A5024010152- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- IPv6, Mobility, Handover, Networks, Security
- Nanoparticle-Based Drug Delivery
- Tuberculosis Research and Epidemiology
- MicroRNA in disease regulation
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Estrogen and related hormone effects
- Glycosylation and Glycoproteins Research
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Mycobacterium research and diagnosis
- Cancer, Lipids, and Metabolism
- Parallel Computing and Optimization Techniques
- Cervical Cancer and HPV Research
- ATP Synthase and ATPases Research
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- Interconnection Networks and Systems
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
The University of Texas Rio Grande Valley
2019-2025
University of Tennessee Health Science Center
2016-2024
Krishi Vigyan Kendra, Ghatkhed Amravati
2024
Center for Cancer Research
2018-2020
Rajendra Institute of Medical Sciences
2018-2020
Cancer Research Center
2018
Central Drug Research Institute
2012-2015
IBM (United States)
2003-2004
Endoplasmic reticulum (ER) stress is an intriguing target with significant clinical importance in chemotherapy. Interference ER functions can lead to the accumulation of unfolded proteins, as detected by transmembrane sensors that instigate protein response (UPR). Therefore, controlling induced UPR via natural compounds could be a novel therapeutic strategy for management prostate cancer. Tannic acid (a naturally occurring polyphenol) was used examine mediated pathway cancer cells. treatment...
Abstract Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act fuel for PCa proliferation. However, few studies were available that addressed topic of targeting in PCa. Here, we assessed tannic acid (TA) lipid-targeting ability its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) cells. TA exhibited dual effects inhibiting lipogenic suppression metabolic...
Abstract Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore. Herein, we report therapeutic effects of ormeloxifene on prostate cancer and elucidate novel molecular mechanism its activity. treatment inhibited epithelial-to-mesenchymal transition (EMT) process as evident by repression N-cadherin, Slug, Snail, vimentin, MMPs (MMP2 MMP3), β-catenin/TCF-4 transcriptional...
The therapeutic application of microRNA(s) in the field cancer has generated significant attention research. Previous studies have shown that miR-205 negatively regulates prostate cell proliferation, metastasis, and drug resistance. However, delivery is an unmet clinical need. Thus, development a viable nanoparticle platform to deliver highly sought. A novel magnetic (MNP)-based nanoplatform composed iron oxide core with poly(ethyleneimine)-poly(ethylene glycol) layer(s) was developed. An...
Insect pests pose a significant threat to agricultural production, requiring effective monitoring and management strategies. Recent advancements in remote sensing automated technologies offer promising solutions for early detection surveillance of insect systems. This review paper explores the current state-of-the-art approaches pest detection, including satellite imagery, unmanned aerial vehicles (UAVs), wireless sensor networks, machine learning algorithms. We discuss advantages,...
This study examines gender disparities in agricultural work participation across West Bengal from the 1960s to 2011, revealing consistently higher male engagement with significant regional variations. Districts such as Purulia, Hooghly, Bardhaman, and Bankura recorded female participation, whereas urbanized areas like Howrah, Nadia, 24-Parganas showed lower involvement. The Work Participation Rate (WPR) agriculture peaked 1980s but declined thereafter, reflecting economic diversification a...
Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, known to induce cellular which limits overall survival patients. Strategic therapies counter are unmet clinical need. Towards this effort was made a novel therapeutic strategy targets removes senescent cells from tumors, we...
Pancreatic tumors are rewired for high-glucose metabolism and typically present with exceptionally poor prognosis. Recently, we have shown that MUC13, which is highly expressed in pancreatic tumors, promotes tumor progression via modulation of HER2 receptor tyrosine kinase activity. Herein, investigate a novel, MUC13-mediated molecular mechanism responsible higher glucose tumors. Our results demonstrate MUC13 expression leads to the activation/nuclear translocation NF-κB p65 phosphorylation...
The management of pancreatic cancer (PanCa) is exceptionally difficult due to poor response available therapeutic modalities. Tubulins play a major role in cell dynamics, thus are important molecular targets for therapy. Among various tubulins, βIII and βIV-tubulin isoforms have been primarily implicated PanCa progression, metastasis chemo-resistance. However, specific inhibitors these that potent anti-cancer activity with low toxicity not readily available. We determined mechanisms efficacy...
ObjectivesMycobacterium fortuitum causes opportunist non-tubercular infection in humans. Chronic of M. has been clinically documented and requires prolonged chemotherapy. The objectives this study were to characterize acute persistent a murine model screen thiophene-containing trisubstituted methanes active against both infection.
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered metabolic machinery in can be useful agent repression metastasis. Herein, we report cucurbitacin D (Cuc D) effectively inhibits uptake lactate production metastatic via modulating This shift by Cuc was correlated with decreased expression GLUT1 its direct binding as suggested proficient...