A5001382787- Forensic and Genetic Research
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Molecular Biology Techniques and Applications
- Identification and Quantification in Food
- SARS-CoV-2 and COVID-19 Research
- Yersinia bacterium, plague, ectoparasites research
- COVID-19 Clinical Research Studies
- Race, Genetics, and Society
- South Asian Studies and Conflicts
- COVID-19 epidemiological studies
- Demographic Trends and Gender Preferences
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- interferon and immune responses
- Archaeology and ancient environmental studies
- Pacific and Southeast Asian Studies
- Genetic and phenotypic traits in livestock
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Immune responses and vaccinations
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
Banaras Hindu University
2017-2025
Central Forensic Science Laboratory
2024
Estonian Biocentre
2011-2020
University of Tartu
2009-2020
Indian Institute of Technology BHU
2020
Centre for Cellular and Molecular Biology
2005-2017
Narendra Dev University of Agriculture and Technology
2004
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, date the Y-chromosomal most recent common ancestor (MRCA) Africa at 254 (95% CI 192–307) kya and detect cluster major founder haplogroups narrow time interval 47–52 kya,...
Because of the ongoing pandemic around world, mechanisms underlying SARS-CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for SARS-CoV-1 virus, we suggest how CoV-2 localization RNA transcripts in mitochondria hijacks host cell’s mitochondrial function viral advantage. Besides transcripts, also localizes mitochondria. SARS-CoV-2 may manipulate indirectly, first by ACE2 regulation function, and once it enters cell, open-reading frames (ORFs) such as ORF-9b...
The origin of the Andaman "Negrito" and Nicobar "Mongoloid" populations has been ambiguous. Our analyses complete mitochondrial DNA sequences from Onges Great revealed two deeply branching clades that share their most recent common ancestor in founder haplogroup M, with lineages spread among India, Africa, East Asia, New Guinea, Australia. This distribution suggests these have likely survived genetic isolation since initial settlement islands during an out-of-Africa migration by anatomically...
The geographic origin and time of dispersal Austroasiatic (AA) speakers, presently settled in south southeast Asia, remains disputed. Two rival hypotheses, both assuming a demic component to the language dispersal, have been proposed. first these places speakers Asia with later during Neolithic, whereas second hypothesis advocates pre-Neolithic origins this family from Asia. To test two alternative models, study combines analysis uniparentally inherited markers 610,000 common single...
Genetic studies of South Asia's population history have led to postulations a significant and early expansion in the subcontinent, dating sometime Late Pleistocene. We evaluate this argument, based on new mtDNA analyses, find evidence for demographic transition 35-28 ka. then examine paleoenvironmental and, particularly, archaeological records time period note that putative event coincides with ecological technological change Asia. document development diminutive stone blade (microlithic)...
Skin pigmentation is one of the most variable phenotypic traits in humans. A non-synonymous substitution (rs1426654) third exon SLC24A5 accounts for lighter skin Europeans but not East Asians. previous genome-wide association study carried out a heterogeneous sample UK immigrants South Asian descent suggested that this gene also contributes significantly to variation among In present study, we have quantitatively assessed largely homogeneous cohort 1228 individuals from Southern region...
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies shown striking difference of allele frequency among Europeans and Asians polymorphism rs2285666, present in <italic>ACE2</italic>. It has been revealed that the alternate (TT-plus strand or AA-minus strand) rs2285666 elevate expression level this gene upto 50%, hence may play significant role SARS-CoV-2 susceptibility....
Milk consumption and lactose digestion after weaning are exclusively human traits made possible by the continued production of enzyme lactase in adulthood. Multiple independent mutations a 100-bp region—part an enhancer—approximately 14-kb upstream LCT gene associated with this trait Europeans pastoralists from Saudi Arabia Africa. However, single mutation purported western Eurasian origin accounts for much observed persistence outside Given high levels present-day milk India, together...
Abstract Background Macrohaplogroups 'M' and 'N' have evolved almost in parallel from a founder haplogroup L3. Macrohaplogroup N India has already been defined previous studies recently the macrohaplogroup M among Indian populations characterized. In this study, we attempted to reconstruct re-evaluate phylogeny of M, which harbors more than 60% mtDNA lineage, shed light on origin its deep rooting haplogroups. Results Using 11 whole 2231 partial coding sequence lineage selected 8670 HVS1...
Abstract Background India is a country with enormous social and cultural diversity due to its positioning on the crossroads of many historic pre-historic human migrations. The hierarchical caste system in Hindu society dominates structure Indian populations. origin matter debate linguists anthropologists suggesting that it began arrival Indo-European speakers from Central Asia about 3500 years ago. Previous genetic studies based populations failed achieve consensus this regard. We analysed...
Abstract In recent years, mtDNA and Y chromosome studies involving human populations from South Asia the rest of world have revealed new insights about peopling by anatomically modern humans during late Pleistocene, some 40,000–60,000 years ago, over southern coastal route Africa. Molecular archaeological record are both largely consistent with autochthonous differentiation genetic structure caste tribal in Asia. High level endogamy created numerous social boundaries within between castes...
Abstract Surrounded by speakers of Indo-European, Dravidian and Tibeto-Burman languages, around 11 million Munda (a branch Austroasiatic language family) live in the densely populated genetically diverse South Asia. Their genetic makeup holds components characteristic Asians as well Southeast Asians. The admixture time between these has been previously estimated on basis archaeology, linguistics uniparental markers. Using genome-wide genotype data 102 contextual from Asia, we retrieved dates...
SARS-CoV-2, the causative agent for COVID-19, an ongoing pandemic, engages ACE2 receptor to enter host cell through S protein priming by a serine protease, TMPRSS2. Variation in TMPRSS2 gene may account disparity disease susceptibility between populations. Therefore, present study, we have used next-generation sequencing (NGS) data of world populations from 393 individuals and analyzed using haplotype-based approach with major focus on South Asia study its phylogenetic structure their...
Abstract The domestication of animals is a major milestone in human history and has been studied various fields. Pig domestication, particular, widely studied, it believed that India one at least six centers. However, there lack systematic studies using high-resolution genetic markers, including complete mitogenomes, to investigate the roots pigs India. In present study, we investigated origin evolution Indian mitochondrial data complement archaeological datasets. phylogenetic status pig...