A5084952975- Inhalation and Respiratory Drug Delivery
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Pluripotent Stem Cells Research
- Various Chemistry Research Topics
- Zoonotic diseases and public health
- Animal Disease Management and Epidemiology
- Chemistry and Stereochemistry Studies
- Mosquito-borne diseases and control
- History and advancements in chemistry
- Cancer therapeutics and mechanisms
Colorado State University
2018-2021
University of Saint Joseph
2006
Hartford Financial Services (United States)
2006
Abstract Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log 10 CFU after two weeks treatment via aerosol delivery ST3-H2A2, [a selective peptide inhibitor the STAT3 N-terminal domain] or IL10R1-7 [selective for IL-10Ra] respectively when compared to control treated IL10R1-14...
The lengthy treatment time for tuberculosis (TB) is a primary cause the emergence of multidrug resistant (MDR-TB). One approach to improve TB therapy develop an inhalational that when administered in combination with oral drugs eases and shortens treatment. Spectinamides are new semisynthetic analogues spectinomycin excellent activity against Mycobacterium (Mtb), including MDR XDR Mtb strains. Spectinamide-1599 was chosen as promising candidate development therapy. Using murine model...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTA Mnemonic for Representative Element GroupsJennifer Arab and Timothy Chambers View Author InformationSaint Joseph College, West Hartford, CT 06117Department of Philosophy, University 06117Cite this: J. Chem. Educ. 2006, 83, 12, 1761Publication Date (Web):December 1, 2006Publication History Received3 August 2009Published online1 December 2006Published inissue 1 2006https://doi.org/10.1021/ed083p1761.1RIGHTS & PERMISSIONSArticle...