A5049530504- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- HIV Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Hedgehog Signaling Pathway Studies
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Extracellular vesicles in disease
- Gut microbiota and health
- Advanced Breast Cancer Therapies
- Bacterial Genetics and Biotechnology
- Cancer-related Molecular Pathways
- Advances in Cucurbitaceae Research
- T-cell and B-cell Immunology
University of Oklahoma Health Sciences Center
2022-2025
The University of Texas Rio Grande Valley
2019-2024
Translational Health Science and Technology Institute
2019-2024
Maharishi Markandeshwar University, Mullana
2023
Center for Discovery
2023
Hackensack Meridian Health
2023
Rutgers, The State University of New Jersey
2022
University of Tennessee Health Science Center
2014-2022
Thermo Fisher Scientific (United States)
2022
Dean McGee Eye Institute
2022
Abstract Cervical cancer is one of the most common cancers among women worldwide. Current standards care for cervical includes surgery, radiation and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be highly viable option. Curcumin (CUR) well-known compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic...
Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which smaller intracellular membrane nanoparticle vesicles. have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, disseminating long-distance intercellular communications in various biological processes. Among cell-line or fluid derived exosomes, milk exosomes abundant nature exhibit many nanocarrier characteristics favorable theranostic applications. To an...
Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has showed potent anticancer and cancer prevention activity in variety cancers. However, clinical translation CUR been significantly hampered due to its extensive degradation, suboptimal pharmacokinetics, poor bioavailability. To address these clinically relevant issues, we have developed novel CUR-loaded magnetic nanoparticle (MNP-CUR) formulation. Herein, evaluated vitro vivo therapeutic efficacy this...
// Sheema Khan 1 , Mara C. Ebeling 2 Mohd S. Zaman Mohammed Sikander Murali M. Yallapu Neeraj Chauhan Ashley Yacoubian 3 Stephen W. Behrman 4 Nadeem Zafar Deepak Kumar 5 Paul A. Thompson 2,6 Meena Jaggi and Subhash Department of Pharmaceutical Sciences Center for Cancer Research, University Tennessee Health Science Center, Memphis, Tennessee, USA Biology Research Sanford Research/USD, Sioux Falls, South Dakota, Pathology, Surgery, Biological Environmental Sciences, the District Columbia,...
Background Multidrug resistant Klebsiella pneumoniae have caused major therapeutic problems worldwide due to the emergence of extended-spectrum β-lactamase producing strains. Although there are >10 facilitator super family (MFS) efflux pumps annotated in genome sequence K. bacillus, apparently less is known about their physiological relevance. Principal Findings Insertional inactivation kpnGH resulting increased susceptibility antibiotics such as azithromycin, ceftazidime, ciprofloxacin,...
The management of pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to lack an efficient therapy and development chemoresistance the current standard therapy, gemcitabine. Recent studies implicate intimate reciprocal interactions between epithelia underlying stroma paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia PDAC. Herein, we report for first time that a nonsteroidal drug, ormeloxifene, has potent anticancer properties depletes tumor-associated stromal tissue...
Abstract Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore. Herein, we report therapeutic effects of ormeloxifene on prostate cancer and elucidate novel molecular mechanism its activity. treatment inhibited epithelial-to-mesenchymal transition (EMT) process as evident by repression N-cadherin, Slug, Snail, vimentin, MMPs (MMP2 MMP3), β-catenin/TCF-4 transcriptional...
Indocyanine green (ICG) is one of the FDA-approved near infra-red fluorescent (NIRF) probes for cancer imaging and image-guided surgery in clinical setting. However, limitations ICG include poor photostability, high concentration toxicity, short circulation time, cell specificity. To overcome these hurdles, we engineered a nanoconstruct composed poly (vinyl pyrrolidone) (PVP)-indocyanine that cloaked self-assembled with tannic acid (termed as indocyanine green-based glow nanoparticles probe,...
Anorexia is a major cause of cancer cachexia and induced by growth differentiation factor-15 (GDF15), which activates the rearranged during transfection (RET) protein tyrosine kinase in hindbrain through GDF family receptor α-like (GFRAL), raising possibility targeting RET for treatment. RET-altered patients treated with RET-selective inhibitors gain weight, however, it unclear whether this results from tumor regression that improves overall health patients. Thus, potential using inhibitor...
Abstract Background Timely access to antiretroviral therapy is a key controlling HIV infection. Late diagnosis and presentation care diminish the benefits of antiretrovirals increase risk transmission. We aimed identify late presenters in patients sent for first CD4 T cell count after diagnosis, initiation evaluation. Further we at identifying patient factors associated with higher presentation. Methods Retrospective data collection analysis was done 3680 subjects visiting laboratory counts...
The management of pancreatic cancer (PanCa) is exceptionally difficult due to poor response available therapeutic modalities. Tubulins play a major role in cell dynamics, thus are important molecular targets for therapy. Among various tubulins, βIII and βIV-tubulin isoforms have been primarily implicated PanCa progression, metastasis chemo-resistance. However, specific inhibitors these that potent anti-cancer activity with low toxicity not readily available. We determined mechanisms efficacy...
Abstract The genome of Mycobacterium tuberculosis encodes for a large repertoire toxin-antitoxin systems. In the present study, MenT3 and MenT4 toxins belonging to MenAT subfamily TA systems have been functionally characterized. We demonstrate that ectopic expression these inhibits bacterial growth this is rescued upon co-expression their cognate antitoxins. Here, we show simultaneous deletion menT3 menT4 results in enhanced susceptibility M. exposure oxidative stress attenuated guinea pigs...
Klebsiella pneumoniae is a Gram-negative bacillus that causes serious infections in immunocompromised human hosts and exhibits significant multidrug resistance. In this study, we identified novel lysR-family regulator (designated oxyR(KP)) the genome of K. NTUH-K2044 whose functions have remained enigmatic so far. Functional characterization putative lysR oxyR(KP) with respect to cellular physiology antimicrobial susceptibility was performed by generating an isogenic mutant, ΔoxyR(KP)...
Abstract The “Landscape Of Gut Microbiome - Pan-India Exploration”, or LogMPIE study, is the first large-scale, nationwide record of Indian gut microbiome. primary objective study was to identify and map microbiome baseline. This observational conducted across 14 geographical locations in India. Enrolled subjects were uniformly distributed geographies (north, east, west south) body mass index (obese non-obese). Furthermore, factors influencing microbiome, such as age physical activity, also...
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered metabolic machinery in can be useful agent repression metastasis. Herein, we report cucurbitacin D (Cuc D) effectively inhibits uptake lactate production metastatic via modulating This shift by Cuc was correlated with decreased expression GLUT1 its direct binding as suggested proficient...