A5033513571- Forensic and Genetic Research
- Race, Genetics, and Society
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Digestive system and related health
- Metabolomics and Mass Spectrometry Studies
- Rangeland Management and Livestock Ecology
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Environmental DNA in Biodiversity Studies
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- Forest Management and Policy
- Arsenic contamination and mitigation
- HIV/AIDS Impact and Responses
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Yersinia bacterium, plague, ectoparasites research
- Animal Diversity and Health Studies
- Knowledge Societies in the 21st Century
- Bat Biology and Ecology Studies
- Demographic Trends and Gender Preferences
- Sensor Technology and Measurement Systems
- Agroforestry and silvopastoral systems
Centre for Palaeogenetics
2021-2024
Stockholm University
2021-2024
Hospital Universitario Virgen de la Arrixaca
2021-2023
Studi
2021-2023
Uppsala University
2017-2022
Institut de Biologia Evolutiva
2019
University of Cambridge
2014-2015
Stab Vida (Portugal)
2013-2014
Universidade do Porto
2013-2014
Southern Africa is consistently placed as a potential region for the evolution of Homo sapiens We present genome sequences, up to 13x coverage, from seven ancient individuals KwaZulu-Natal, South Africa. The remains three Stone Age hunter-gatherers (about 2000 years old) were genetically similar current-day southern San groups, and those four Iron farmers (300 500 present-day Bantu-language speakers. estimate that all modern-day Khoe-San groups have been influenced by 9 30% genetic admixture...
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, date the Y-chromosomal most recent common ancestor (MRCA) Africa at 254 (95% CI 192–307) kya and detect cluster major founder haplogroups narrow time interval 47–52 kya,...
Scandinavia was one of the last geographic areas in Europe to become habitable for humans after Last Glacial Maximum (LGM). However, routes and genetic composition these postglacial migrants remain unclear. We sequenced genomes, up 57× coverage, seven hunter-gatherers excavated across dated from 9,500–6,000 years before present (BP). Surprisingly, among Scandinavian Mesolithic individuals, data display an east–west gradient that opposes pattern seen other parts Europe. Our results suggest...
Island Southeast Asia has recently produced several surprises regarding human history, but the region's complex demography remains poorly understood. Here, we report ∼2.3 million genotypes from 1,028 individuals representing 115 indigenous Philippine populations and genome-sequence data two ∼8,000-y-old Liangdao in Taiwan Strait. We show that islands were populated by at least five waves of migration: initially Northern Southern Negritos (distantly related to Australian Papuan groups),...
The southern African indigenous Khoe-San populations harbor the most divergent lineages of all living peoples. Exploring their genomes is key to understanding deep human history. We sequenced 25 full from five populations, revealing many novel variants, that 25% variants are unique Khoe-San, and group harbors greatest level diversity across globe. In line with previous studies, we found several gene regions extreme values in genome-wide scans for selection, potentially caused by natural...
Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups the Philippines, including 25 diverse self-identified Negrito populations, along high-coverage genomes Australopapuans Ayta Magbukon Negritos. We possess highest level Denisovan ancestry world-∼30%-40%...
Analysis of microbial data from archaeological samples is a growing field with great potential for understanding ancient environments, lifestyles, and diseases. However, high error rates have been challenge in metagenomics, the availability computational frameworks that meet demands limited. Here, we propose aMeta, an accurate metagenomic profiling workflow DNA designed to minimize amount false discoveries computer memory requirements. Using simulated data, benchmark aMeta against current...
Abstract The expansion of people speaking Bantu languages is the most dramatic demographic event in Late Holocene Africa and fundamentally reshaped linguistic, cultural biological landscape continent 1–7 . With a comprehensive genomic dataset, including newly generated data modern-day ancient DNA from previously unsampled regions Africa, we contribute insights into this that started 6,000–4,000 years ago western Africa. We genotyped 1,763 participants, 1,526 speakers 147 populations across...
Abstract Background Human population history in the Holocene was profoundly impacted by changes lifestyle following invention and adoption of food-production practices. These triggered significant increases sizes expansions over large distances. Here we investigate Fulani, a pastoral extending throughout African Sahel/Savannah belt. Results Based on genome-wide analyses propose that ancestors Fulani experienced admixture between West group carrying both European North ancestries. This likely...
Bantu speech communities expanded over large parts of sub-Saharan Africa within the last 4000-5000 years, reaching different southern 1200-2000 years ago. The languages subdivide in several major branches, with belonging to Eastern and Western branches spreading Central, Eastern, Southern Africa. There is still debate whether this linguistic divide correlated a genetic distinction between speakers. During their expansion, speakers would have come into contact diverse local populations, such...
Southern African indigenous groups, traditionally hunter-gatherers (San) and herders (Khoekhoe), are commonly referred to as "Khoe-San" populations have a long history in southern Africa. Their ancestors were largely isolated up until ∼2,000 years ago before the arrival of pastoralists farmers Assessing relationships among regional Khoe-San groups has been challenging due admixture with immigrant that obscure past population affinities gene flow these autochthonous communities. We...
The Afrikaner population of South Africa is the descendants European colonists who started to colonize Cape Good Hope in 1600s. In early days colony, mixed unions between males and non-European females gave rise admixed children later became incorporated into either or Coloured populations Africa. Differences ancestry, social class, culture, sex ratio geographic structure led distinct characteristic admixture patterns populations. has a predominant composition, whereas more diverse...
Humans living in the Andes Mountains have been historically exposed to arsenic from natural sources, including drinking water. Enzymatic methylation of allows it be excreted more efficiently by human body. Adaptation high-arsenic environments via enhanced and excretion was first reported indigenous women Argentinean Andes, but whether adaptation is a general phenomenon across native populations remains unclear. Therefore, we evaluated has occurred Bolivian studying groups who belong...
Abstract With the largest genomic dataset to date of Bantu-speaking populations, including newly generated data modern-day and ancient DNA from previously unsampled regions in Africa, we shed fresh light on expansion peoples speaking Bantu languages that started ∼4000 years ago western Africa. We have genotyped 1,740 participants, 1,487 speakers 143 populations across 14 African countries, whole-genome sequences 12 Late Iron Age individuals. Our results show received significant gene-flow...
Hunter-gatherer lifestyles dominated the southern African landscape up to ~ 2000 years ago, when herding and farming groups started arrive in area. First, livestock, likely of East origin, appeared Africa, preceding arrival large-scale Bantu-speaking agro-pastoralist expansion that introduced West African-related genetic ancestry into Present-day Khoekhoe-speaking Namaqua (or Nama short) pastoralists show high proportions admixture, linking with Khoekhoe herders. Most other historical...
Abstract Analysis of microbial data from archaeological samples is a rapidly growing field with great potential for understanding ancient environments, lifestyles and disease spread in the past. However, high error rates have been long-standing challenge metagenomics analysis. This also complicated by limited choice microbiome specific computational frameworks that meet demands field. Here, we propose aMeta, an accurate Metagenomic profiling workflow designed primarily to minimize amount...