A5001478610- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Appendicitis Diagnosis and Management
- Global Cancer Incidence and Screening
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Axon Guidance and Neuronal Signaling
- Pancreatitis Pathology and Treatment
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Hedgehog Signaling Pathway Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
Icelandic Cancer Society
2000-2025
Uppsala University Hospital
2005-2024
Surgical Science (Sweden)
2024
Uppsala University
2014-2024
National Cancer Registration Service
2017
Public Health England
2017
Karolinska Institutet
2005-2012
Lund University
2009-2012
Linköping University
2012
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2012
To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in treatment curatively operated rectal cancer patients.Of 1,168 randomly assigned patients Swedish Rectal Cancer Trial between 1987 1990, 908 had curative surgery; 454 these surgery alone, were administered (25 Gy 5 days) followed by within 1 week. Follow-up was performed matching against three nationwide registries (the Register, Hospital Discharge Cause Death Register).Median follow-up time 13...
To analyze the occurrence of subacute and late adverse effects in patients treated with preoperative irradiation for rectal cancer.The study population included 1,147 randomly assigned to radiation therapy or surgery alone Swedish Rectal Cancer Trial conducted 1987 through 1990. Patient data were matched against Hospital Discharge Register identify admitted hospital after primary treatment cancer. Patients known residual disease excluded, a recurrence censored 3 months before date...
The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as tissue type-specific when screening expression patterns in human normal cancer tissues using an antibody-based proteomics approach. In this respect, the SATB2 shows selective pattern of and, within cells epithelial lineages, is restricted to glandular lining lower gastrointestinal tract. primarily preserved colorectal origin, indicating that...
Abstract Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core pathways 1 . Here, to understand the functional and prognostic impact cancer-causing mutations, we analysed whole genomes transcriptomes 1,063 primary colorectal cancers population-based cohort with long-term follow-up. From 96 mutated genes, 9 were not previously implicated 24 had been linked any cancer. Two distinct patterns pathway co-mutations observed, timing analyses...
To analyze the occurrence of second cancers in patients with rectal cancer treated external radiotherapy (RT) addition to surgery.The analyses were based on Uppsala Trial (completed 1985), randomly assigned preoperative RT all stages or postoperative for stage II and III cancers, Swedish Rectal Cancer 1990), surgery alone. Patients from trials matched against Registry.A total 115 (7%) 1,599 developed 122 cancers. More a (relative risk [RR], 1.85; 95% CI, 1.23 2.78). A significant increased...
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression PDGF receptors on stromal CAFs associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification secreted glycoprotein stanniocalcin-1 (STC1) as mediator by function in setting colorectal cancer. PDGF-stimulated increased migration invasion cocultured cancer...
Background: The Swedish Colorectal Cancer Registry (SCRCR) is a national registry established in 1995 for rectal cancer, and also including colon cancer since 2007. Knowledge of the quality vital order to draw correct conclusions from studies based on registry. aim this study was assess completeness, timeliness, comparability validity SCRCR.Material methods: Completeness, timeliness were estimated. From SCRCR year 2008, 500 cases randomly selected examine 486 retrieved. Using hospital...
Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic biomarkers can noninvasively diagnose cancers. However, validation studies have reported ~10% sensitivity to detect stage I cancer in a screening population and specific types, such as brain or genitourinary tumors, remain undetectable. We investigated urine plasma free glycosaminoglycan profiles (GAGomes) tumor metabolism for multi-cancer early detection (MCED) of 14 types using 2,064 samples from...
Growth differentiation factor 15 (GDF15) belongs to the transforming growth beta superfamily and has been associated with activation of p53 pathway in human cancer. The aim this study was assess prognostic value GDF15 patients colorectal cancer (CRC). Immunohistochemistry tissue microarrays were used analyse protein expression 320 CRC. In a subgroup 60 patients, level plasma also measured using solid-phase proximity ligation assay. Patients CRC moderate high intensity immunostaining had...
We describe a bioinformatic tool, Tumor Aberration Prediction Suite (TAPS), for the identification of allele-specific copy numbers in tumor samples using data from Affymetrix SNP arrays. It includes detailed visualization genomic segment characteristics and iterative pattern recognition number identification, does not require patient-matched normal samples. TAPS can be used to identify chromosomal aberrations with high sensitivity even when proportion cells is as low 30%. Analysis cancer...
Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary data, blood tissue patients was therefore initiated 2010 by Uppsala Umeå Universities involving their corresponding University Hospitals, which are referral centers for one third Swedish population.Patients with selected types who treated at...
Background Differences in cancer survival between the Nordic countries have previously been reported. The aim of this study was to examine whether these differences outcome remain, based on updated information from five national registers.Materials and methods data used for analysis NORDCAN database focusing nine common cancers diagnosed 1990–2016 Denmark, Finland, Iceland, Norway Sweden with maximum follow-up through 2017. Relative (RS) estimated at 1 5 years using flexible parametric RS...
KRAS and BRAF mutations are prognostic predictive tools in metastatic colorectal cancer, but little is known about their value patients scheduled for cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC). Therefore, we analyzed the impact of with peritoneal metastases CRS HIPEC.In a consecutive series 399 HIPEC between 2009 2017, 111 subjects from primaries appendix, colon, or rectum were mutation 92 mutation.Mutation was present 51/111 (46%), mutated found 10/92...
Abstract Background The aim of the study was to analyse late gastrointestinal disorders necessitating hospital admission following rectal cancer surgery and determine their relationship preoperative radiation therapy. Methods Curatively treated patients participating in Swedish Rectal Cancer Trial during 1987–1990, randomized irradiation (454 patients) or alone (454), were matched against Hospital Discharge Registry. records for admitted with diagnoses reviewed. Results Irradiated had an...
Abstract Background Epidermal growth factor receptor inhibitor therapy is now approved for treatment of metastatic colorectal carcinomas (CRC) in patients with tumors lacking KRAS mutations. Several procedures to detect mutations have been developed. However, the analytical sensitivity and specificity these assays on routine clinical samples are not yet fully characterised. Methods The practical aspects applicability a KRAS- assay based Pyrosequencing were evaluated series 314 consecutive...
In cancer research the selection and definitions of survival endpoints are important yet they not used consistently. The aim this study was to compare different in patients with primary colorectal (CRC) understand effect second other on disease-free (DFS) calculations. A population-based cohort 415 CRC, 332 whom were treated curative intention between years 2000-2003, analysed. Events such as locoregional recurrence, distant metastases, cancers, death, cause death loss follow-up recorded....
The severity of the COVID-19 pandemic and subsequent mitigation strategies have varied across Nordic countries. In a joint population-based effort, we compared patterns new cancer cases notifications between countries during 2020. We used pathology to registries in Denmark, Faroe Islands, Finland, Iceland, Norway Sweden determine monthly numbers malignant situ tumours from January December 2020 2019 (2017-2019 for Iceland Islands). per month based on unique individuals with notifications....
BackgroundSurvival of patients with colon and rectal cancer has improved in all Nordic countries during the past decades. The aim this study was to further assess survival trends by age at diagnosis present additional measures.MethodsData on cases diagnosed between 1990 2016 were obtained from NORDCAN database. Relative estimated using flexible parametric models. Both age-standardized age-specific measures for women men models, as well reference-adjusted crude probabilities death life-years...
Helicobacter pylori infection is associated with a decreased risk of esophageal adenocarcinoma, and the decreasing prevalence such might contribute to increasing incidence this tumor. We examined hypothesis that eradication treatment H increases adenocarcinoma.