A5079274644- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive Biology and Fertility
- Chromosomal and Genetic Variations
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Renal and related cancers
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Ovarian function and disorders
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Biosensors and Analytical Detection
- Neuroblastoma Research and Treatments
- Gynecological conditions and treatments
- Cancer Research and Treatments
Pusan National University
2016-2025
Pusan National University Hospital
2015-2024
Weatherford College
2024
Samsung Medical Center
2023
Sungkyunkwan University
2023
Seoul National University Hospital
2023
CHA Bundang Medical Center
2023
CHA University
2023
Daegu Catholic University Medical Center
2023
Hallym University Kangnam Sacred Heart Hospital
2023
Here we report the development of a programmable and fully automatic gold array-embedded gradient microfluidic chip that integrates device with gold-patterned microarray wells. This provides convenient reproducible surface-enhanced Raman scattering (SERS)-based immunoassay platform for cancer biomarkers. We used hollow nanospheres (HGNs) as SERS agents because their highly sensitive characteristics. The utility this was demonstrated by quantitative alpha-fetoprotein (AFP) model protein...
Objective: To measure the prognostic value of lymphocyte-monocyte ratio (LMR) in patients with epithelial ovarian cancer (EOC).Methods: We retrospectively examined LMR as a prognosticator cohort 234 EOC who underwent surgical resection.Patients were categorized into two different groups based on (LMR-low and LMR-high) using cut-off values determined by receiver operating characteristic (ROC) curve analysis.The objective study was to assess effect progression-free survival (PFS) overall (OS),...
Silver-coated magnetic microspheres (Fe3O4/Ag core/shell) were fabricated for use as a surface-enhanced Raman scattering (SERS) substrate. The surface morphology of the was characterized via field emission scanning electron microscopy and transmission microscopy. Energy-dispersive spectroscopy also employed to analyze elemental composition structures. Malachite green used model analyte evaluate performance SERS-active substrate validate SERS effect. prepared possessed both properties. In...
Amorphous silicon (a-Si) was crystallized by metal-induced crystallization (MIC) using a Ni standard absorption solution. The a-Si films spin-coated with 5000 ppm solution were at as low 500 °C. Needlelike morphology, developed result of the migration NiSi2 precipitates, appears in MIC poly-Si. growth needlelike crystallites proceeds to direction parallel 〈111〉. can be fully °C for 20 h.
The present study was undertaken to determine the underlying mechanism of silibinin-induced cell death in human breast cancer lines MCF7 and MDA-MB-231. Silibinin-induced attenuated by antioxidants, <i>N</i>-acetylcysteine (NAC) 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, suggesting that effect silibinin dependent on generation reactive oxygen species (ROS). Western blot analysis showed induced downregulation extracellular signal-regulated kinase (ERK) Akt. When cells were...
Toll-like receptors (TLR) are a family of pattern recognition that constitutes major part the innate immune system. The TLR4/(Myeloid differentiation factor 88 (MyD88) signaling pathway has been shown to have oncogenic effects.To demonstrate role TLR4/MyD88 in ovarian epithelial cancers (OECs), we examined expression TLR4, MyD88 and nuclear factor- κB (NF-κB) OECs. MyD88, NF-κB was detected by immunohistochemistry, relationships between these clinicopathologic features 123 cases OECs were...
The flavonoid, luteolin, has been shown to have anticancer activity in various cancer cells; however, the precise molecular mechanism of its action is not completely understood, and studies were conducted find out how it induces apoptosis breast cells. Luteolin induced a reduction viability dose- time-dependent manner. pro-apoptotic effect luteolin was demonstrated by cell cycle measurement Hoechst 3325 staining. Western blot analysis showed that activates ERK (extracellular-signal-regulated...
The use of silica shells offers many advantages in surface-enhanced Raman scattering (SERS)-based biological sensing applications due to their optical transparency, remarkable stability environmental media, and improved biocompatibility. Here, we report a novel layer-by-layer method for the preparation silica-hollow gold nanosphere (HGN) SERS tags. Poly(acrylic acid) was used stabilize reporter-tagged HGNs prior adsorption coupling agent, after which shell deposited onto particle surface...
Objective:We assessed the prognostic implications of preoperative lymphocyte-monocyte ratio (LMR) in patients with endometrial cancer (EC).Methods: We retrospectively examined LMR as a variable cohort 255 EC who underwent surgical resection.Patients were categorized into two groups according to (LMR-low and LMR-high) using cutoff points determined by receiving operator characteristic (ROC) curve analysis.The primary objective was correlate clinicopathological factors; secondary determine...
Objective: The aim of the present study was to determine prognostic significances markers preoperative systemic inflammatory response (SIR) in patients with ovarian clear cell carcinoma (OCCC). Methods: A total 109 diagnosed OCCC that underwent primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2009 2012 were enrolled this retrospective study. SIR calculated complete blood counts determined before surgery. Receiver operating characteristic (ROC) curve analysis used...
PD-L1 expression levels determined by immunostaining are known to be related the survival rate and prognosis of patients with various types cancers, as well therapeutic response immune checkpoint inhibitors. Recently, U.S. Food Drug Administration approved an inhibitor for treatment non-small cell lung cancer along clones used predict resulting response. In this study, we performed tissue microarrays from ovarian epithelial using SP263, clone, examined effect on prognosis.Tissue were...
Deoxynivalenol (DON), a prevalent mycotoxin produced by Fusarium species, contaminates global agricultural products and poses significant health risks, particularly to the gastrointestinal (GI) system. DON exposure disrupts ribosomal function, inducing stress responses linked various inflammatory diseases, including bowel disease (IBD). In this study, we elucidate novel regulatory mechanism involving proteins (RPs) RPL13A RPS3, which mediate proinflammatory chemokine production in...
Abstract BACKGROUND: Resistance to apoptosis is 1 of the key events that confer chemoresistance and mediated by overexpression antiapoptotic proteins, which inhibit caspase activation. The objective this study was evaluate whether activation an alternative, caspase‐independent cell death pathway could promote in chemoresistant ovarian cancer cells. authors report characterization NV‐128 as inducer through a pathway. METHODS: Primary cultures epithelial (EOC) cells were treated with...
Anticancer activity of silibinin, a flavonoid, has been demonstrated in various cancer cell types. However, the underlying mechanisms were not elucidated human ovarian cells. The present study was undertaken to examine effect silibinin vitro and vivo on tumor growth Silibinin decreased viability dose- time-dependent manner. caused an increase reactive oxygen species (ROS) generation, silibinin-induced death prevented by antioxidant N-acetylcysteine (NAC). Western blot analysis showed...
Objective: To evaluate the role of inflammatory markers for distinguishing malignant and benign ovarian masses. Methods: Preoperative demographic, clinicopathologic, laboratory variables were reviewed in patients with an mass that was subsequently diagnosed as either epithelial cancer (EOC) or a on histologic analysis. The differences between two groups further evaluated. Logistic regression analysis applied to predict presence EOC. Results: According 229 EOC, 120 (52.4%) had serous...
The therapeutic effect of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with epithelial ovarian cancer (EOC) somatic BRCA mutations is consistent that observed germline mutations, indicating the importance detecting both and concurrently. We compared efficacy multi-gene panel next generation sequencing (NGS) EOC patients' formalin-fixed, paraffin-embedded (FFPE) tissue to conventional Sanger blood samples.This study included 48 EOC, FFPE NGS were conducted all them. Clinical...
We investigated whether the level of vascular endothelial growth factor (VEGF), placental (PlGF), and soluble VEGF receptor-1 (sFlt-1) in midtrimester amniotic fluid preterm birth have different values compared with term delivery.Our participants were 86 pregnant women who had undergone amniocentesis from 16 to 19 weeks gestation. Forty-three cases delivery, other 43 matched full-term delivery. Stored was after The levels VEGF, PlGF, sFlt-1 measured by enzyme-linked immunosorbent assay...
Objective To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. Methods We retrospectively reviewed medical records 309 cancer who were currently receiving and undergoing regular gynecological examination. Results evaluated 92 pre- 217 postmenopausal women. The prevalence endometrial thickening was 12% 10.6% group. An biopsy performed 43 confirmed 1, polyps 14, hyperplasia 4 Transvaginal ultrasonography showed 25 cases newly developed ovarian cysts....
Tumor markers are useful for detection and preoperative evaluation of ovarian tumors. We evaluated the clinical usefulness cancer antigen (CA) 125, human epididymis 4 (HE4), CA72-4 levels Risk Ovarian Malignancy Algorithm (ROMA) values differential diagnosis malignant borderline tumors among suspected tumors, effects endometriosis on these tumor markers.In a total 266 patients (213, 14, 39 with benign, respectively), CA125, HE4, were measured, ROMA calculated. Medians each marker compared...
Ovarian cancer stem-like cells (CSCs) have been implicated in tumor recurrence, metastasis, and drug resistance. Accumulating evidence has demonstrated the antitumor effect of plasma-activated medium (PAM) various carcinomas, including ovarian cancer. Thus, PAM represents a novel onco-therapeutic strategy. However, its impact on CSCs is unclear. Here, we show that resistant to high-dose conventional chemotherapeutic agents used for treatment exhibited dose-dependent sensitivity PAM. In...