A5035498175- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- 3D Printing in Biomedical Research
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
Lund University
2022-2024
Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response. Following our previous investigation cytological samples, the aim of this study was further explore potential impacts various clinicopathological and molecular factors...
Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared diagnostic value several immunohistochemical markers in tumors. Tissue microarrays 629 resected cancers 422 epithelial metastases various sites (whereof 275 colorectal cancer) were investigated expression CDH17, GPA33, MUC2, MUC6, SATB2, SMAD4, comparison with...
Abstract Background: Lung cancer is the most common cause of cancer-related death in Sweden with an estimated mortality 3500 persons 2021. Late diagnosis and heterogeneity disease lead to difficulty predicting optimal treatment regime for each case. Further development personalized therapy would be facilitated by reliable efficient cultivation cell samples from patients a clinical setting. A promising method grow cells as 3D structures known tumoroids, though choice extracellular matrix...
Abstract Purpose The aim of this study was to set up reliable and reproducible culture conditions for 3D tumoroids derived from non-small cell lung cancer (NSCLC) lines enable greater opportunity successful cultivation patient-derived samples. Methods Four NSCLC lines, two adenocarcinomas (A549, NCI-H1975) squamous carcinomas (HCC-95, HCC-1588), were first cultured in traditional 2D settings. Their expected expression profiles concerning TTF-1, CK7, CK5, p40 status confirmed by...