A5029764881- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Caveolin-1 and cellular processes
- MicroRNA in disease regulation
Lund University
2016-2025
Skåne University Hospital
2014-2024
Malmö University
2007-2023
Dana-Farber Cancer Institute
2008-2023
CREATe Centre
2023
OncoMark (Ireland)
2016-2019
Trinity College Dublin
2019
St. Vincent's University Hospital
2012-2019
Aarhus University Hospital
2019
University College Dublin
2006-2018
Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell in breast represent prognostic indicators for recurrence-free overall survival. We provide evidence response to chemotherapy is part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells produce monocyte/macrophage recruitment factors, including colony stimulating factor 1 (CSF1) interleukin-34, which together...
Tissue-based diagnostics and research is incessantly evolving with the development of new molecular tools. It has long been realized that immunohistochemistry can add an important level information on top morphology protein expression patterns in a cancer may yield crucial diagnostic prognostic information. We have generated immunohistochemistry-based map profiles normal tissues, cell lines. For each antibody, altogether 708 spots tissues cells are analysed resulting images data presented as...
Tumor associated macrophages (TAMs) are alternatively activated that enhance tumor progression by promoting cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for In this study we evaluated the specificity of using macrophage TAM compared its prognostic value with more frequently used pan-macrophage CD68. We also analyzed localization CD163+ CD68+ myeloid cells in...
Abstract Purpose: We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in ovarian cancer via abrogation a tumor-promoting cytokine network. Experimental Design: combined preclinical and silico experiments with phase 2 clinical trial the anti-IL-6 antibody siltuximab patients platinum-resistant cancer. Results: Automated immunohistochemistry on tissue microarrays from 221 cases showed that intensity IL-6 staining malignant cells significantly associated poor...
The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as tissue type-specific when screening expression patterns in human normal cancer tissues using an antibody-based proteomics approach. In this respect, the SATB2 shows selective pattern of and, within cells epithelial lineages, is restricted to glandular lining lower gastrointestinal tract. primarily preserved colorectal origin, indicating that...
Multiple studies have described associations between infiltrating immune cells and prognosis in cancer; however, the clinical relevance has most often been attributed to T-cell linage. This study aimed further investigate clinicopathological correlates prognostic impact of B cell plasma infiltration CRC. Immunohistochemical expression CD20, CD138 immunoglobulin kappa C (IGKC) was analysed tissue microarrays with tumours from 557 incident cases CRC a prospective population-based cohort....
Four randomized studies show that adjuvant radiotherapy (RT) lowers the risk of subsequent ipsilateral breast events (IBEs) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) by approximately 50% 10 to 15 years. We present 20 years follow-up data SweDCIS trial.Between 1987 and 1999 1,046 women were randomly assigned RT or not BCS primary DCIS. Results up 2005 have been published, we now add another 7 follow-up. All cancer causes death registered.There 129 invasive...
p21-activated kinase 1 (Pak1) phosphorylates many proteins in both normal and transformed cells. Its ability to phosphorylate thereby activate the estrogen receptor alpha (ERalpha) potentially limits effectiveness of antiestrogen treatment breast cancer. Here we studied associations between Pak1 expression subcellular localization tumor cells tamoxifen resistance.Pak1 protein was evaluated 403 primary tumors from premenopausal patients who had been randomly assigned 2 years adjuvant or no...
Systemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), are mobilized into the circulation and subsequently foster growth of otherwise indolent carcinoma (responders) residing at distant anatomical sites. The identity BMCs their specific contribution or contributions to responder tumor have been elusive. Here, we demonstrated that Sca1+ cKit- hematopoietic mouse hosts bearing instigating promote responding form with...
It is well established that parity and use of oral contraceptives reduce the risk ovarian cancer, but associations with other reproductive variables are less clear. We examined contraceptive factors cancer in European Prospective Investigation into Cancer Nutrition. Among 327 396 eligible women, 878 developed over an average 9 years. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre age, adjusted for smoking status,...
Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well informative biology. Herein, employed population-based metastatic melanoma cohort external cohorts determine the prognostic significance phenotypes. We performed profiling 214...
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression PDGF receptors on stromal CAFs associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification secreted glycoprotein stanniocalcin-1 (STC1) as mediator by function in setting colorectal cancer. PDGF-stimulated increased migration invasion cocultured cancer...
Abstract Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal (IDC), accounting for around 10% of all cancers. The molecular processes that drive development ILC are still largely unknown. We have performed a comprehensive genomic, transcriptomic and proteomic analysis large patient cohort present here an integrated portrait ILC. Mutations in CDH1 PI3K pathway frequent alterations identified two main subtypes ILCs:...
Abstract Triple-negative (TN) breast cancers (ER − PR HER2 ) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours infiltration of inflammatory cells even more aggressive. The effect myeloid on reactive stroma formation in TN cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate vivo develop into immunosuppressive expressing the myeloid-derived suppressor cell marker S100A9 only...
The role of intercellular tight junctions in breast epithelial cells is traditionally thought to be maintaining polarity and barrier function. However, claudin-4, a junction protein, overexpressed tumour compared normal cells, which generally corresponds loss polarity. aim this study was investigate the distribution potential clinical value claudin-4 cancer, evaluate its usefulness as prognostic predictive biomarker. Expression initially examined by Western blot analysis cohort 88 tumours,...
Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that examined this hypothesis yielded inconsistent results, possibly because most been of insufficient size to identify heterogeneous associations with precision.
A well-orchestrated inflammatory reaction involves the induction of effector functions and, at a later stage, an active downregulation this potentially harmful process. In study we show that under proinflammatory conditions noncanonical Wnt protein, Wnt5a, induces immunosuppressive macrophages. The suppressive phenotype induced by Wnt5a is associated with IL-10 and inhibition classical TLR4-NF-κB signaling. Interestingly, closely resembles observed in reprogrammed monocytes sepsis patients....
Abstract Purpose: Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or benefit. The DCISionRT biological signature developed this study provides recurrence predicts radiotherapy (RT) benefit for DCIS following breast-conserving surgery (BCS). Experimental Design: A that calculates an individualized Decision Score (DS) was cross-validated 526 treated BCS ±...
Claudins (CLDNs) are central components of tight junctions that regulate epithelial‐cell barrier function and polarity. Altered CLDN expression patterns have been demonstrated in numerous cancer types lineage‐specific CLDNs proposed as therapy targets. The objective this study was to assess which fraction patients with non‐small‐cell lung (NSCLC) express CLDN6 CLDN18 isoform 2 (CLDN18.2). Protein CLDN18.2 examined by immunohistochemistry on a tissue microarray ( n = 355) transcript levels...