A5100609526- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- MicroRNA in disease regulation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Retinal Diseases and Treatments
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Thermochemical Biomass Conversion Processes
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Conducting polymers and applications
- Electrochemical Analysis and Applications
- Electrochemical sensors and biosensors
- Lignin and Wood Chemistry
- Angiogenesis and VEGF in Cancer
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Multiple Myeloma Research and Treatments
- Molecular Sensors and Ion Detection
Xidian University
2018-2025
Guangdong University of Technology
2025
Nanyang Institute of Technology
2025
Tianjin University of Science and Technology
2017-2025
Peking University
2011-2024
Peking University Third Hospital
2011-2024
Bridge University
2024
Shandong University of Science and Technology
2022-2024
Qingdao University of Science and Technology
2022-2024
Beijing Technology and Business University
2024
In the conserved autophagy pathway, autophagosomes (APs) engulf cellular components and deliver them to lysosome for degradation. Before fusing with lysosome, APs have close via an unknown mechanism. We previously shown that endocytic Rab5-GTPase regulates AP closure. Therefore, we asked whether ESCRT, which catalyzes scission of vesicles into late endosomes, mediates topologically similar process sealing. Here, show depletion representative subunits from all ESCRT complexes causes defects...
Abstract Construction of bifunctional catalysts with balanced adsorption toward multiple reactants and intermediates is crucial for efficient urea‐assisted water splitting. Nickel Sulfide (NiS) considered as a promising choice both urea oxidation reaction (UOR) hydrogen evolution (HER), whereas the highly occupied d orbital Ni sites results in too weak reactant to achieve satisfactory bifunctionality. Herein, considering adsorption‐energy scaling limitations, another Mo 4+ site empty...
Engineering the liver in vitro is promising to provide functional replacement for patients with failure, or tissue models drug metabolism and toxicity analysis. In this study, we describe a microfluidics-based biomimetic approach fabrication of an 3D lobule-like microtissue composed radially patterned hepatic cord-like network intrinsic sinusoid-like network. The enzyme assay showed that maintained high basal CYP-1A1/2 UGT activities, responded dynamically induction/inhibition, preserved...
During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces including fluid shear stress (FSS) while en route distant sites. However, prior work indicates that more resistant brief pulses of high-level FSS in vitro relative non-transformed epithelial cells. Herein, we identify a mechano-adaptive mechanism resistance Our findings demonstrate activate RhoA response FSS, which protects them from FSS-induced plasma membrane damage. We show freshly isolated mouse and...
The outermost surface of wool is covered by a scale layer, posing challenges to some steps fabric processing. This primarily composed keratin, resists degradation conventional proteases due its high disulfide bond content. Protease K, an extracellular serine endo-proteinase derived from Tritirachium album Limber (tPRK), known for ability digest native keratin. However, limited activity against keratin has restricted application in layer treatment. In this study, the substrate-binding pocket...
We present a multistage microfluidic device for continuous label-free separation of rare cells using combination inertial microfluidics and steric hindrance.
Patients with malignant melanoma have a five‐year survival rate of only 15–20% once the tumor has metastasized to distant tissues. While MAP kinase pathway inhibitors (MAPKi) are initially effective for majority patients harboring BRAFV600E mutation, over 90% relapse within two years. Thus, there is critical need understanding MAPKi resistance mechanisms. In this manuscript, we performed forward genetic screen using whole genome shRNA library identify negative regulators vemurafenib...
Surface-enhanced Raman scattering (SERS) technology, as an important analytical tool, has been widely applied in the field of chemical and biomedical sensing. Automated testing is often combined with biochemical analysis technologies to shorten detection time minimize human error. The present SERS substrates for sample are time-consuming subject high error, which not conducive combination automated testing. Here, a novel honeycomb-inspired microarray designed large-area urease saliva samples...
It is proposed that a progressive series of mutations and epigenetic events leads to human colorectal cancer (CRC) metastasis. Furthermore, data from resequencing the coding regions CRC suggests relatively large number occur in individual CRC, most at low frequency. The functional role these low-frequency specifically how they may cooperate with high-frequency mutations, not well understood. One common rate-limiting occurs adenomatous polyposis coli ( APC ) gene. To identify mutant , we...
The purpose of this study was to investigate which inflammation-based marker more accurately predict recurrence in patients receiving hepatectomy for hepatocellular carcinoma (HCC).A total 1020 included. impacts clinical variables and markers on disease-free survival (DFS) were measured by Kaplan-Meier method. Selected potential prognostic factors further analyzed multivariate model. To reduce influences selection bias possible confounders, characteristics balanced propensity score matching...
The development and application of miniaturized platforms with the capability for microscale dynamic control biomimetic high-throughput three-dimensional (3D) culture plays a crucial role in biological research. In this study, pneumatic microstructure-based microfluidics was used to systematically demonstrate 3D tumor under various conditions. We also demonstrated reusability fabrication-optimized device cell manipulation culture. This microfluidic system provides remarkably long-term (over...
// Mu Hao 1, 2 , Meirong Zang 1 Lei Zhao 3 Shuhui Deng Yan Xu Fang Qi Gang An Yu Qin Weiwei Sui Fei Li Wenjuan Yang Zengjun Shuhua Yi Dehui Zou Fenghuang Zhan Lugui Qiu State Key Laboratory of Experimental Hematology, Institute Hematology and Blood Diseases Hospital, Chinese Academy Medical Science Peking Union College, Tianjin 300020, China Division Oncology, Marrow Transplantation, Department Internal Medicine, University Iowa, Iowa City, IA 52242, USA Molecular Physiology Biophysics,...
AIM: To clarify this controversy and to provide evidence for application of lipid lowering agents in treatment diabetic retinopathy (DR). METHODS: We searched the databases PubMed, Embase Cochrane Library Central Register Controlled Trials (CENTRAL) abstracts from main annual meetings up January 1, 2017. Google scholar ClinicalTrials.gov were also unpublished relevant studies. included randomized controlled trials (RCTs) that studied lipid-lowering type 1 or 2 diabetes Meta-analysis. The...
A novel, facile, and flexible approach for the easy assembly of microfluidic droplet devices using commercially available components is presented. Three different types have been designed tested, experimental results indicated that offer a promising platform controllable generation highly monodisperse droplets with sizes in micrometer to millimeter diameter ranges. The advantages include their low cost, portability, reusability, high accuracy, reliability. Most importantly, simple reversible...
Limitation of 3D construction ability, complex preparation processes and developing customer demands have promoted people to find low-cost, rapid prototyping, simple operation methods produce novel functional devices in the near future. Among various techniques, 3D-printed technology is a promising candidate for fabrication biosensors biomedical detection with wide variety potential applications. This review offers four important printing techniques their The principle process technologies...
Polydiacetylene (PDA) materials have been adopted as one of the powerful conjugated polymers for sensing applications due to their unique optical properties. In this paper, we present a new PDA liposome-based sensor system with enhanced fluorescent self-amplification by tuning fluorophore fluorescence emission. system, 1,8-naphthalimide derivative employed highly was incorporated into supermolecule. During formation blue liposomes, emission can be directly quenched, while thermal-induced...
Objective The aim of this retrospective study was to explore the correlation between daily energy intake from macronutrients and cognitive functions in a Chinese population aged less than 65 years. Design This is cross-sectional relationships macronutrients' function. analysis variance (ANOVA) χ 2 test were used compare demographic physical characteristics, lifestyle laboratory parameters with among different quartiles % fat/energy. Multivariate logistic regression applied identify potential...
Atherosclerosis is widely known to be a chronic inflammatory disease. C‐reactive protein (CRP), an important factor, plays essential role in the pathogenesis of atherosclerosis. Nicotine, main addictive component cigarette, has been shown induce production CRP. The aim this study was investigate effect rosmarinic acid (RA), polyphenol with antiinflammatory activity, on nicotine‐induced elevation CRP vascular smooth muscle cells (VSMCs). We found that pretreatment VSMCs RA attenuated...