A5018005982- Linguistics and Cultural Studies
- Forensic and Genetic Research
- SARS-CoV-2 and COVID-19 Research
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Eurasian Exchange Networks
- COVID-19 Clinical Research Studies
- Yersinia bacterium, plague, ectoparasites research
- Respiratory viral infections research
- Animal Virus Infections Studies
- Trace Elements in Health
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Virology and Viral Diseases
- RNA and protein synthesis mechanisms
- Pleistocene-Era Hominins and Archaeology
- Evolution and Paleontology Studies
- SARS-CoV-2 detection and testing
- Nutrition, Genetics, and Disease
- Heavy Metal Exposure and Toxicity
- Public Policy and Administration Research
- RNA Research and Splicing
- COVID-19 epidemiological studies
- Prion Diseases and Protein Misfolding
- vaccines and immunoinformatics approaches
University of Tartu
2012-2024
Estonian Biocentre
2012-2019
As of June 2020, the number people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, more than 6.7 million cases worldwide. Both World Health Organization (WHO) and United Nations (UN) has highlighted need for better control SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies antiviral drugs against can be time-consuming costly. Convalescent sera safe-in-man broad-spectrum antivirals (BSAAs) are readily...
The genetic origins of Uralic speakers from across a vast territory in the temperate zone North Eurasia have remained elusive. Previous studies shown contrasting proportions Eastern and Western Eurasian ancestry their mitochondrial Y chromosomal gene pools. While maternal lineages reflect by large geographic background given Uralic-speaking population, frequency chromosomes origin is distinctively high among European speakers. autosomal variation speakers, however, has not yet been studied...
A Southwest Asian origin and dispersal to North Africa in the Early Upper Palaeolithic era has been inferred previous studies for mtDNA haplogroups M1 U6. Both have proposed show similar geographic patterns shared demographic histories. We report here 24 33 U6 new complete sequences that allow us refine existing phylogeny of these haplogroups. The resulting phylogenetic information was used genotype a further 131 91 samples determine spread their sub-clades. No southwest specific clades or...
Abstract Human Y chromosome haplogroup J1-M267 is a common male lineage in West Asia. One high-frequency region—encompassing the Arabian Peninsula, southern Mesopotamia, and Levant—resides ~ 2000 km away from other one found Caucasus. The region between them, although has lower frequency, nevertheless demonstrates high genetic diversity. Studies associate this with spread of farming Fertile Crescent to Europe, mobile pastoralism desert regions history Jews, Islam. Here, we study past human...
Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting Republic Belarus. together with Ukrainians Russians represent East Slavic linguistic group, largest both in numbers territory, Europe alongside Baltic-, Finno-Permic- Turkic-speaking people. Till date, only a limited number low resolution genetic studies have been performed on this population. Therefore, phylogeographic analysis 565 Y-chromosomes 267 mitochondrial DNAs from six well covered geographic...
Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups present-day populations of Europe. While most subclades are older than 30 thousand years, comparatively recent coalescence time extant variation U7 (~16–19 years ago) suggests its current distribution consequence more dispersal events, despite wide geographical range across...
Abstract As of June 2020, the number people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, more than 6,5 million cases worldwide. Both World Health Organization (WHO) and United Nations (UN) has highlighted need for better control SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies antiviral drugs against can be time-consuming costly. Convalescent sera safe-in-man broad-spectrum antivirals (BSAAs) are...
Abstract Population-based biobanks enable genomic screening to support initiatives that prevent disease onset or slow its progression and estimate the prevalence of genetic diseases in population. Wilson’s (WD) is a rare copper-accumulation disorder for which timely intervention crucial, as treatment readily available. We studied WD Estonian Biobank population advance patient screening, swift diagnosis, subsequent treatment. Combined analysis genotype phenotype data from electronic health...
Background The COVID-19 pandemic was characterised by rapid waves of disease, carried the emergence new and more infectious SARS-CoV-2 virus variants. How unfolded in various locations during its first two years has yet to be sufficiently covered. To this end, here we are looking at circulating variants, their diversity, hospitalisation rates Estonia period from March 2000 2022. Methods We sequenced a total 27,550 samples between 2020 High-quality sequences were genotyped assigned Nextstrain...
Abstract Population-based biobanks enable genomic screening to support initiatives that prevent disease onset or slow its progression and estimate the prevalence of genetic diseases in population. Wilson’s (WD) is a rare copper-accumulation disorder for which timely intervention crucial, as treatment readily available. We studied WD Estonian Biobank population advance patient screening, swift diagnosis, subsequent treatment. Combined analysis genotype phenotype data from electronic health...
Purpose We aimed to describe SARS-CoV-2 lineages and diversity in children adults Estonia similarity travel-related cases neighbouring countries. Methods sequences 2021–2022 from a nationwide study were included. The proportion of predominant Estonian regions among was described by multinomial logistic regression. Simpson’s indices compared using linear Dynamics Bray-Curtis dissimilarity applying fuzzy clustering non-metrical dimensional scaling results. Results A total 2,630 (<15 years)...
Abstract The Oirats are a group of Mongolian-speaking peoples residing in Russia, China, and Mongolia, who speak Oirat dialects the Mongolian language. Migrations nomadic ethnopolitical formations across Eurasian Steppe during Late Middle Ages/early Modern times resulted wide geographic spread ethnic groups from present-day northwestern China East Asia to Lower Volga region Eastern Europe. In this study, we generate new genome-wide mitochondrial DNA data for Oirat-speaking populations...
Despite the high number of SARS-CoV-2 infections, only a few cases dual infection have been reported. Here, we describe case COVID-19 caused simultaneously by Delta and Omicron variants in an immunocompetent individual during early emergence variant. A 73-year-old man was hospitalized with suspected acute coronary syndrome positive test result for RNA received routine testing at hospital. He experienced mild symptoms discharged on ninth day. We sequenced whole genome from sample obtained...
Educational field is impelled to increase performance and quality, financial discipline, strategic behaviour its goals in order enhance “effectiveness”. As a result the incorporation of private sector management practices into educational taking place. But it important notice that proliferation managerial goes along with conflict-laden contradictory process. Education provides an area implementation for techniques evaluation aimed at improving public services. One most common conceptual...