A5017902199- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- biodegradable polymer synthesis and properties
- Antimicrobial agents and applications
- Inhalation and Respiratory Drug Delivery
- Sulfur Compounds in Biology
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Covalent Organic Framework Applications
- Lanthanide and Transition Metal Complexes
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Urinary Bladder and Prostate Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Synthetic Organic Chemistry Methods
- RNA Interference and Gene Delivery
- Pickering emulsions and particle stabilization
- Surfactants and Colloidal Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroendocrine regulation and behavior
- Lipid Membrane Structure and Behavior
- Advanced Drug Delivery Systems
Monash University
2016-2025
Lawrence Berkeley National Laboratory
2020-2023
University of California, Berkeley
2023
Australian Research Council
2016-2022
Australian Regenerative Medicine Institute
2015-2021
ARC Centre of Excellence in Advanced Molecular Imaging
2009-2021
NAACP Legal Defense and Educational Fund
2020
Monash Institute of Medical Research
2020
Parks Victoria
2019
University of Warwick
2013-2017
Abstract This highlight describes recent developments in reversible addition–fragmentation transfer (RAFT) polymerization. Succinct coverage of the RAFT mechanism is supplemented by details synthetic methodologies for making a wide range architectures ranging from stars to combs, microgels, and blocks. In addition, reactions different media such as emulsion ionic liquids receive attention. Finally, specific example novel material design briefly introduced, whereas polymers prepared via are...
We report a new approach for the facile synthesis of high-order multiblock copolymers comprising very short blocks. The entails sequential addition different monomers via an iterative single electron transfer–living radical polymerization technique, allowing nearly perfect control copolymer microstructure. It is possible to synthesize with unprecedented control, i.e., A-B-C-D-E-etc., without any need purification between 24 h block formation steps. To illustrate this concept, we model...
Materials which respond to biological cues are the subject of intense research interest due their possible application in smart drug delivery vehicles.
Abstract Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism CGRP-evoked peripheral pain remain unclear. By cell-selective RAMP1 gene deletion, we reveal that released from mouse cutaneous trigeminal fibers targets CLR/RAMP1 on surrounding Schwann cells to evoke periorbital...
The facile synthesis of 3-miktoarm star polymers and 1st generation mikto polymeric dendrimers using atom transfer radical polymerization (ATRP) "click" chemistry is demonstrated. ATRP was used to synthesize near uniform with Br chain ends, which were easily converted into azido groups. These polymer chains then attached a trifunctional alkyne molecule (tripropargylamine) click reactions in variety ways make the miktoarm stars dendrimers.
A series of thermosensitive copoly(oligoethylene oxide) acrylates with narrow polydispersities were prepared by the copolymerization oligo(ethylene acrylate and di(ethylene ethyl ether using reversible addition−fragmentation chain transfer polymerization (RAFT). These copolymers exhibit tunable LCST behavior over range 15−90 °C dependent on their monomer compositions. Subsequently, these grafted onto gold nanoparticle (GNP) surfaces yielding nanoparticles. The thermoresponsive properties...
A variety of functional polymer chains prepared by RAFT were directly grafted onto 5, 10, and 20 nm gold nanoparticles (AuNPs). The shell coating the AuNPs was densely packed because strong binding between trithioester groups on chain-ends gold. It found that due to nature significantly stretched compared their usual Gaussian coil conformation in water. This even evident for where ionic repulsion neighboring should be significant. Therefore, with such high grafting densities surface...
Controlled/living radical polymerization is an efficient technique for the synthesis of well-defined polymeric architectures, including copolymers, block stars, graft, and variations thereof. In this article, we report first time a decablock copolymer via simple iterative Cu(0)-mediated technique. approach, purification not required between chain extension steps, as each formation taken to full conversion. The final can be obtained with yield in mass ∼90%. Using traditional controlled/living...
Click and drug: A combination of orthogonal click reactions is employed for the preparation functional iron oxide nanoparticles (IONPs) that show unprecedented hyperthermia-induced drug release through a magnetically stimulated retro-Diels–Alder (rDA) process. Magnetic stimulation induces sufficient local energy in close proximity to cycloadduct initiate rDA
An environmentally friendly emulsion technique produces uniform nanoparticles with precise control over molecular weight and particle size.
A versatile and inexpensive photochemical platform for the preparation of high-order multiblock functional materials.
Abstract A series of water‐soluble thermoresponsive hyperbranched copoly(oligoethylene glycol)s were synthesized by copolymerization di(ethylene glycol) methacrylate (DEG‐MA) and oligo(ethylene (OEG‐MA, M w = 475 g/mol), with ethylene glycol dimethacrylate (EGD‐MA) used as the crosslinker, via reversible addition fragmentation chain transfer polymerization. Polymers characterized size exclusion chromatography nuclear magnetic resonance analyses. According to monomer composition, that is,...
Abstract Poly(oligoethylene glycol) methyl ether acrylate was polymerized via reversible addition fragmentation transfer polymerization (RAFT), and then chain extended in the presence of both a cross‐linker vinyl benzaldehyde (VBA), yielding monodisperse star polymers. The aldehyde groups core exploited to attach doxorubicin. drug loading controlled by amount VBA incorporated (until 28 wt% drug). doxorubicin release studied at pH = 5.5 7.4; conditions representative endosomal extra cellular...
The synthesis of well-defined high molecular weight block copolymers by sequential in situ chain extensions via Cu(0)-mediated living radical polymerization is reported. Optimal conditions for iterative formation were determined using model homopolymer quasiblock systems, including methyl acrylate (MA), ethyl (EA), and n-butyl (nBA; each DPn ≈ 100). PDI after extension was below 1.2, with good agreement between theoretical experimental weights, while the conversion monomer incorporation into...
This review highlights the substantial progress in syntheses and applications of filomicelles, an emerging nanomaterial with distinct useful properties.
A new iterative copper(0)-mediated radical polymerization approach is presented that represents a significant advance in the synthesis of high order multi-block star copolymers. The these materials can now be achieved yield and with controlled structural complexity, purification only required at last step. general, facile offers opportunity to synthesize copolymer stars.
In this article, the synthesis of well-defined, narrow polydispersity (PDI < 1.2) star polymersviaRAFT polymerisation is detailed. An 'arm-first' method described using a crosslinked nanogel core. The synthetic conditions and variables were thoroughly investigated optimised so that nearly quantitative arm incorporation was found to occur. parameters studied included polymerization time, molecular weight, nature solvent cross-linker.
Phosphorylation of alginate was achieved using a heterogeneous urea/phosphate reaction. The degree and stereoselectivity phosphorylation as well the effects on physical properties polysaccharide were investigated by Fourier transform infrared (FTIR) nuclear magnetic resonance (NMR) spectroscopies, inductively coupled plasma optical-emission spectroscopy (ICP-OES), size exclusion chromatography (SEC). Multidimensional NMR studies phosporylated revealed that M residues occurred predominantly...