A5042243795- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Forensic and Genetic Research
- Genetic diversity and population structure
- Advanced Proteomics Techniques and Applications
- Cancer Cells and Metastasis
- Gene expression and cancer classification
- Caveolin-1 and cellular processes
- Forensic Anthropology and Bioarchaeology Studies
- Wnt/β-catenin signaling in development and cancer
- RNA regulation and disease
- Race, Genetics, and Society
- Insect symbiosis and bacterial influences
- Protist diversity and phylogeny
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Animal Diversity and Health Studies
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Malaria Research and Control
- Mosquito-borne diseases and control
- Microbial Community Ecology and Physiology
- Yersinia bacterium, plague, ectoparasites research
European Institute of Oncology
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
University of Pavia
2016-2018
Istituto di Biologia e Biotecnologia Agraria
2015
Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, closest early Neolithic farmers. To learn more about their ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of cluster into 89 haplogroups most likely arose situ. For each Sardinian-specific haplogroup (SSH), also identified upstream node phylogeny, which non-Sardinian radiate. This provided minimum maximum time estimates for presence SSH...
Recent and compelling archaeological evidence attests to human presence ∼14.5 ka at multiple sites in South America a very early exploitation of extreme high-altitude Andean environments. Considering that, according genetic evidence, entry into North from Beringia most likely occurred ∼16 ka, these archeological findings would imply an extremely rapid spread along the double continent. To shed light on this issue perspective, we first completely sequenced 217 novel modern mitogenomes Native...
In the last 40 years, Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile and recently emerged Zika fever. To acquire more information on ancestral source(s) of adventive populations overall diffusion process from its native range, we analyzed mitogenome variation 27...
Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by Andes Amazon rainforest. The interactions between these paths their impact on peopling remain unclear. Analysis genetic variation in Peruvian regions located south River might provide clues this issue. We analyzed mitochondrial DNA at different Andean locations >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate trans-Andean...
Background Genetic studies support the scenario that Bos taurus domestication occurred in Near East during Neolithic transition about 10 thousand years (ky) ago, with likely exception of a minor secondary event Italy. However, despite proven effectiveness whole mitochondrial genome data providing valuable information concerning origin taurine cattle, until now no population surveys have been carried out at level mitogenomes local breeds from or surrounding areas. Egypt is close geographic...
Abstract Rare mitochondrial lineages with relict distributions can sometimes be disproportionately informative about deep events in human prehistory. We have studied one such lineage, haplogroup R0a, which uniquely is most frequent Arabia and the Horn of Africa, but distributed much more widely, from Europe to India. conclude that: (1) lineage ancestral R0a ancient than previously thought, a distribution across Mediterranean/Southwest Asia; (2) has deeper presence highlighting role at least...
Increasing evidence linking epigenetic mechanisms and different diseases, including cancer, has prompted in the last 15 years investigation of histone post-translational modifications (PTMs) clinical samples. Methods allowing isolation histones from patient samples followed by accurate comprehensive quantification their PTMs mass spectrometry (MS) have been developed. However, applicability these methods is limited requirement for substantial amounts material. To address this issue, study we...
Abstract Genome integrity is continuously threatened by endogenous sources of DNA damage including reactive oxygen species (ROS) produced cell metabolism. Factors the RNA interference (RNAi) machinery have been recently involved in cellular response to (DDR) proliferating cells. To investigate impact component RNAi on DDR activation terminally differentiated cells, we exploited cytoplasmic hybrid (cybrid) lines which mitochondria sporadic Parkinson’s disease patients repopulate neuroblastoma...
Epigenetic aberrations have been recognized as important contributors to cancer onset and development, increasing evidence suggests that linker histone H1 variants may serve biomarkers useful for patient stratification, well play an role drivers in cancer. Although traditionally levels studied using antibody-based methods RNA expression, these approaches suffer from limitations. Mass spectrometry (MS)-based proteomics represents the ideal tool accurately quantify relative changes protein...
Abstract Intratumor morphological heterogeneity predicts clinical outcomes of pancreatic ductal adenocarcinoma (PDAC). However, it is only partially understood at the molecular level and devoid actionability. In this study we set out to determine gene regulatory networks expression programs underpinning intra-tumor variation in PDAC. To aim, identified deconvoluted single cell profiles characteristic morphologically distinguishable clusters PDAC cells that coexisted individual tumors. We...
WNT signaling is central to spatial tissue arrangement and regulating stem cell activity, it represents the hallmark of gastrointestinal cancers. Although its role in driving intestinal tumors well characterized, WNT's gastric tumorigenesis remains elusive.