A5082180772- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cardiac tumors and thrombi
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Vascular Tumors and Angiosarcomas
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
Lund University
2014-2024
Medicon Village
2015-2024
Danderyds sjukhus
2017
Skåne University Hospital
2011-2014
Abstract Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions a major mechanism expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on patterns exist lung remains unclear. Experimental Design: Whole-genome analysis using 450K Illumina BeadArrays was performed 12 normal tissues and 124 tumors, including 83 adenocarcinomas, 23 squamous cell carcinomas (SqCC), 1 adenosquamous...
The role of imaging in the diagnosis appendicitis is controversial. This prospective interventional study and nested randomized trial analysed impact implementing a risk stratification algorithm based on Appendicitis Inflammatory Response (AIR) score, compared routine with selective after clinical reassessment.Patients presenting suspicion between September 2009 January 2012 from age 10 years were included at 21 emergency surgical centres 5 three university paediatric centres. Registration...
To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer.We evaluated 16 IHC in 209 prospectively included, surgically treated primary cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell 5 adenosquamous 2 sarcomatoid and 1 small-cell carcinoma, using the tissue microarray technique.Cytokeratin (CK5) P63 were both positive 10% or more cells 97% with former being (<10% cells) only non-squamous carcinomas. Thyroid...
A possible role for prostate cancer in Lynch syndrome has been debated based on observations of mismatch-repair defective tumors and reports an increased risk mutation carriers. Potential inclusion the tumor spectrum is relevant family classification, estimates surveillance recommendations We used population-based Danish HNPCC-register to identify all cancers that developed carriers their first-degree relatives from 288 families. The were evaluated clinicopathologic features status,...
// Anna Karlsson 1 , Hans Brunnström 2, 3 Kajsa Ericson Lindquist Karin Jirström Mats Jönsson Frida Rosengren Christel Reuterswärd Helena Cirenajwis Åke Borg 1, 6 Per 4 Maria Planck 5 Göran Johan Staaf Division of Oncology and Pathology, Department Clinical Sciences Lund, Lund University, Medicon Village, SE 22381 Sweden 2 22185 Regional Laboratories Region Skåne, Thoracic Surgery, Skåne University Hospital, Oncology, Create Health Strategic Center...
In most clinical situations involving adenovirus infection, subgenus (subgroup) identification of an isolate is as informative a finer by serotype. A PCR method which allows the human isolates members subgenera A, B:1, B:2, C, D, E, or F described. It based on simple (nonnested) using primers bind to regions immediately flanking VA RNA-encoding genomes. The amplification DNA from all 49 prototype strains so far Since there are differences in lengths adenoviruses different subgenera, it...
Abstract Background Lung cancer is the worldwide leading cause of death from cancer. Tobacco usage major pathogenic factor, but all lung cancers are not attributable to smoking. Specifically, in never-smokers has been suggested represent a distinct disease entity compared arising smokers due differences etiology, natural history and response specific treatment regimes. However, genetic aberrations that differ between never-smokers’ carcinomas remain large extent unclear. Methods Unsupervised...
Large cell lung cancer (LCLC) and large neuroendocrine carcinoma (LCNEC) constitute a small proportion of NSCLC. The WHO 2015 classification guidelines changed the definition debated histological subtype LCLC to be based on immunomarkers for adenocarcinoma squamous cancer. We sought determine whether these new also translate into transcriptional landscape cancer, specifically.Gene expression profiling was performed by using Illumina V4 HT12 microarrays (Illumina, San Diego, CA) samples from...
// Kajsa Ericson Lindquist 1, * , Anna Karlsson 2, Per Levéen 1 Hans Brunnström 3 Christel Reuterswärd 2 Karolina Holm Mats Jönsson Karin Annersten Frida Rosengren Jirström Jaroslaw Kosieradzki 4 Lars Ek Åke Borg 5 Maria Planck 6 Göran and Johan Staaf Department of Pathology, Regional Laboratories Region Skåne, Lund SE 22185, Sweden Division Oncology Clinical Sciences Lund, University, Medicon Village, 22381, Respiratory Medicine Allergology, Skane University Hospital, SE22185, CREATE Health...
Lynch syndrome confers an increased risk for urothelial carcinoma ( UC ). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have date not been defined in syndrome‐associated cancer. We aimed provide a molecular description of . Thus, s the upper urinary tract bladder were identified Danish hereditary nonpolyposis colorectal cancer HNPCC ) register transcriptionally immunohistochemically profiled further related data from 307 sporadic carcinomas. Whole‐genome...
Soft tissue sarcomas are rare, morphologically, and genetically heterogenous. Though the tumors display abundant tumor stroma with infiltrating immune cells, prognostic impact of various immunologic markers in sarcoma remains poorly defined. We aimed to characterize landscape a treatment-naïve cohort soft extremities trunk wall correlations metastasis-free survival.We surveyed immunohistochemical expression patterns for CD163, CD20, CD3, CD8, FOXP3 134 adult high-grade leiomyosarcomas,...
Abstract Lung cancer is the worldwide leading cause of death from and has been shown to be a heterogeneous disease at genomic level. To delineate landscape copy number alterations, amplifications, loss‐of‐heterozygosity (LOH), tumor ploidy copy‐neutral allelic imbalance in lung cancer, microarray‐based profiles 2,141 tumors cell lines including adenocarcinomas (AC, n = 1,206), squamous carcinomas (SqCC, 467), large ( 37) small (SCLC, 88) were assembled different repositories. Copy alteration...
Objectives Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage histopathological features. The aim of this study was to examine the association tumor markers in pre-operative serum with disease. Material methods Blood samples were collected prior 107 I-III adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 2011. Carcinoembryonic...
Introduction Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis cancer subset divided into Lynch syndrome and familial type X (FCCTX) based on presence mismatch repair (MMR) gene defects. Purpose We addressed the expression signatures in linked FCCTX with aim identify candidate genes map signaling pathways relevant carcinogenesis. Experimental design 18 k whole-genome c-DNA-mediated annealing, selection, extension, ligation (WG-DASL) assay was...
Angiosarcomas may develop as primary tumours of unknown cause or secondary tumours, most commonly following radiotherapy to the involved field. The different causative agents be linked alternate tumorigenesis, which led us investigate genetic profiles morphologically indistinguishable and angiosarcomas.Whole-genome (18k) c-DNA-mediated annealing, selection, extension ligation analysis was used genetically profile 26 29 angiosarcomas. Key findings were thereafter validated using RT-qPCR,...
Background: Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and marker measurements are easily accessible through peripheral blood could potentially identify with worse prognosis. The aim this study was to examine ctDNA in pre-operative plasma the role markers serum for their predictive potential on recurrence. Methods: Mutation analysis by 26-gene targeted sequencing performed 157 lung adenocarcinomas (ACs) from...
Abstract Accurate histological classification and identification of fusion genes represent two cornerstones clinical diagnostics in non-small cell lung cancer (NSCLC). Here, we present a NanoString gene expression platform novel platform-independent, single sample predictor (SSP) NSCLC histology for combined, simultaneous, detection minimal formalin fixed paraffin embedded (FFPE) tissue. The SSP was developed 68 tumors adenocarcinoma (AC), squamous carcinoma (SqCC) large-cell neuroendocrine...
Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define subset of cancer favorable prognosis likelihood to respond treatment anti-programmed death 1 (PD-1)/programmed ligand (PD-L1) drugs. With the aim immune-evasive mechanisms potential impact hereof in colorectal from versus hereditary cases retained repair function, we immunohistochemically...