A5005661533- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Telomeres, Telomerase, and Senescence
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inflammatory mediators and NSAID effects
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Graphene and Nanomaterials Applications
- Groundwater and Watershed Analysis
- Protein purification and stability
- Pharmaceutical studies and practices
- Statistical Methods in Clinical Trials
- Inhalation and Respiratory Drug Delivery
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Probiotics and Fermented Foods
- Biochemical and Molecular Research
- Synthesis and biological activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
University of Tennessee Health Science Center
2018-2024
Sardar Vallabhbhai National Institute of Technology Surat
2022
Takeda (United States)
2017
Millennium Engineering and Integration (United States)
2017
Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, known to induce cellular which limits overall survival patients. Strategic therapies counter are unmet clinical need. Towards this effort was made a novel therapeutic strategy targets removes senescent cells from tumors, we...
The lengthy treatment time for tuberculosis (TB) is a primary cause the emergence of multidrug resistant (MDR-TB). One approach to improve TB therapy develop an inhalational that when administered in combination with oral drugs eases and shortens treatment. Spectinamides are new semisynthetic analogues spectinomycin excellent activity against Mycobacterium (Mtb), including MDR XDR Mtb strains. Spectinamide-1599 was chosen as promising candidate development therapy. Using murine model...
Despite decades of research, tuberculosis remains a leading cause death from single infectious agent. Spectinamides are promising novel class antituberculosis agents, and the lead spectinamide 1810 has demonstrated excellent efficacy, safety, drug-like properties in numerous vitro vivo assessments mouse models tuberculosis. In current dose ranging fractionation study, we used 29 different combinations level dosing frequency to characterize exposure-response relationship for model...
Certain aromatic nitriles are well-known inhibitors of cysteine proteases. The mode action these compounds involves the formation a reversible or irreversible covalent bond between nitrile and thiol group in active site enzyme. However, reactivity nitrile-substituted heterocycles may lead inadvertently to nonspecific interactions with DNA, protein, glutathione, other endogenous components, resulting toxicity complicating use as therapeutic agents. In present study, intrinsic associated...
Spectinamides are a novel class of narrow-spectrum antitubercular agents with the potential to treat drug-resistant tuberculosis infections. Spectinamide 1810 has shown good safety record following subcutaneous injection in mice or infusion rats but exhibits transient acute toxicity bolus administration either species. To improve therapeutic index 1810, an injectable prodrug strategy was explored. The phosphate 3408 superior maximum tolerated dose compared Gentamicin. Following intravenous...
Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) extensively drug-resistant (XDR) tuberculosis. These have previously been tested at various combinations of dose level, dosing frequency, route administration in mouse models Mycobacterium tuberculosis (Mtb) infection healthy animals. Physiologically based pharmacokinetic (PBPK) modeling allows the prediction pharmacokinetics candidate drugs organs/tissues...
Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown mask the taste. Because potential benefit this for children, pilot study using porcine model conducted evaluate its relative bioavailability.
Abstract This study prioritized sub-watersheds in the Upper Bhima Basin based on their need for proper water resource planning and management. Morphometric analysis is essential determining soil erosion-prone areas. Some uncertainty was observed with morphometric variables of watersheds previous prioritization methods. A geographic information system (GIS) tool used to identify critical area. Weighted Sum Approach (WSA) technique developed rank each sub-watershed weightages derived from...