A5035668030- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Forensic and Genetic Research
- Genetic diversity and population structure
- South Asian Studies and Conflicts
- COVID-19 epidemiological studies
- Forensic Anthropology and Bioarchaeology Studies
- Animal Virus Infections Studies
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Virology and Viral Diseases
- Erythrocyte Function and Pathophysiology
- Yersinia bacterium, plague, ectoparasites research
- Blood groups and transfusion
- Diabetes and associated disorders
- Identification and Quantification in Food
- Telomeres, Telomerase, and Senescence
- Animal Disease Management and Epidemiology
- Southeast Asian Sociopolitical Studies
- Rangeland Management and Livestock Ecology
- Swearing, Euphemism, Multilingualism
- Cancer-related molecular mechanisms research
Banaras Hindu University
2019-2025
University of Tartu
2019
Estonian Biocentre
2019
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies shown striking difference of allele frequency among Europeans and Asians polymorphism rs2285666, present in <italic>ACE2</italic>. It has been revealed that the alternate (TT-plus strand or AA-minus strand) rs2285666 elevate expression level this gene upto 50%, hence may play significant role SARS-CoV-2 susceptibility....
SARS-CoV-2, the causative agent for COVID-19, an ongoing pandemic, engages ACE2 receptor to enter host cell through S protein priming by a serine protease, TMPRSS2. Variation in TMPRSS2 gene may account disparity disease susceptibility between populations. Therefore, present study, we have used next-generation sequencing (NGS) data of world populations from 393 individuals and analyzed using haplotype-based approach with major focus on South Asia study its phylogenetic structure their...
It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect susceptibility a population. Therefore, we have analysed sequence data ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, Asians are more related to West Eurasian populations rather than East Eurasians. In present analyses ACE2, observed majority Asian haplotypes closer Eurasians The phylogenetic analysis suggested shared...
Abstract The domestication of animals is a major milestone in human history and has been studied various fields. Pig domestication, particular, widely studied, it believed that India one at least six centers. However, there lack systematic studies using high-resolution genetic markers, including complete mitogenomes, to investigate the roots pigs India. In present study, we investigated origin evolution Indian mitochondrial data complement archaeological datasets. phylogenetic status pig...
Abstract With the growing evidence on variable human susceptibility against COVID-19, it is evident that some genetic loci modulate severity of infection. Recent studies have identified several associated with greater severity. More recently, a study has 50 kb genomic segment introgressed from Neanderthal adding risk for and this present among 16% 50% people European South Asian descent, respectively. Our ACE2 haplotype 20% 60% populations, respectively, which appears to be responsible low...
Abstract SARS CoV-2, the causative agent for ongoing COVID-19 pandemic, it enters host cell by activating ACE2 receptor with help of two proteasesi.e., Furin and TMPRSS2. Therefore, variations in these genes may account differential susceptibility severity between populations. Previous studies have shown that role TMPRSS2 gene variants understanding among Indian Nevertheless, a knowledge gap exists concerning diverse South Asian ethnic groups. Investigating their global phylogeographic...
In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across the world within a few months. The SARS-CoV-2 pandemic has had devastating effect on humanity, with social and economic consequences. continents of Europe America have been hit hardest. However, there also huge loss life in India, country having fourth highest number total deaths worldwide. Nevertheless, infection death rates per million case fatality ratio India are substantially lower than those many...
The Sinhalese are the major ethnic group in Śrī Laṅkā, inhabiting nearly whole length and breadth of island. They speak an Indo-European language Indo-Iranian branch, which is held to originate northwestern India, going back at least fifth century BC. Previous genetic studies on low-resolution markers failed infer genomic history population. Therefore, we have performed a high-resolution fine-grained study population and, broader context, attempted reconstruct Laṅkā. Our...
Abstract Infection born by Coronavirus SARS-CoV-2 has swept the world within a time of few months. It created devastating effect on humanity with social and economic depressions. Europe America were hardest hit continents. India also lost several lives, making country fourth most deadly worldwide. However, infection death rate per million case fatality ratio in substantially lower than many developed nations. Several factors have been proposed including genetics. One important facts is that...
Abstract The archipelago of Lakshadweep is considered as a stopover to the maritime route since ancient time. It not very clear when human first occupied these islands, however in long history local legends suggest that has been ruled by different kingdoms. To have better understanding peopling Lakshadweep, we analysed 557 individuals from eight major islands for mitochondrial DNA and 166 Y chromosome markers. We found strong founder effect both paternal maternal lineages. Moreover, report...
After the spill to humans, in evolutionary timeline of SARS-CoV-2, several positively selected variants have emerged. A phylogeographic study on these can reveal their spatial and temporal distribution. In December 2020, alpha variant severe acute respiratory syndrome coronavirus (SARS-CoV-2), which has been designated as a concern (VOC) by WHO, was discovered south-eastern United Kingdom (UK). Slowly, it expanded across India, with considerable number cases, particularly North India. This...
The ongoing COVID-19 pandemic has been a scientific, medical and social challenge. Since clinical course of this disease is largely unpredictable can develop rapidly causing severe complications, it important to identify laboratory biomarkers, which may help classify patient’s severity during initial stage. Previous studies have suggested C—reactive protein (inflammatory) D-dimer (biochemical) as an effective biomarker. differential in patients across the world our limited understanding...
The genetic landscape of South Asia is intriguing. In a vast geographical region like India, mostly genes follow geography, whereas in smaller e.g., Nepal, the more akin to languages. Moreover, neighboring regions East and Southeast Asia, language major denominator genes. However, these are not just two alternatives, many pockets, ethnicity plays stronger role than either these. Being crossroads Himalayan populated by people speaking Trans-Himalayan language. Archaeological anthropological...
The Northeastern region of India is considered a gateway for modern humans' dispersal throughout Asia. This mixture various ethnic and indigenous populations amalgamating multiple ancestries. One reason such amalgamation that, South Asia experienced historic migrations from parts the world. A few examples explored genetically are Jews, Parsis Siddis. Ahom dynasty that historically migrated to during 12th century. However, this putative migration has not been studied at high resolution....
Abstract Background SARS CoV-2, the causative agent for ongoing COVID-19 pandemic, enters host cell by activating ACE2 receptor with help of two proteases, i.e., Furin and TMPRSS2. Therefore, variations in these genes may account differential susceptibility severity between populations. Our previous studies have shown that TMPRSS2 gene variants are essential understanding among Indian However, there is a knowledge gap regarding their phylogenetic structure diverse South Asian ethnic groups...