A5037080469- Appendicitis Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Child Nutrition and Feeding Issues
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Minimally Invasive Surgical Techniques
- Meta-analysis and systematic reviews
- Congenital Diaphragmatic Hernia Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Congenital gastrointestinal and neural anomalies
- Surgical Sutures and Adhesives
- Gastroesophageal reflux and treatments
- Body Contouring and Surgery
- Electrolyte and hormonal disorders
- Hepatocellular Carcinoma Treatment and Prognosis
Karolinska Institutet
2010-2025
Karolinska University Hospital
2008-2025
University College London
2015-2020
Great Ormond Street Hospital
2015-2020
Akademiska Barnsjukhuset
2017
University of Southampton
2015
Hospital for Sick Children
2015
Boston Children's Hospital
2011
The aim of this study was to evaluate the feasibility and safety nonoperative treatment acute nonperforated appendicitis with antibiotics in children.A pilot randomized controlled trial performed comparing versus surgery for children. Patients imaging-confirmed who would normally have had emergency appendectomy were either or surgery. Follow-up 1 year.Fifty patients enrolled; 26 24 antibiotics. All children group histopathologically confirmed appendicitis, there no significant complications...
The role of imaging in the diagnosis appendicitis is controversial. This prospective interventional study and nested randomized trial analysed impact implementing a risk stratification algorithm based on Appendicitis Inflammatory Response (AIR) score, compared routine with selective after clinical reassessment.Patients presenting suspicion between September 2009 January 2012 from age 10 years were included at 21 emergency surgical centres 5 three university paediatric centres. Registration...
Objective: The aim of this study was to evaluate the safety and feasibility nonoperative treatment acute nonperforated appendicitis in children during 5 years follow-up. Methods: A 4-year follow-up a previous randomized controlled pilot trial, including 50 with appendicitis, performed. patients were initially antibiotics or appendectomy 1-year previously reported. Data extracted from computerized notes telephone interviews. primary outcome failure, defined as need for secondary intervention...
To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and finding of perforated in children.All children undergoing acute at Karolinska University Hospital, Stockholm, Sweden from 2006 to 2013 were reviewed exposure delay. Primary endpoint was histopathologic appendicitis. The main explanatory variable delay, using surgery within 12 hours as reference. Secondary endpoints postoperative wound infection, intra-abdominal abscess,...
IntroductionAcute appendicitis in children is common and the optimal treatment modality still debated, even if recent data suggest that laparoscopic surgery may result shorter postoperative length of stay without an increased number complications. The aim study was to compare outcome open appendectomies during a transition period.Materials methodsThis retrospective cohort with prospectively collected data. All patients who underwent operation for suspected at Astrid Lindgren Children's...
Abstract Purpose This study aimed to explore parents’ experience of sham feeding their baby born with esophageal atresia at home, waiting for reconstructive surgery. Method Semi-structured interviews were conducted parents six children delayed reconstruction. The analyzed using qualitative content analysis. Results Parents experienced that feed reinforced the healthy abilities in baby. They had faith own ability as care child well see baby’s strength cope difficulties. expressed health...
Objective: Several surgical approaches are being used in the reconstruction of long-gap esophageal atresia. We investigated which methods Nordic countries and postoperative complications that occurred first year life. Methods: This study is a retrospective multicenter study, where medical records on children with atresia Gross type C or D born period from 1 January 2000 to May 2017 were reviewed. Results: Forty-four patients included this forty-three one D. Thirty-six statistical analysis....
Introduction Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission a diagnostic marker perforation with AA. Materials Methods This was prospective accuracy study, including previously healthy children, 1 to 14 years age, Blood sampling included concentration, glucose, base excess, white blood cell...
The long-term incidence of acute appendicitis has been reported to be declining in Europe and North America. Recent reports, however, indicate stabilized or even increased rates. aim this study was investigate the present epidemiology appendicectomy a population-based cohort Swedish children.The National Patient Register queried for all children with and/or 1987-2013. Population-based rates were calculated. Rates age- sex-adjusted, analysed temporal regional trends.Some 56 774 identified,...
Background: The support for treatment of uncomplicated appendicitis with non-operative management as opposed to surgery has been building in the literature. We conducted a randomized trial compare failure rates.Methods: pragmatic multicenter, parallel-group, unmasked, non-inferiority, completed at 11 children's hospitals across globe. used non-inferiority design margin 20%, and 1:1 allocation while stratifying by sex, institution duration symptoms (≥ 48 hours verses <48 hours). Patients were...
This cohort study uses registry data to report the long-term outcomes of patients who participated in randomized clinical trials antibiotics vs surgery Sweden 1990s.
The optimal care for patients with unresectable, non-metastatic pancreatic adenocarcinoma (PAC) is debated. We treated 17 consecutive cases preoperative radiochemotherapy (RCT) as a means downstaging their tumours and compared outcome 35 undergoing direct surgery primarily resectable PAC during the same time period.The had biopsy proven, which engaged >or=50% of circumference patent mesenteric/portal vein distance >or=2 cm and/or <50% central artery <2 cm. preop therapy included two courses...
Fibroblast growth factor 19 (FGF19) is produced in the small intestine and involved suppression of hepatic bile acid (BA) synthesis. FGF19 also expressed liver serum levels are elevated adults with cholestatic disease. This may reflect a rescue mechanism to dampen injury caused by increased intrahepatic BAs.To examine circulating at early stages biliary atresia short-term follow-up post-Kasai portoenterostomy (KPE) relation noncholestatic infants. The relationship between FGF19, BAs markers...
Intraoperative cultures are commonly sent in complicated appendicitis. Culture-guided antibiotics used to prevent postoperative infectious complications debated. In this study, we describe the microbial overlap between intraoperative and abscess cultures, antibiotic resistance patterns.A local register of a children's hospital treating children 0-15 years old with appendicitis 2006 2013 was find cases from drained or aspirated intraabdominal abscesses. Culture results, administered...
To investigate the impact of hospital administrative level and caseload pediatric appendectomies on morbidity mortality after appendectomy in a population-based cohort Swedish children.Population-based study including all children less than 15 years age that underwent for suspected appendicitis, 1987-2009. Patient characteristics data postoperative were collected from National Register Death Register. Primary endpoints mortality. Two explanatory variables investigated: annual appendectomies....
Abstract Aim To evaluate if the incidence of postoperative complications after gastrostomy placement is correlated to perioperative parameters or patient characteristics. Methods In this prospective observational study, children <18 years age planned receive a at partaking clinics between 2014 and 2019 were invited. Pre‐, peri‐ variables collected followed up 3 months postoperatively. Results Five hundred eighty‐two patients included (median age: 26 months, median weight: 10.8 kg), mainly...