A5037759399- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Occupational and environmental lung diseases
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- RNA modifications and cancer
- Estrogen and related hormone effects
- Neuroblastoma Research and Treatments
- Metastasis and carcinoma case studies
- PARP inhibition in cancer therapy
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
University of Turin
2016-2025
Ospedale San Luigi Gonzaga
2015-2025
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2024
École Polytechnique Fédérale de Lausanne
2024
Ospedale di Santo Spirito
2016
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2012
Novamont (Italy)
2012
Institute of Photonic Sciences
2012
Azienda Ospedaliero Universitaria San Giovanni Battista
2010
Ospedale Santa Chiara
2007
Lung neuroendocrine tumors are catalogued in four categories by the World Health Organization (WHO 2004) classification. Its reproducibility and prognostic efficacy was disputed. The WHO 2010 classification of digestive neoplasms is based on Ki67 proliferation assessment proved prognostically effective. This study aims at comparing these two classifications defining a grading system for lung tumors. included 399 patients who underwent surgery with least 1 year follow-up between 1989 2011....
Purpose The relationship between thymidylate synthase (TS) expression and outcome in patients with malignant pleural mesothelioma (MPM) treated pemetrexed (P) was retrospectively evaluated. Patients Methods Sixty histologically confirmed MPM previously P platinum (45 of 60) or as single agent (15 were considered. Eighty-one control not P-treated also TS excision repair cross-complementation group 1 (ERCC1) gene levels evaluated by real-time polymerase chain reaction immunohistochemistry...
Histopathological subtyping of nonsmall cell lung cancer (NSCLC) is currently relevant in treatment decision because a differential activity specific therapeutic agents. Immunohistochemistry highlights differentiation lineages and, this study, it was applied to maximize the proportion accurately subtyped NSCLC not otherwise specified (NOS) on fine-needle aspiration cytology (FNAC) samples.Cell blocks from 103 FNAC samples with morphological diagnosis NSCLC-NOS were immunostained for...
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos exposure. An inherited predisposition has been suggested to explain multiple cases in the same family and observation that not all individuals highly exposed develop tumor. Germline mutations BAP1 are responsible for rare syndrome includes mesothelioma. We hypothesized other genes involved hereditary syndromes could be predisposition. investigated prevalence of germline variants 94 cancer-predisposing 93 MPM...
Among alternative therapeutic strategies in clinically aggressive neuroendocrine tumors (NETs) of the lung, promising results have been obtained experimental clinical trials with mammalian target rapamycin (mTOR) inhibitors, though absence a proven mTOR signaling activation status. This study analyzed expression phosphorylated (p-mTOR) and its major targets, ribosomal p70S6-kinase (S6K) eukaryotic initiation factor 4E-binding protein 1 (4EBP1) large series 218 surgically resected, malignant...
Toll-like receptors (TLRs) and nucleotide-binding oligomerisation domain (NOD)-like (NLRs) are two major forms of innate immune sensors but their role in the immunopathology stable chronic obstructive pulmonary disease (COPD) is incompletely studied. Our objective here was to investigate TLR NLR signalling pathways bronchial mucosa COPD.Using immunohistochemistry, expression levels TLR2, TLR4, TLR9, NOD1, NOD2, CD14, myeloid differentiation primary response gene 88 (MyD88),...
Concern may exist that pulmonary lesions associated with cystic airspaces are at risk of increased biopsy complications or lower accuracy given challenges in targeting tissue abutting intermingled the airspaces.
Abstract Purpose: The predictive role of the quantification thymidylate synthase (TS) in tumors treated with antifolate drugs, such as 5-fluorouracil (5-FU), has been extensively reported a variety human tumors. Neuroendocrine (NET) represent potential targets agents, but no data on TS expression level these are currently available. Experimental Design: A series 116 NETs were collected, including 58 gastroenteropancreatic (GEP) and lung NETs. In 24 well-differentiated GEP neuroendocrine...
PURPOSE: In non-small cell lung cancer, higher thymidylate synthase (TS) levels have been reported in squamous carcinoma (SCC) compared with adenocarcinoma (ADC). Data on TS expression large-cell (LCC) are scanty. EXPERIMENTAL DESIGN: mRNA and protein were analyzed 42 surgical cases of pulmonary LCC, including 8 neuroendocrine carcinomas, controls represented by ADC (n = 41), SCC 30), small-cell (SCLC; n 33). also correlated the Ki67 E2F1. Moreover, reliability analysis was assessed 22...
Inherited loss‐of‐function mutations in the BAP1 oncosuppressor gene are responsible for an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and keratinocytic melanoma, other malignancies. Germline that were autosomal dominant fashion identified nine families multiplex MM cases 25 multiple renal cell carcinoma, tumors. also sporadic cases, suggesting germline occur frequently. In this article, we report analysis of five 103 MM. One family carried a new truncating...
// Emilio Bria 1,* , Sara Pilotto Eliana Amato 2 Matteo Fassan Silvia Novello 3 Umberto Peretti 1 Tiziana Vavalà Stefania Kinspergher Luisella Righi Antonio Santo Brunelli 4 Vincenzo Corbo Giglioli Isabella Sperduti 5 Michele Milella 6 Marco Chilosi Aldo Scarpa 2,4 and Giampaolo Tortora Department of Medicine, Medical Oncology, University Verona, Azienda Ospedaliera Universitaria Integrata, Italy ARC-NET Center for Applied Research on Cancer, Torino, A.O.U. San Luigi, Orbassano, Pathology...