A5012035138- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- CAR-T cell therapy research
- Virus-based gene therapy research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Race, Genetics, and Society
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Research and Treatments
- Wildlife Ecology and Conservation
- Plant and animal studies
- Chronic Myeloid Leukemia Treatments
- Historical and Archaeological Studies
- Yersinia bacterium, plague, ectoparasites research
- Pleistocene-Era Hominins and Archaeology
- Genetics, Aging, and Longevity in Model Organisms
- Phagocytosis and Immune Regulation
- Meat and Animal Product Quality
- Animal Genetics and Reproduction
Uppsala University
2015-2024
Science for Life Laboratory
2013-2022
Institut de Biologia Evolutiva
2019
Czech Academy of Sciences, Biology Centre
2019
Swedish University of Agricultural Sciences
2005-2015
University of Gothenburg
2011
Karolinska Institutet
2004
Significance The transition from a foraging subsistence strategy to sedentary farming society is arguably the greatest innovation in human history. Some modern-day groups—specifically Basques—have been argued be remnant population that connect back Paleolithic. We present, our knowledge, first genome-wide sequence data eight individuals associated with archaeological remains cultures El Portalón cave (Atapuerca, Spain). These emerged same group of people as other Early European farmers, and...
Scandinavia was one of the last geographic areas in Europe to become habitable for humans after Last Glacial Maximum (LGM). However, routes and genetic composition these postglacial migrants remain unclear. We sequenced genomes, up 57× coverage, seven hunter-gatherers excavated across dated from 9,500–6,000 years before present (BP). Surprisingly, among Scandinavian Mesolithic individuals, data display an east–west gradient that opposes pattern seen other parts Europe. Our results suggest...
Population genomic studies of ancient human remains have shown how modern-day European population structure has been shaped by a number prehistoric migrations. The Neolithization Europe associated with large-scale migrations from Anatolia, which was followed herders the Pontic steppe at onset Bronze Age. Southwestern one last parts continent reached these migrations, and populations this region show intriguing similarities to initial Neolithic migrants. Partly due climatic conditions that...
Immunotherapy (eg interferon α) in combination with tyrosine kinase inhibitors is currently clinical trials for treatment of chronic myeloid leukemia (CML). Cancer patients commonly have problems so called immune escape mechanisms that may hamper immunotherapy. Hence, to study the function system CML interest. In present paper we identified focus on those directly T cells since these are important control tumor progression. patient samples were investigated presence myeloid-derived...
Paleogenomic and archaeological studies show that Neolithic lifeways spread from the Fertile Crescent into Europe around 9000 BCE, reaching northwestern by 4000 BCE. Starting 4500 a new phenomenon of constructing megalithic monuments, particularly for funerary practices, emerged along Atlantic façade. While it has been suggested emergence megaliths was associated with territories farming communities, origin social structure groups erected them remained largely unknown. We generated genome...
CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G) CARs carrying CD28 or 4-1BB been investigated patients, preclinical studies suggest that third (3G) with both and enhanced capacity. However, little is known about the intracellular signaling pathways downstream of CARs. In present work, we analyzed capacity post antigen stimulation 2G 3G expanded better than upon repeated IL-2 autologous cells. An antigen-driven...
The genomic landscape of Stone Age Europe was shaped by multiple migratory waves and population replacements, but different regions do not all show similar patterns. To refine our understanding the dynamics before after dawn Neolithic, we generated analyzed sequence data from human remains 56 individuals Mesolithic, Eneolithic across Central Eastern Europe. We found that Mesolithic European populations formed a geographically widespread isolation-by-distance zone ranging to Siberia, which...
Authentication of ancient human DNA results is an exceedingly difficult challenge due to the presence modern contaminant sequences. Nevertheless, field genetics generates huge scientific and public interest, thus researchers are rarely discouraged by problems concerning authenticity such data. Although several methods have been developed purpose authenticating (aDNA) results, while they useful in faunal research, most proven complicated apply DNA. Here, we investigate detail reliability one...
Statins are compounds prescribed to lower blood cholesterol in millions of patients worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme mevalonate pathway that leads synthesis farnesyl pyrophosphate, a precursor for and source lipid moieties protein prenylation. The nematode Caenorhabditis elegans possesses lacks branch leading synthesis, thus represents an ideal organism specifically study noncholesterol roles pathway. Inhibiting reductase C. using statins or RNAi...
The Neolithic period is characterized by major cultural transformations and human migrations, with lasting effects across Europe. To understand the population dynamics in Scandinavia Baltic Sea area, we investigate genomes of individuals associated Battle Axe Culture (BAC), a Middle complex resembling continental Corded Ware (CWC). We sequenced 11 (dated to 3330–1665 calibrated before common era (cal BCE)) from modern-day Sweden, Estonia, Poland 0.26–3.24× coverage. Three were CWC contexts...
Summary Ancient DNA has the potential of adding dimension time to genetic studies. With a suitable sample set it should be possible follow changes over as they occur. To date, only limited number ancient studies that cover large span have been published, and all these used mitochondrial DNA. Here, we explore SNP typing way access coding nuclear genes. By targeting fragments minimal size, typed three polymorphic sites in 111 cattle remains spanning some 4000 years. We showed there decrease...
Polarized cell expansion plays an important role in plant morphogenesis. Tip growth is a dramatic form of this process, which widely used as model to study its regulation by RAC/ROP GTPase signalling. During the dominant haploid phase life cycle, moss Physcomitrella patens contains different types cells that expand tip growth. highly attractive experimental system because genome has been sequenced, and transgene integration homologous recombination occurs at frequencies allowing effective...
Malignant melanoma is a serious disease in both humans and dogs, the high metastatic potential results poor prognosis for many patients. Its similarities with human make spontaneous canine an excellent model comparative studies of novel therapies tumor biology. We report pilot study local adenovector CD40L (AdCD40L) immunogene treatment 19 cases (14 oral, 4 cutaneous, 1 conjunctival). Three patients were World Health Organization stage I, 2 II, 10 III, IV. One to 6 intratumoral injections...
In the period between 5,300 and 4,900 calibrated years before present (cal. BP), populations across large parts of Europe underwent a demographic decline
Adiponectin is an adipokine with insulin-sensitising actions in vertebrates. Its receptors, AdipoR1 and AdipoR2, are PAQR-type proteins 7-transmembrane domains topologies reversed that of GPCR's, i.e. their C-termini extracellular. We identified three adiponectin receptor homologs the nematode C. elegans, named paqr-1, paqr-2 paqr-3. These differently expressed intestine (the main fat-storing tissue), hypodermis, muscles, neurons secretory tissues, from which they could exert systemic...
Current approaches for treating metastatic malignant melanoma (MM) are not effective enough and associated with serious adverse events. Due to its immunogenicity, is an attractive target immunostimulating therapy. In this phase I/IIa study, local AdCD40L immunostimulatory gene therapy was evaluated in patients MM. adenovirus carrying the CD40 ligand. Patients that failed standard treatments were enrolled. Six received four weekly intratumoral injections. Next, nine low-dose cyclophosphamide...
Begomoviruses were detected in Nicaraguan fields of tomato ( Lycopersicon esculentum ) and adjacently growing plants pepper Capsicum annuum ), chilli C . baccatum cushaw Cucurbita argyrosperma Mexican fireplant Euphorbia heterophylla using polymerase chain reaction (PCR) universal begomovirus primers. All showing symptoms infected with begomoviruses, while only 30–46% the pepper, tested virus‐positive. No begomoviruses found potato. The virus species provisionally identified by sequencing...
Abstract Objectives In order to understand contacts between cultural spheres in the third millennium BC, we investigated impact of a new herder culture, Battle Axe arriving Scandinavia on people sub‐Neolithic hunter‐gatherer Pitted Ware culture. By investigating genetic make‐up culture from two types burials (typical and culture‐influenced burials), could determine migration influences. Methods We sequenced analyzed genomes 25 individuals typical with influences if different burial were...
Few complete human genomes from the European Early Upper Palaeolithic (EUP) have been sequenced. Using novel sampling and DNA extraction approaches, we sequenced genome of a woman "Peştera Muierii," Romania who lived ∼34,000 years ago to 13.5× coverage. The shows similarities modern-day Europeans, but she is not direct ancestor. Although her cranium exhibits both modern Neanderthal features, similar levels admixture (∼3.1%) most EUP humans only half compared ∼40,000-year-old Peştera Oase 1....
Abstract After the dispersal of modern humans ( Homo sapiens ) Out Africa , hominins with a similar morphology to that present-day initiated gradual demographic expansion into Eurasia. The mitogenome (33-fold coverage) Peştera Muierii 1 individual (PM1) from Romania (35 ky cal BP) we present in this article corresponds fully whilst exhibiting mosaic morphological features related both and Neandertals. We have identified PM1 as basal haplogroup U6*, not previously found any ancient or humans....