A5037534511- Forensic and Genetic Research
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Forensic Anthropology and Bioarchaeology Studies
- Mitochondrial Function and Pathology
- Race, Genetics, and Society
- Metabolism and Genetic Disorders
- Yersinia bacterium, plague, ectoparasites research
- Archaeology and ancient environmental studies
- Molecular Biology Techniques and Applications
- Genomics and Rare Diseases
- Statistical Mechanics and Entropy
- Identification and Quantification in Food
- Paleopathology and ancient diseases
- Genetic and phenotypic traits in livestock
- Metabolomics and Mass Spectrometry Studies
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Pacific and Southeast Asian Studies
- Advanced Thermodynamics and Statistical Mechanics
- Scientific Research and Discoveries
- RNA modifications and cancer
- Colonialism, slavery, and trade
- Pleistocene-Era Hominins and Archaeology
- Solar and Space Plasma Dynamics
University of Glasgow
2007-2019
University of Huddersfield
2005
University of Pavia
2005
Sapienza University of Rome
2005
Hospital Kuala Lumpur
2005
University of Oxford
1995-2004
Wellcome Centre for Mitochondrial Research
2002
Emory University
2002
University of California, Irvine
2002
Cornell University
2002
Human mtDNA shows striking regional variation, traditionally attributed to genetic drift. However, it is not easy account for the fact that only two lineages (M and N) left Africa colonize Eurasia A, C, D, G show a 5-fold enrichment from central Asia Siberia. As an alternative drift, natural selection might have enriched certain as people migrated north into colder climates. To test this hypothesis we analyzed 104 complete sequences all global regions lineages. African variation did...
A recent dispersal of modern humans out Africa is now widely accepted, but the routes taken across Eurasia are still disputed. We show that mitochondrial DNA variation in isolated “relict” populations southeast Asia supports view there was only a single from Africa, most likely via southern coastal route, through India and onward into Australasia. There an early offshoot, leading ultimately to settlement Near East Europe, main Australia ∼65,000 years ago rapid, taking few thousand years.
For most of the past century, prehistorians have had to rely on fossil and archaeological records in order reconstruct past. In last few decades, this evidence has been substantially supplemented from classical human genetics. More recently, phylogenetic analyses DNA sequences that incorporate geographical information provided a high‐resolution tool for investigation prehistoric demographic events, such as founder effects population expansions. These events can be dated using molecular clock...
Although fossil remains show that anatomically modern humans dispersed out of Africa into the Near East ∼100 to 130 ka, genetic evidence from extant populations has suggested non-Africans descend primarily a single successful later migration. Within human mitochondrial DNA (mtDNA) tree, haplogroup L3 encompasses not only many sub-Saharan Africans but also all ancient non-African lineages, and its age therefore provides an upper bound for dispersal Africa. An analysis 369 complete African...
Modern humans have been living in Island Southeast Asia (ISEA) for at least 50,000 years.Largely because of the influence linguistic studies, however, which a shallow time depth, attention archaeologists and geneticists has usually focused on last 6,000 years-in particular, proposed Neolithic dispersal from China Taiwan.Here we use complete mitochondrial DNA (mtDNA) genome sequencing to spotlight some earlier processes that clearly had major role demographic history region but hitherto...
Summary We have analysed 302 bp of the first hypervariable region mitochondrial D‐loop in 271 individuals from different regions Iberian Peninsula and 85 Algeria. The Basque population is significantly neighbouring populations terms overall levels diversity. This because majority sequences Basques are restricted to lineage group defined by CRS (Cambridge Reference Sequence) its derivatives although, like other populations, they showed a unimodal distribution pairwise sequence differences....
Mitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as active marker tumorigenesis various types cancer. Here we question the conclusions drawn most these investigations, especially those published high-rank cancer research journals, under evidence that a significant medical mtDNA studies are based on obviously flawed sequencing results.In our analyses, take phylogenetic approach and employ thorough database searches,...
Studying the genetic history of Orang Asli Peninsular Malaysia can provide crucial clues to peopling Southeast Asia as a whole. We have analyzed mitochondrial DNA (mtDNAs) control-region and coding-region markers in 447 mtDNAs from region, including 260 Asli, representative each traditional groupings, Semang, Senoi, Aboriginal Malays, allowing us test hypotheses about their origins. All groups undergone high levels drift, but phylogeographic traces nevertheless remain ancestry maternal...