‑associated cells identified in the microenvironment have important roles various types. The present study was performed to evaluate expression of genes elucidate association between these prognosis high‑grade STS. A total 12 formalin‑fixed, paraffin‑embedded tissue samples STS were subjected gene analysis...
Purpose The programmed death ligand 1 (PD-L1) SP142 assay with a 1% immune cell (IC) cutoff is approved for the selection of advanced triple-negative breast cancer (TNBC) patients atezolizumab treatment. We aimed to evaluate interobserver concordance PD-L1 scoring and inter-assay variability various assays in TNBC. Methods Thirty primary TNBC were selected, SP142, SP263, 22C3, E1L3N performed. staining ICs tumor cells (TCs) was scored by 10 pathologists who blinded assay. among four...
We evaluated the frequency of translocation renal cell carcinoma (RCC) by reverse transcription polymerase chain reaction (RT-PCR) and how well TFE3 immunoreactivity is concordant with gene status proved fluorescence in situ hybridization (FISH) assay RT-PCR. Cathepsin K expression was analyzed immunohistochemistry 185 RCC cases, 48 cases either more than weak or positivity for were done FISH analysis All RT-PCR positive confirmed cloning sequencing. Of 14 strong nuclear expression, 12...
Abstract Programmed death ligand 1 (PD-L1) immunohistochemistry (IHC) assays are widely used for complementary or companion diagnostic purposes during treatment with immune checkpoint inhibitors. However, limited information is available on the clinical reliability of PD-L1 IHC assay using small biopsy samples. Participants included 46 patients nonsmall cell lung cancer who underwent testing 3 (22C3, SP142, and SP263) both samples surgical specimens from November 2017 to June 2018. The...