A5025729478- Lysosomal Storage Disorders Research
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Genomic variations and chromosomal abnormalities
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Lymphoma Diagnosis and Treatment
- Gene expression and cancer classification
- Uterine Myomas and Treatments
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Lung Cancer Research Studies
- Molecular Biology Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Alcohol Consumption and Health Effects
- Parathyroid Disorders and Treatments
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
Lund University
2007-2023
Uppsala University
2012-2022
Science for Life Laboratory
2011-2021
United Nations Industrial Development Organization
2020
Skåne University Hospital
2011-2018
TU Dortmund University
2012
Goethe University Frankfurt
2012
Leibniz Research Centre for Working Environment and Human Factors
2012
University Hospital Frankfurt
2012
Sahlgrenska University Hospital
2012
Abstract Purpose: Although the central role of immune system for tumor prognosis is generally accepted, a single robust marker not yet available. Experimental Design: On basis receiver operating characteristic analyses, markers were identified from 60-gene B cell–derived metagene and analyzed in gene expression profiles 1,810 breast cancer; 1,056 non–small cell lung carcinoma (NSCLC); 513 colorectal; 426 ovarian cancer patients. Protein RNA levels examined paraffin-embedded tissue 330 The...
Abstract. Homocysteine is a probably atherogenic amino acid, the fasting and post‐methionine load serum concentrations of which have been reported to be much lower in premenopausal women than men postmenopausal women. This difference has proposed explain reduced proneness vascular disease. We measured both free total plasma homocysteine postmethionine load, 169 healthy subjects. Twelve subjects (7%) had distinctly abnormal values. Among remaining 157 subjects, neither nor post‐load values or...
Abstract We studied the ability of various markers bone turnover to predict fracture in 1040 randomly recruited 75-year-old women. A total 178 women sustained at least one during follow-up (mean, 4.6 years). In elderly women, TRACP5b and urinary fragments osteocalcin are promising new for prediction fracture, particular, vertebral fracture. Introduction: Biochemical reflecting may improve fractures. Materials Methods: The 10 Malmö OPRA study was studied. Serum bone-specific alkaline...
In the present epidemiologic study 80 car or industrial spray painters with long-term low level exposure to organic solvents were examined and compared two matched reference groups of nonexposed workers (80 persons in each group). The aim was investigate possible effects solvent on health. investigation included psychiatric interviews, psychometric tests, neurological, neurophysiological ophthalmologic examinations, computed tomography brain. painters` previous carefully assessed by...
We describe a versatile high-performance liquid-chromatographic method for determining homocysteine and other plasma sulfhydryls. Using three different procedures preparation of plasma, we determined total, free (non-protein-bound), reduced forms homocysteine, cysteine, glutathione, cysteinylglycine, gamma-glutamylcysteine in human plasma. Sample involves disulfide reduction with dithiothreitol protein precipitation sulfosalicylic acid. The assay utilizes isocratic reversed-phase ion-pair...
Fifty years ago Berger made the first registrations of electrical activity brain with electrodes placed on intact skull. It immediately became clear that frequency content recorded signals plays an important role in describing these and also state brain. This paper briefly surveys main properties electroencephalogram (EEG), points out several influential factors. A number methods have been developed to quantify EEG order complement visual screening; are conveniently classified as being...
Noncoding RNA (ncRNA) constitutes a significant portion of the mammalian transcriptome. Emerging evidence suggests that it regulates gene expression in cis or trans by modulating chromatin structure. To uncover functional role ncRNA organization, we deep sequenced chromatin-associated RNAs (CARs) from human fibroblast (HF) cells. This resulted identification 141 intronic regions and 74 intergenic harboring CARs. The CARs show conservation across 44 species placental mammals. Functional...
Abstract We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using dilution series tumor cell line mixed with its paired normal data generated on Affymetrix Illumina platforms, including tumor-normal samples tumors characterized by fluorescent situ hybridization, we demonstrate high sensitivity specificity the detecting both minute gross imbalances heterogeneous samples.
It is generally agreed that traditional alcohol biomarkers lack in sensitivity to detect hazardous consumption. The present study was undertaken evaluate the ability of phosphatidylethanol (PEth) and markers moderate consumption distinguish between abstinence. Forty-four subjects, 32 females 12 males, were included study. They randomized abstention or Female participants consumed 150 ml red wine (equivalent 16 g alcohol) per 24 h male double amount. lasted for 3 months. Blood samples drawn...
Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some which might be caused defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particular patterns instability with response to therapy has been challenging. Here, we show that allelic-imbalanced copy-number aberrations (AiCNA) more prevalent TNBCs respond platinum-based chemotherapy, thus providing candidate predictive biomarker for...
In clinical practice as well research situations, it is of great importance to get reliable information about a patient's alcohol consumption. The aim the study was investigate correlation biomarkers (phosphatidylethanol [PEth], carbohydrate-deficient transferrin [CDT], γ-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase) retrospective diary-based self-reports examine whether possible correlate biomarker result more precise level consumption.One hundred sixty...
The reactive vascular-injuring amino acid homocysteine was measured in plasma samples from 79 well-characterized type 1 diabetic patients and 46 control subjects. Patients with proliferative retinopathy had higher levels (15.0 +/- 6.3 mumols l-1; mean SD, p less than 0.001; n = 42) those progressive during a two-year period (10.4 1.6 12), no or minimal (10.7 4.3 25), the subjects (11.0 3.4 l-1). Within group of increased were confined to that serum creatinine greater 115 l-1 and/or an...
Thirty jet fuel exposed workers selected according to exposure criteria and thirty nonexposed controls from a motor factory were examined, with special reference the nervous system, by occupational hygiene physicians, psychiatrists, psychologists, neurophysiologists. The subjects matched respect age, employment duration, education. Among mean duration was 17 years, 300 mg/m3 calculated as rough time-weighted average level. investigation revealed significant differences between groups for (a)...
Abstract Screening for gene copy‐number alterations (CNAs) has improved by applying genome‐wide microarrays, where SNP arrays also allow analysis of loss heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high‐resolution platforms: BAC (32K), oligonucleotide (185K, Agilent), and two (250K, Affymetrix 317K, Illumina). Cross‐platform comparison revealed 29 concordantly detected CNAs, including known recurrent alterations, which confirmed...
Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from OPRA study, high homocysteine level was associated with bone marker levels and low BMD at baseline. During mean 7-year follow-up, mortality, no clear association fracture existed.Recently, between serum (Hcy) an increased of described.Hcy were measured baseline in women, all 75 years old. Vitamin B(12), folate, cross-linking telopeptide type I collagen (CTX), TRACP5b,...
We describe a bioinformatic tool, Tumor Aberration Prediction Suite (TAPS), for the identification of allele-specific copy numbers in tumor samples using data from Affymetrix SNP arrays. It includes detailed visualization genomic segment characteristics and iterative pattern recognition number identification, does not require patient-matched normal samples. TAPS can be used to identify chromosomal aberrations with high sensitivity even when proportion cells is as low 30%. Analysis cancer...
Background High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], neutral loss heterozygosity. Moreover, comparison profiles from sequential patients' samples allows clonal evolution.Design Methods We screened 369 patients with newly diagnosed a population-based cohort using 250K single nucleotide polymorphism-arrays. Clonal evolution was evaluated...
Neuron specific enolase (NSE) is a recognized biomarker for assessment of neurological outcome after cardiac arrest, but its reliability has been questioned. Our aim was to investigate what influence storage samples and choice measuring methods may have on levels NSE in peripheral blood. Two serum were drawn simultaneously from 51 hypothermia treated arrest patients. One sample (original sample) analysed when collected, using the Diasorin-method (LIAISON®NSE, LNSE). The other frozen, stored...