A5038856042- Pain Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Antifungal resistance and susceptibility
- Neuropeptides and Animal Physiology
- Fungal Infections and Studies
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Migraine and Headache Studies
- Ion Channels and Receptors
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Antimicrobial agents and applications
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Vestibular and auditory disorders
New York University
2022-2023
Monash University
2018-2022
Center for Clinical Research (United States)
2022
Australian Research Council
2019-2022
ARC Centre of Excellence in Advanced Molecular Imaging
2021
NAACP Legal Defense and Educational Fund
2020
Australian Regenerative Medicine Institute
2018-2020
Universidad de Santiago de Chile
2018
The University of Texas Health Science Center at San Antonio
2010
Abstract Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism CGRP-evoked peripheral pain remain unclear. By cell-selective RAMP1 gene deletion, we reveal that released from mouse cutaneous trigeminal fibers targets CLR/RAMP1 on surrounding Schwann cells to evoke periorbital...
Iron oxide nanoparticles have been widely applied in biomedical applications for their unique physical properties. Despite the relatively mature synthetic approaches iron nanoparticles, surface modification strategies obtaining particles with satisfactory biofunctionality are still urgently needed to meet challenge of nanomedicine. Herein, we report a and biofunctionalization strategy oxide-based magnetic based on dibromomaleimide (DBM)-terminated polymer brushed polyethylene glycol (PEG)...
<italic>Candida albicans</italic> (<italic>C. albicans</italic>) is a common fungal pathogen causing both localised and systemic infections.
Peripheral and central neurons in the pain pathway are well equipped to detect respond extracellular stimuli such as pro-inflammatory mediators neurotransmitters through cell surface expression of receptors that can mediate rapid intracellular signaling. Following injury or infection, activation G protein-coupled (GPCRs) initiates signaling processes lead generation action potentials inflammatory responses cytokine secretion by immune cells. However, it is now appreciated events alone may...
Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid molecules. The integrity these can be influenced by signaling through G protein-coupled receptors (GPCRs) ion channels. Serotonin (5-HT) is an important vasoactive mediator tissue edema inflammation. However, mechanisms drive 5-HT-induced plasma extravasation are poorly defined. Transient Receptor Potential Vanilloid 4 (TRPV4) channel established enhancer GPCRs promote inflammation endothelial barrier...
Abstract Oral cancer pain is attributed to the release from cancers of mediators that sensitize and activate sensory neurons. Intraplantar injection conditioned media (CM) human tongue cell line HSC‐3 or OSC‐20 evokes nociceptive behavior. By contrast, CM noncancer lines, DOK, HaCaT are non‐nociceptive. Pain carried by extracellular vesicles (EVs) released cells. Depletion EVs reverses mechanical allodynia thermal hyperalgesia. non‐nociceptive lines become when reconstituted with EVs. Two...
Lipoprotein abnormalities are likely contributors to the high risk of cardiovascular disease in chronic kidney (CKD) population, although information is limited. Specifically, little known about lipoprotein during early stages diabetic disease. The aim this study was investigate relationship between lipoproteins and manifestations CKD 517 Type 2 diabetes mellitus (T2DM) patients who participated Insulin Resistance Atherosclerosis Study (IRAS).Lipoprotein were measured by conventional lipid...
Intrathecal administration of brain derived neurotrophic factor (BDNF) induces long-term potentiation (LTP) and generates long-lasting central sensitization in spinal cord thus mimicking chronic pain, but the relevance these observations to pain mechanisms is uncertain. Since C-fiber activation by a high-frequency subcutaneous electrical stimulation (SES) protocol causes release BDNF LTP, we propose that application such would be sufficient condition for generating BDNF-mediated...
Release of a photoactive Re(<sc>i</sc>) complex from polymer star <italic>via</italic> ketimine linkages gives improved phototoxicity.
A loss of neuroplastic control on nucleus accumbens (NAc) neuronal activity exerted by the medial prefrontal cortex (mPFC) through long-term depression (LTD) is involved in triggering drug-seeking behavior and relapse several substances abuse due to impaired glutamate homeostasis tripartite synapses core. To test whether this maladaptive mechanism underlies addiction-like induced young mice a high-fat diet (HFD), we utilized 28-days-old male fed HFD ad-libitum over 2 weeks, followed 5 days...
Abstract Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism CGRP-evoked pain remain unknown. By cell-selective RAMP1 gene deletion, we reveal that released from mouse cutaneous trigeminal fibers targets CLR/RAMP1 on surrounding Schwann cells to evoke periorbital mechanical...