A5013412966- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
Lund University
2021-2024
Hallands sjukhus Halmstad
2017-2024
Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response. Following our previous investigation cytological samples, the aim of this study was further explore potential impacts various clinicopathological and molecular factors...
Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation immunohistochemical (IHC) analyses cytology, including surrogate markers for molecular alterations BAP1 and MTAP, interest.IHC eight different was performed 59 paired formalin-fixed, paraffin-embedded biopsies cell blocks with mesothelioma. Immunoreactivity in ≥10% tumour cells...
Abstract Background Cell blocks (CBs) are widely used for biomarker analyses such as immunostaining. Although immunohistochemistry on formalin‐fixed paraffin‐embedded tissues is standardized, there multiple preparation methods and fixatives cytology. Our objective was to investigate the effect of different common immunoreactivity pleural effusion CBs with metastatic lung adenocarcinomas. Methods This prospective study included 24 malignant effusions from patients adenocarcinoma. From each...
BACKGROUND Malignant mesothelioma (MM) is an aggressive, fatal tumor. Current therapeutic options only marginally improve survival. Programmed cell death ligand 1 (PD‐L1) a dominant mediator of immunosuppression, binding to programmed (PD‐1). PD‐L1 up‐regulated in cancer cells, and the PD‐1/PD‐L1 pathway plays critical role tumor immune evasion, thus providing target for antitumor therapy. Further, correlation between expression prognosis has been reported. Studies performed on histological...
PD-L1 expression assessed by immunohistochemical staining is used for the selection of immunotherapy in non-small cell lung cancer (NSCLC). Appropriate validation cytology specimens important as often only diagnostic material NSCLC. In a previous study comprising two different cohorts paired biopsies and cytological specimens, we found fairly good cyto-histological correlation one, whereas moderate was other cohort. Therefore, that cohort with additional new cases now further investigated...
Malignant mesothelioma (MM) is a therapy-resistant tumor, often causing an effusion. Drugs targeting the programmed cell death 1 (PD-1)/programmed ligand (PD-L1) pathway have shown promising results, but assessment of PD-L1 expression to select patients for therapy has mainly been performed on histologic tissue samples. In previous study, we showed that MM effusions are suitable with results comparable those reported in studies, no studies compared and cytologic samples.PD-L1 was determined...
Abstract Purpose The aim of this study was to set up reliable and reproducible culture conditions for 3D tumoroids derived from non-small cell lung cancer (NSCLC) lines enable greater opportunity successful cultivation patient-derived samples. Methods Four NSCLC lines, two adenocarcinomas (A549, NCI-H1975) squamous carcinomas (HCC-95, HCC-1588), were first cultured in traditional 2D settings. Their expected expression profiles concerning TTF-1, CK7, CK5, p40 status confirmed by...