A5076746439- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Surfactants and Colloidal Systems
- Advanced Polymer Synthesis and Characterization
- Dementia and Cognitive Impairment Research
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Microtubule and mitosis dynamics
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Pickering emulsions and particle stabilization
- Glycosylation and Glycoproteins Research
- Acute Ischemic Stroke Management
- Calcium Carbonate Crystallization and Inhibition
- Pancreatic and Hepatic Oncology Research
- Material Dynamics and Properties
- Orthopaedic implants and arthroplasty
- Lanthanide and Transition Metal Complexes
- Medical Imaging and Pathology Studies
- Monoclonal and Polyclonal Antibodies Research
RELX Group (Netherlands)
2024
Karolinska Institutet
2020-2023
Karolinska University Hospital
2023
Memorial Sloan Kettering Cancer Center
2018-2020
Swedish Medtech
2020
Monash University
2018-2020
Australian Regenerative Medicine Institute
2020
Kettering University
2018
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011-2016
Eindhoven University of Technology
2009-2012
Biogenic calcium carbonate forms the inorganic component of seashells, otoliths, and many marine skeletons, its formation is directed by an ordered template macromolecules. Classical nucleation theory considers crystal to occur from a critical nucleus formed assembly ions solution. Using cryotransmission electron microscopy, we found that template-directed starts with prenucleation clusters. Their aggregation leads amorphous nanoparticles in These assemble at and, after reaching size,...
The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as tissue type-specific when screening expression patterns in human normal cancer tissues using an antibody-based proteomics approach. In this respect, the SATB2 shows selective pattern of and, within cells epithelial lineages, is restricted to glandular lining lower gastrointestinal tract. primarily preserved colorectal origin, indicating that...
Five-year survival after resection of colorectal cancer liver metastasis (CRLCM) is <30%. We recently found that aurora kinase A (AURKA) drives 20q gain-associated tumour progression and associated with disease recurrence. This study evaluates the prognostic value AURKA expression in CRCLM patients who underwent resection.Tissue microarrays (TMAs) were generated using formalin-fixed paraffin-embedded matched primary from a multi-institutional cohort between 1990 2010. Tissue stained for...
Expression levels of biomarkers are generally unknown at initial diagnosis.The development theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection nanomedicine and facilitate treatment inoperable patients or with acquired resistance.Herein, we report the star polymers, also known as nanostars, allow molecular imaging and/or endoradiotherapy based passive targeting via enhanced permeability retention (EPR)...
Objective: To investigate the individual and combined prognostic value of HIF1α, SLC2A1, vascular endothelial growth factor A (VEGFA) in a multi-institutional cohort patients with resected colorectal cancer liver metastasis (CRCLM). Background: In majority CRCLM, resection seems not to be curative, despite its curative intent. Overexpression hypoxia-inducible 1α (HIF1α), glucose transporter 1 (SLC2A1; also known as GLUT1), VEGFA has been associated tumor progression poor prognosis (CRC)....
Colorectal cancer (CRC) is the third most common worldwide. Accurately identifying stage II CRC patients at risk for recurrence an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression associated with poor survival in liver metastases. In this study prognostic value III colon examined.KCNQ1 mRNA assessed 90 (AMC-AJCCII-90) using microarray data. Subsequently, protein evaluated independent cohort 386 by immunohistochemistry tissue...
Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins patients with liver metastases correlate early disease recurrence. Such may predict a propensity for earlier stages of CRC.Gene expression profiling proteomics were used differentially expressed genes/proteins resected recurred within 6 months following surgery vs those did not recur >24 months. Expression identified stage II (n=243) III (n=176)...
// Kristiaan Lenos 1, 2 , Jeroen A.C.M. Goos 3 Ilona M. Vuist 4 Sjoerd H. den Uil 3, 5 Pien Delis-van Diemen 6 Eric J.Th. Belt 7 Hein B.A.C. Stockmann Herman Bril 8 Meike de Wit 9, Beatriz Carvalho Susan Giblett 10 Catrin A. Pritchard Gerrit Meijer Yvette van Kooyk 1 Remond J.A. Fijneman Sandra J. Vliet Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands Current address: Laboratory Experimental Oncology Radiobiology, Center for...
Human epidermal growth factor receptor 2 (HER2) is used as a tumor biomarker and therapeutic target. Pertuzumab an anti-HER2 antibody, its binding to cells requires HER2 be present at the cell membrane. However, cellular distribution of protein in gastric tumors dynamic, internalization decreases antibody cells. These features preclude use pretargeted strategies for molecular imaging therapy. We explored pharmacological modulation endocytosis strategy improve pertuzumab uptake HER2-positive...
A simple Ginzburg-Landau theory with a single, scalar order parameter is used to study the microscopic structure of microemulsions and sponge phases. The scattering intensity in both film bulk contrast, as well averages internal area S, Euler characteristic ${\mathrm{\ensuremath{\chi}}}_{\mathit{E}}$, mean curvature squared 〈${\mathit{H}}^{2}$〉, are calculated by Monte Carlo methods. results compared obtained from variational approach combination Gaussian random fields level surfaces. for...
Resection of colorectal cancer liver metastasis (CRCLM) with curative intent has long-term benefit in ∼40% cases. Prognostic biomarkers are needed to improve clinical management and reduce futile surgeries. Expression epidermal growth factor receptor (EGFR) prostaglandin-endoperoxide synthase 2 (PTGS2; also known as cyclooxygenase-2) been associated carcinogenesis survival. We investigated the prognostic value EGFR PTGS2 expression patients resected CRCLM. Formalin-fixed paraffin-embedded...
A modular copolymer platform based on two oxazole derivatives is presented. Post-polymerisation modifications revealed the potential to selectively modify individual side groups, providing access functional libraries in future.
// Jeroen A.C.M. Goos 1 , Veerle M.H. Coupé 3 Mark A. van de Wiel Begoña Diosdado 4 Pien M. Delis-Van Diemen Annemieke C. Hiemstra Erienne M.V. Cuba A.M. Beliën Willemien Menke - der Houven Oordt 5 Albert Geldof 2 Gerrit Meijer Otto S. Hoekstra Remond J.A. Fijneman on behalf of the DeCoDe PET Group Department Pathology, VU University Medical Center, Amsterdam, The Netherlands Radiology and Nuclear Medicine, Epidemiology Biostatistics, Cancer Institute, Oncology, * These authors have...
In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize therapies and related new developments in the field. Our group has earlier optimized evaluated vitro properties two radiotracers,[89Zr]Zr-(oxinate)4 [89Zr]Zr-DFO-NCS, for radiolabelling different types. Here, we performed microPET study assess cells rats these radiotracers. Human decidual stromal (hDSC) rat macrophages (rMac) were radiolabelled...
Abstract We report for the first time combination of ATRP and ring‐opening episulfide polymerization as a means to synthesize polysulfide‐based low‐dispersity amphiphilic block copolymers. The most significant finding is possibility perform under mild conditions using poly(propylene sulfide) macroinitiators, apparently without any copper sequestration by polysulfides. Using glycerol monomethacrylate (GMMA) hydrophilic monomer, polymers self‐assembled in colloidal structures with morphology...
Secretory leukocyte protease inhibitor (SLPI), a pleiotropic protein expressed by healthy intestinal epithelial cells, functions as an of NF-κB and neutrophil proteases exerts antimicrobial activity. We previously showed SLPI suppresses chemokine production in response to microbial contact. Increased expression was recently detected various types carcinoma. In addition, accumulating evidence indicates is favorable for tumor cells. view these findings the abundance colonic epithelium, we...
The collisions of neighboring membranes in lamellar phases leads to the formation passages, or "wormholes".We study shape and fluctuations these based on curvature model membranes.In particular, we calculate average radius, asphericity, free energy a wormhole.This requires careful analysis translational zero modes.The single wormhole is then used obtain density passages low-density limit.We find that increases as d~/~w ith increasing membrane separation d stack, decreases exponentially with...
There is a need to better characterise cell-based therapies in preclinical models help facilitate their translation humans. Long-term high-resolution tracking of the cells vivo often impossible due unreliable methods. Radiolabelling has advantage being able reveal cellular kinetics over time. This study aimed optimise synthesis radiotracers [89Zr]Zr-oxine (8-hydroxyquinoline) and [89Zr]Zr-DFO-NCS (p-SCN-Bn-Deferoxamine) perform direct comparison cell labelling efficiency using these...
Abstract To improve the signal‐to‐noise ratio of hypoxia positron emission tomography (PET) imaging, stimuli‐responsive polymers are designed for delivery PET tracer fluorine‐18 labeled fluoromisonidazole ([ 18 F]FMISO). Linear poly( N ‐(2‐(hydroxypropyl)methacrylamide)) functionalized with hydrazide linkers that form pH‐sensitive acyl hydrazone bonds after their conjugation to an [ F]FMISO ketone analogue. The release analogue from is considerably faster at a lower pH and its uptake...