A5037723076- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- TGF-β signaling in diseases
- Digestive system and related health
- Angiogenesis and VEGF in Cancer
- Esophageal Cancer Research and Treatment
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- COVID-19 and healthcare impacts
- Medical Imaging and Pathology Studies
Lund University
2012-2024
Skåne University Hospital
2012-2021
There are several indications that the composition of tumor stroma can contribute to malignancy a tumor. Here we utilized expression data sets identify metagenes may serve as surrogate marker for extent matrix production and vascularization characterize prognostic molecular components stroma. TCGA from six cancer forms, two breast microarray one mRNA set xenografted tumors were downloaded. Using mean correlation distance measure compact clusters with genes representing extracellular (ECM...
// Anna Karlsson 1 , Hans Brunnström 2, 3 Kajsa Ericson Lindquist Karin Jirström Mats Jönsson Frida Rosengren Christel Reuterswärd Helena Cirenajwis Åke Borg 1, 6 Per 4 Maria Planck 5 Göran Johan Staaf Division of Oncology and Pathology, Department Clinical Sciences Lund, Lund University, Medicon Village, SE 22381 Sweden 2 22185 Regional Laboratories Region Skåne, Thoracic Surgery, Skåne University Hospital, Oncology, Create Health Strategic Center...
Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms. SATB1 expression demonstrated correlate unfavourable tumour characteristics rectal cancer, but its association clinical outcome colorectal (CRC) remains unclear. In this study, we examined the prognostic impact of CRC, important molecular characteristics; i.e. beta-catenin overexpression, microsatellite...
Despite their pivotal roles in colorectal carcinogenesis, the interrelationship and prognostic significance of beta-catenin alterations microsatellite instability (MSI) cancer (CRC) needs to be further clarified. In this paper, we studied associations between overexpression MSI status with survival from CRC, expression p21, p27, cyclin D1 p53, a large, prospective cohort study. Immunohistochemical MSI-screening p27 p53 was assessed tissue microarrays tumours 557 cases incident CRC Malmö Diet...
// Kajsa Ericson Lindquist 1, * , Anna Karlsson 2, Per Levéen 1 Hans Brunnström 3 Christel Reuterswärd 2 Karolina Holm Mats Jönsson Karin Annersten Frida Rosengren Jirström Jaroslaw Kosieradzki 4 Lars Ek Åke Borg 5 Maria Planck 6 Göran and Johan Staaf Department of Pathology, Regional Laboratories Region Skåne, Lund SE 22185, Sweden Division Oncology Clinical Sciences Lund, University, Medicon Village, 22381, Respiratory Medicine Allergology, Skane University Hospital, SE22185, CREATE Health...
Activating KRAS and BRAF mutations predict unresponsiveness to EGFR-targeting therapies in colorectal cancer (CRC), but their prognostic value needs further validation. In this study, we investigated the impact of codons 12 13, on survival from CRC, overall stratified by sex, a large prospective cohort study.KRAS were analysed pyrosequencing tumours 525 524 incident CRC cases The Malmö Diet Cancer Study. Associations with cancer-specific (CSS) explored Cox proportional hazards regression,...
Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown a corresponding period in 2019, terms tissue and/or plasma-based test workload, analytical platforms adopted, number cases undergoing programmed...
Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use cell line slides mimicking samples. In this international multi-institutional study, gene fusion reference standards were developed and validated.Cell lines harbouring EML4(13)-ALK(20) SLC34A2(4)-ROS1(32) adopted to prepare standards. Eight laboratories (five adopting amplicon-based three hybridisation-based...
Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response. Following our previous investigation cytological samples, the aim of this study was further explore potential impacts various clinicopathological and molecular factors...
Accurate and reliable diagnosis is essential for lung cancer treatment. The study aim was to investigate interpathologist diagnostic concordance pulmonary tumours according WHO criteria.Fifty-two unselected bronchial biopsies were diagnosed by a thoracic pathologist based on broad spectrum of immunohistochemical (IHC) stainings, molecular data clinical/radiological information. Slides stained with H&E, thyroid transcription factor-1 (TTF-1) clone SPT24 p40 scanned provided digitally 20...
Objectives: Accurate and reliable diagnostics are crucial as histopathological type influences selection of treatment in lung cancer. The aim this study was to evaluate real-world accuracy use immunohistochemical (IHC) staining cancer diagnostics. Materials Methods: diagnosis used IHC stains for small specimens with on follow-up resection were retrospectively investigated a 15-month period at two major sites Sweden. Additionally, 10 pathologists individually suggested diagnostic 15 scanned...
Mutation analysis by massive parallel sequencing (MPS) is routinely performed in the clinical management of lung cancer Sweden. We describe and mutational profiles patients subjected to first 1.5 years treatment predictive MPS testing an autonomous regional health care region.Tumors from all with who had test January 2015 June 2016 Skåne region Sweden (1.3 million citizens) were included. Six hundred eleven tumors 599 profiled using targeted a 26-gene exon-focused panel. Data on disease...
Lymph node fine-needle aspiration cytology (LN-FNAC) is a common, rapid, minimally invasive and cost-effective diagnostic method. For mediastinal lymph nodes, endobronchial ultrasound (EBUS) guided LN-FNAC first-line investigation has an indispensable role in the diagnosis staging of patients with suspected lung cancer. Recently, new WHO system been proposed for classification heralding five different categories; insufficient, benign, atypical, suspicious malignancy malignant. The aim this...
Expanded endothelial gene set used for identification of compact cluster. (PDF 28Â kb)