A5084531687- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Orthopaedic implants and arthroplasty
- Mesenchymal stem cell research
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Nerve injury and regeneration
- CAR-T cell therapy research
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Printing in Biomedical Research
- Xenotransplantation and immune response
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
Karolinska Institutet
2021-2024
Heart failure has a poor prognosis and no curative treatment exists. Clinical trials are investigating gene- cell-based therapies to improve cardiac function. The safe efficient delivery of these solid organs is challenging. Herein, we demonstrate the feasibility using an endovascular intramyocardial approach safely administer mRNA drug products perform cell transplantation procedures in swine. Using
In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize therapies and related new developments in the field. Our group has earlier optimized evaluated vitro properties two radiotracers,[89Zr]Zr-(oxinate)4 [89Zr]Zr-DFO-NCS, for radiolabelling different types. Here, we performed microPET study assess cells rats these radiotracers. Human decidual stromal (hDSC) rat macrophages (rMac) were radiolabelled...
There is a need to better characterise cell-based therapies in preclinical models help facilitate their translation humans. Long-term high-resolution tracking of the cells vivo often impossible due unreliable methods. Radiolabelling has advantage being able reveal cellular kinetics over time. This study aimed optimise synthesis radiotracers [89Zr]Zr-oxine (8-hydroxyquinoline) and [89Zr]Zr-DFO-NCS (p-SCN-Bn-Deferoxamine) perform direct comparison cell labelling efficiency using these...
Cell therapy is an integral modality of regenerative medicine. Macrophages are known for their sensitivity to activation stimuli and capability recruit other immune cells the sites injury healing. In addition, route administration can impact engraftment efficacy cell therapy, modern neuro-interventional techniques provide possibility selective intra-arterial (IA) delivery central nervous system (CNS) with very low risk. The effects radiolabelling catheter transport on differentially...