A5004745458- Parathyroid Disorders and Treatments
- Phytoestrogen effects and research
- Vitamin D Research Studies
- Sulfur Compounds in Biology
- Dialysis and Renal Disease Management
- Trace Elements in Health
- Bone health and osteoporosis research
- Magnesium in Health and Disease
- Glutathione Transferases and Polymorphisms
- Folate and B Vitamins Research
- Bone health and treatments
- Aluminum toxicity and tolerance in plants and animals
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- Metabolism and Genetic Disorders
- Redox biology and oxidative stress
- Pharmacological Effects and Toxicity Studies
- Urban Planning and Valuation
- Genetic Syndromes and Imprinting
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Historical and Environmental Studies
- Alcohol Consumption and Health Effects
- Bariatric Surgery and Outcomes
AstraZeneca (United States)
2024
Sprint (United States)
2021
SPRINT
2021
The University of Texas Health Science Center at San Antonio
2006-2017
University of Basilicata
2017
Audie L. Murphy Memorial VA Hospital
2010-2016
The University of Texas Health Science Center at Houston
2012-2016
Murphy Oil Corporation (United States)
2013-2015
South Texas Veterans Health Care System
2009-2015
Memorial Hospital
2013-2015
Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role in the pathogenesis of diabetic nephropathy (DN). The efficacy Nox1/Nox4 inhibitor GKT137831 on manifestations DN was studied OVE26 mice, model type 1 diabetes. Starting at 4–5 mo age, mice were treated with 10 or 40 mg/kg, once-a-day for 4 wk. At both doses, inhibited oxidase activity, superoxide generation, and hydrogen peroxide production renal cortex from without affecting Nox1 Nox4 protein expression....
Podocyte injury, a major contributor to the pathogenesis of diabetic nephropathy, is caused at least in part by excessive generation reactive oxygen species (ROS). Overproduction superoxide NADPH oxidase isoform Nox4 plays an important role podocyte injury. The plant extract silymarin attributed antioxidant and antiproteinuric effects humans animal models nephropathy. We investigated effect silybin, active constituent silymarin, cultures mouse podocytes OVE26 mouse, model type 1 diabetes...
Aims Many patients with heart failure (HF) have chronic kidney disease (CKD) and may not tolerate mineralocorticoid receptor antagonists. We investigated the efficacy safety of novel modulator balcinrenone in combination dapagliflozin a phase 2b study. Methods results From January 2021 to October 2023, we randomized 133 adults symptomatic HF, ejection fraction <60%, estimated glomerular filtration rate (eGFR) ≥30 ≤60 ml/min/1.73 m 2 urinary albumin‐to‐creatinine ratio (UACR) <3000...
Evidence has accumulated suggesting that the state of secondary hyperparathyroidism and elevated blood levels parathyroid hormone (PTH) in uremia participate genesis many uremic manifestations. The present study examined role PTH glucose intolerance chronic renal failure (CRF). Intravenous tolerance tests (IVGTT) euglycemic hyperglycemic clamp studies were performed dogs with CRF (NPX) without glands (NPX-PTX). There no significant differences among plasma concentrations electrolytes, degree...
Inflammation is commonly associated with malnutrition and cardiovascular disease in end-stage renal failure patients. Anti-inflammatory properties of the isoflavones, a micronutrient component soy, have been reported several experimental models conditions, but never failure. We hypothesized that dietary soy isoflavones correct laboratory evidence systemic inflammation haemodialysis (HD) patients underlying high blood levels C-reactive protein (CRP).End-stage on chronic HD, elevated CRP...
Administration of ferric pyrophosphate citrate (FPC, Triferic™) via hemodialysate may allow replacement ongoing uremic and hemodialysis-related iron losses. FPC donates directly to transferrin, bypassing the reticuloendothelial system avoiding sequestration. Two identical Phase 3, randomized, placebo-controlled trials (CRUISE 1 2) were conducted in 599 iron-replete chronic hemodialysis patients. Patients dialyzed with dialysate containing 2 µM FPC-iron or standard (placebo) for up 48 weeks....
Abstract The beagle dog model has been established by our laboratory as a useful animal to study bone loss after cessation of ovarian function. Previously we demonstrated associated with an osteoblastic insufficiency at 4 months ovariohysterectomy (OHX). This was designed evaluate four sequential monthly biopsies the development and course histologic abnormalities OHX. We found cancellous volume, trabecular density, wall thickness be decreased (p &lt; 0.05) separation increased early 1...
To study aluminum-related bone disease, biopsies and serum biochemical measurements were done in 97 patients on maintenance dialysis 100 with mild to moderate renal failure. Bone histology, histochemical staining for aluminum determination of content done. Stainable was found 50% dialyzed 5% nondialyzed patients. The finding stainable associated high morbidity mortality; it not only seen most low turnover osteomalacia, but also 47% mixed uremic osteodystrophy 1 patient predominant...
The singular and combined effects of 1,25-dihydroxyvitamin D [1,25-(OH)2D] PTH on bone were evaluated in a long term vivo study dogs. Dogs rendered deficient 1,25-(OH)2D by five sixths nephrectomy parathyroidectomy. A control group was sham operated. Various combinations status produced daily sc injections (1.25) and/or continuous infusion 1-34 bovine PTH. These 1.25+/PTH+, 1.25−/PTH−, 1.25+/PTH−, 1.25−/PTH+. Serum calcium levels kept the normal range administration one or two hormones oral...