A5028113075- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Forensic Anthropology and Bioarchaeology Studies
- RNA Research and Splicing
- Forensic and Genetic Research
- Autopsy Techniques and Outcomes
- Diabetes and associated disorders
- COVID-19 epidemiological studies
- RNA modifications and cancer
- Agricultural Economics and Practices
- Animal Virus Infections Studies
- Spine and Intervertebral Disc Pathology
- Genomics and Chromatin Dynamics
- Insurance, Mortality, Demography, Risk Management
- Virology and Viral Diseases
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Pregnancy-related medical research
- Cerebral Venous Sinus Thrombosis
- Estrogen and related hormone effects
- Hedgehog Signaling Pathway Studies
- Global Health Workforce Issues
- DNA Repair Mechanisms
- demographic modeling and climate adaptation
Banaras Hindu University
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023
National and Kapodistrian University of Athens
2023
All India Institute of Medical Sciences
2023
Indian Institute of Technology Delhi
2023
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2023
All India Institute of Medical Sciences Rishikesh
2022
Inserm
2020-2021
Institut de Biologie de l'École Normale Supérieure
2016-2021
Université Paris Sciences et Lettres
2020-2021
Abstract Exon junction complexes (EJCs) mark untranslated spliced mRNAs and are crucial for the mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) division is linked to human neurodevelopmental disorders. In quiescent mNSC immortalized retinal pigment epithelial (RPE1) cells, centrioles form a basal body ciliogenesis. Here, we report that EJCs accumulate at bodies of or RPE1 cells decline when these differentiate resume growth. A high-throughput smFISH screen...
Abstract The domestication of animals is a major milestone in human history and has been studied various fields. Pig domestication, particular, widely studied, it believed that India one at least six centers. However, there lack systematic studies using high-resolution genetic markers, including complete mitogenomes, to investigate the roots pigs India. In present study, we investigated origin evolution Indian mitochondrial data complement archaeological datasets. phylogenetic status pig...
Stimuli‐responsive materials can frequently tune between their temporary and original shapes, have the potential for artificial intelligence‐based technologies in robotics, aerospace, biomedical, engineering, security, etc. Shape memory polymers (SMPs) are promising these but inadequate thermal electrical characteristics causing slow shape recovery limit practical applications. Herein, first time, comprehensively precisely polyurethane (PU), a SMP, via variety of novel layered titanium...
When the number of lumbar and sacral vertebrae is being assessed, variations from typical lumbosacral anatomy may confuse practitioner, potentially leading to significant clinical errors. In this study, authors describe statistical variation in spine an outpatient imaging setting, evaluate potential implications for practice based on lumbar-type identified, recommend a method rapidly determining vertebral bodies (VBs) outpatients referred MR imaging.A total 762 patients (male female) who...
Abstract SARS CoV-2, the causative agent for ongoing COVID-19 pandemic, it enters host cell by activating ACE2 receptor with help of two proteasesi.e., Furin and TMPRSS2. Therefore, variations in these genes may account differential susceptibility severity between populations. Previous studies have shown that role TMPRSS2 gene variants understanding among Indian Nevertheless, a knowledge gap exists concerning diverse South Asian ethnic groups. Investigating their global phylogeographic...
Background Dydrogesterone, an oral selective progesterone receptor agonist with high bioavailability, has been used since the 1960s to treat various conditions arising due deficiency of progesterone. Patients are expected have additional compliance and reduced pill burden dydrogesterone 20 mg 30 SR once a day (OD) for requiring 10 twice (BID) or thrice (TID). Methodology A real-world analysis was conducted using HealthPlix electronic medical records (EMR) database understand demography,...
Abstract Introduction: Adverse reactions to radiopaque contrast media (RCM) are well documented with a wide range of incidences reported. The objective this study was determine how many patients in sample 200 who presents for interventional pain treatments report history adverse RCM. Methods: Data from outpatients were collected using self‐administered questionnaire. questionnaire designed obtain information about prior exposure RCM and any events plus other general allergic including known...
The ongoing COVID-19 pandemic has been a scientific, medical and social challenge. Since clinical course of this disease is largely unpredictable can develop rapidly causing severe complications, it important to identify laboratory biomarkers, which may help classify patient’s severity during initial stage. Previous studies have suggested C—reactive protein (inflammatory) D-dimer (biochemical) as an effective biomarker. differential in patients across the world our limited understanding...
After the spill to humans, in evolutionary timeline of SARS-CoV-2, several positively selected variants have emerged. A phylogeographic study on these can reveal their spatial and temporal distribution. In December 2020, alpha variant severe acute respiratory syndrome coronavirus (SARS-CoV-2), which has been designated as a concern (VOC) by WHO, was discovered south-eastern United Kingdom (UK). Slowly, it expanded across India, with considerable number cases, particularly North India. This...
Abstract Background Replication and transcription, the two key functions of DNA, require unwinding DNA double helix. It has been shown that replication origins in budding yeast, Saccharomyces cerevisiae contain an easily unwound stretch DNA. We have used a recently developed method for determining locations degrees stress-induced duplex destabilization (SIDD) all reported genome fission Schizosaccharomyces pombe . Results found are more susceptible to SIDD as compared non-origin intergenic...
Abstract Background SARS CoV-2, the causative agent for ongoing COVID-19 pandemic, enters host cell by activating ACE2 receptor with help of two proteases, i.e., Furin and TMPRSS2. Therefore, variations in these genes may account differential susceptibility severity between populations. Our previous studies have shown that TMPRSS2 gene variants are essential understanding among Indian However, there is a knowledge gap regarding their phylogenetic structure diverse South Asian ethnic groups...
Abstract Exon junction complexes (EJC) mark untranslated spliced mRNAs and are crucial for the mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) division is linked to human neurodevelopmental disorders. In quiescent mNSC immortalized retinal pigment epithelial (RPE1) cells, centrioles form a basal body ciliogenesis. Here, we report that EJCs accumulate at bodies of or RPE1 cells decline when these differentiate resume growth. A high-throughput smFISH screen...
Abstract The COVID-19 pandemic has resulted several waves of infection in many countries worldwide. large variations case fatality ratio among different geographical regions suggests that the human susceptibility against this virus varies substantially. Several studies from parts world showed a significant association ABO blood group and susceptibility. It was shown individuals with O are at lower risk coronavirus infection. To establish SARS-CoV-2 susceptibility, we for first time analysed...
Synoptic AbstractThe article considers various parametric models proposed for studying age-specific fertility patterns and develops a Bayesian alternative their analyses. The analysis is done using weak proper priors the parameters. Since posterior involves analytically intractable integrals, uses Metropolis algorithm to draw corresponding samples hence obtains sample based inferences. maximum likelihood estimates of parameters are also obtained by non-linear optimization technique. Such...
A 42-year-old man presented with a history of recurrent loose motions for the previous 7 months. The patient also had diabetes mellitus last 10 years and was uncontrolled on oral hypoglycaemic agents but responded to insulin. There no any addiction. Examination investigations showed presence malabsorption along calcified pancreas. thrombus noted in inferior vena cava. In absence alcohol intake, diagnosis fibrocalcific pancreatic made investigated other hypercoagulable states none found. put...
With the rollout of world's largest vaccine drive for SARS-CoV-2 by Government India on January 16 2021, had targeted to vaccinate its entire population end 2021. Struggling with procurement and production earlier, overcome these hurdles, but Indian still did not seem be mobilizing swiftly toward vaccination centers. The severe second wave has slowed pace was also one major contributing factors hesitancy. To understand nature hesitancy underlying factors, we conducted extensive online...