A5087163723- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Forensic and Genetic Research
- Genetic and phenotypic traits in livestock
- Forensic Anthropology and Bioarchaeology Studies
- Genetic diversity and population structure
- Wheat and Barley Genetics and Pathology
- Endometrial and Cervical Cancer Treatments
- Race, Genetics, and Society
- Genetic factors in colorectal cancer
- Animal Genetics and Reproduction
- Digestive system and related health
- Rangeland Management and Livestock Ecology
- Evolutionary Psychology and Human Behavior
- Yersinia bacterium, plague, ectoparasites research
- Chromosomal and Genetic Variations
- HIV/AIDS Impact and Responses
- melanin and skin pigmentation
- Livestock and Poultry Management
- Archaeology and ancient environmental studies
- Genomic variations and chromosomal abnormalities
- Skin Protection and Aging
- Pleistocene-Era Hominins and Archaeology
- Aging and Gerontology Research
Uppsala University
2017-2021
Science for Life Laboratory
2019
Johannes Gutenberg University Mainz
2014
Significance Eye, hair, and skin pigmentation are highly variable in humans, particularly western Eurasian populations. This diversity may be explained by population history, the relaxation of selection pressures, or positive selection. To investigate whether natural is responsible for depigmentation within Europe, we estimated strength acting on three genes known to have significant effects human pigmentation. In a direct approach, these estimates were made using ancient DNA from...
Paleogenomic and archaeological studies show that Neolithic lifeways spread from the Fertile Crescent into Europe around 9000 BCE, reaching northwestern by 4000 BCE. Starting 4500 a new phenomenon of constructing megalithic monuments, particularly for funerary practices, emerged along Atlantic façade. While it has been suggested emergence megaliths was associated with territories farming communities, origin social structure groups erected them remained largely unknown. We generated genome...
The southern African indigenous Khoe-San populations harbor the most divergent lineages of all living peoples. Exploring their genomes is key to understanding deep human history. We sequenced 25 full from five populations, revealing many novel variants, that 25% variants are unique Khoe-San, and group harbors greatest level diversity across globe. In line with previous studies, we found several gene regions extreme values in genome-wide scans for selection, potentially caused by natural...
Northeast Africa has a long history of human habitation, with fossil-finds from the earliest anatomically modern humans, and housing ancient civilizations. The region is also gate-way out Africa, as well portal for migration into Eurasia via Middle East Arabian Peninsula. We investigate population northeast by genotyping ~3.9 million SNPs in 221 individuals 18 populations sampled Sudan South combine this data published genome-wide surrounding areas. find strong genetic divide between...
Abstract Background Copy Number Variation (CNV) is a common form of genetic variation underlying animal evolution and phenotypic diversity across wide range species. In the mammalian genome, high frequency CNV differentiation between breeds may be candidates for population-specific selection. However, differentiation, selection its population genetics have been poorly explored in horses. Results We investigated patterns, gene annotation using Axiom® Equine Genotyping Array (670,796 SNPs)...
The Afrikaner population of South Africa is the descendants European colonists who started to colonize Cape Good Hope in 1600s. In early days colony, mixed unions between males and non-European females gave rise admixed children later became incorporated into either or Coloured populations Africa. Differences ancestry, social class, culture, sex ratio geographic structure led distinct characteristic admixture patterns populations. has a predominant composition, whereas more diverse...
Abstract Purpose: Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, with no effective treatment. The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and evaluation a large, fully annotated, patient cohort. Experimental Design: Fifty cases full clinicopathologic annotation were analyzed for gene expression (n = 50), copy-number variation (CNV, n 40), cell morphometry 39), protein 22). Gene ontology network...
Hunter-gatherer lifestyles dominated the southern African landscape up to ~ 2000 years ago, when herding and farming groups started arrive in area. First, livestock, likely of East origin, appeared Africa, preceding arrival large-scale Bantu-speaking agro-pastoralist expansion that introduced West African-related genetic ancestry into Present-day Khoekhoe-speaking Namaqua (or Nama short) pastoralists show high proportions admixture, linking with Khoekhoe herders. Most other historical...
Abstract Lactase persistence (LP) is a well-studied example of Mendelian trait under selection in some human groups due to gene-culture coevolution. We investigated the frequencies genetic variants linked LP Sudanese and South populations. These populations have diverse subsistence patterns, are dependent on milk various extents, not only from cows but also other livestock such as camels goats. sequenced 316-bp region involved regulating expression LCT gene chromosome 2, which encompasses...
Abstract Lactase persistence (LP) is a well-studied example of Mendelian trait under selection in some human groups due to gene-culture co-evolution. We investigated the frequencies genetic variants linked LP Sudanese and South populations. These populations have diverse subsistence patterns, are dependent on milk various extents, not only from cows, but also other livestock such as camels goats. sequenced 316bp region involved regulating expression LCT gene chromosome 2, which encompasses...
ABSTRACT The Afrikaner population of South Africa are the descendants European colonists who started to colonize Cape Good Hope in 1600’s. In early days colony, mixed unions between males and non-European females gave rise admixed children later became incorporated into either or “Coloured” populations Africa. Ancestry, social class, culture, sex ratio geographic structure affected admixture patterns caused different ancestry Coloured populations. has a predominant composition, whereas more...
Abstract Background Copy Number Variation (CNV) is a common form of genetic variation underlying animal evolution and phenotypic diversity across wide range species. In the mammalian genome, high frequency CNV differentiation between breeds may be candidates for population-specific selection. However, differentiation, selection its population genetics have been poorly explored in horses. Results We investigated patterns, gene annotation using Axiom® Equine Genotyping Array (670,796 SNPs)...
Abstract Background Copy Number Variation (CNV) is a common form of genetic variation underlying animal evolution and phenotypic diversity across wide range species. In the mammalian genome, high frequency CNV differentiation between breeds may be candidates for population-specific selection. However, differentiation, selection its population genetics have been poorly explored in horses. Results We investigated patterns, gene annotation using Axiom ® Equine Genotyping Array (670,796 SNPs)...
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<p>Table S1</p>
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<p>Table S1</p>
<div>AbstractPurpose:<p>Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, with no effective treatment. The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and evaluation a large, fully annotated, patient cohort.</p>Experimental Design:<p>Fifty cases full clinicopathologic annotation were analyzed for gene expression (<i>n</i> = 50), copy-number variation (CNV,...
<div>AbstractPurpose:<p>Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, with no effective treatment. The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and evaluation a large, fully annotated, patient cohort.</p>Experimental Design:<p>Fifty cases full clinicopathologic annotation were analyzed for gene expression (<i>n</i> = 50), copy-number variation (CNV,...
<p>Table S2</p>