Annika Idahl
A5023570430- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Bladder and Urothelial Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Gynecological conditions and treatments
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Uterine Myomas and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Potato Plant Research
- Birth, Development, and Health
- Nutritional Studies and Diet
- Plant Pathogens and Resistance
- Glycosylation and Glycoproteins Research
- Pelvic floor disorders treatments
- Reproductive Physiology in Livestock
Umeå University
2015-2024
University of Gothenburg
2019
Brigham and Women's Hospital
2016
National Cancer Institute
2011-2016
UPMC Hillman Cancer Center
2011
German Cancer Research Center
2011
Heidelberg University
2011
University of Pittsburgh
2011
Radiation Effects Research Foundation
2011
National Cancer Institute
2011
An understanding of the etiologic heterogeneity ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, lifestyle factors by histologic subtype in Ovarian Cancer Cohort Consortium (OC3).
Evidence suggests that the hormonal milieu of pregnancy is an important determinant subsequent cancer and other chronic diseases in both mother offspring. Many existing maternity birth cohorts include specimens drawn only once during pregnancy. How well a single blood specimen collected characterizes exposure to these hormones throughout gestation, also pregnancies, not understood. We used serial serum samples from 71 pregnant women (25 primiparous, 25 multiparous, 21 with two consecutive...
Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim this study is prospectively evaluate associations between factors risk developing intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) invasive (ICC). Methods Findings We followed a cohort 308,036 women recruited European Prospective Investigation into Cancer Nutrition (EPIC)...
It is well established that parity and use of oral contraceptives reduce the risk ovarian cancer, but associations with other reproductive variables are less clear. We examined contraceptive factors cancer in European Prospective Investigation into Cancer Nutrition. Among 327 396 eligible women, 878 developed over an average 9 years. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre age, adjusted for smoking status,...
Immature ovarian primordial follicles are essential for maintenance of the reproductive lifespan female mammals. Recently, it was found that overactivation phosphatidylinositol 3-kinase (PI3K) signaling in oocytes by an oocyte-specific deletion Pten (phosphatase and tensin homolog deleted on chromosome ten), gene encoding PI3K negative regulator PTEN, results premature activation entire pool follicles, indicating pathway is important control follicular activation. To investigate whether...
Abstract Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search early detection biomarkers. For initial testing, specimens taken months or years before cancer diagnosis the best source information evaluate Here we most promising screening biomarkers prospectively collected samples from European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We...
Abstract Background CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There a need to identify novel biomarkers, which individually or in combination with can achieve adequate sensitivity and specificity earlier-stage Methods In European Prospective Investigation into Cancer Nutrition (EPIC) cohort, we measured serum levels 92 preselected proteins 91 women who had blood sampled ≤18 months prior cancer diagnosis, 182 matched controls. We...
Abstract Background: Factors contributing to chronic inflammation appear be associated with increased risk of ovarian cancer. The purpose this study was assess the association between circulating levels mediators and subsequent Methods: We conducted a case-control 230 cases 432 individually matched controls nested within three prospective cohorts evaluate prediagnostic inflammation-related biomarkers (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα, IL-1Ra, sIL-1RII,...
Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in development cancer, we evaluated association serologic markers incident using a staged approach two independent populations. Studies included: 1) case–control study Poland (244 cancers/556 control subjects) 2) prospective nested PLCO Cancer Screening Trial (160 cancers/159 subjects). Associations marker levels risk at diagnostic as well...
Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of characteristics all-cause and cause-specific mortality risk. The analysis performed within European Investigation into Cancer Nutrition prospective cohort study, which enrolled >500,000 women men from 1992 2000, who were residing a given town/geographic area 10 countries. current included...
Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype ( i.e ., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest factor differences. We examined associations between reproductive and hormone‐related EOC in the European Prospective Investigation into Cancer Nutrition (EPIC) cohort. Among 334,126 women with on (follow‐up: 1992–2010), 1,245 incident cases known histology invasiveness were identified. Data tumor...
BACKGROUND: The objective of this study was to determine the prevalence Chlamydia trachomatis among both men and women seeking help at an infertility clinic, prospectively follow effect previous infection on pregnancy rates outcome after a long follow‐up period (mean 37 months). METHODS: A total 244 infertile couples tested for C. IgG antibodies, IgG+ were also DNA by PCR in first‐void urine sample. Study parameters serology, results, clinical diagnoses, treatments, outcome. As controls,...
Abstract Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor‐α (TNF‐α), one of the major pro‐inflammatory cytokines, also implicated physiology. We conducted case‐control study nested within European prospective investigation into and nutrition (EPIC) examine association TNF‐α its two soluble receptors (sTNFR1 sTNFR2) with risk. Two‐hundred‐seventy cases 518 matched controls were analyzed using conditional logistic regression....
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in carcinogenesis risk factor differences by histologic phenotypes developmental pathways. Research on prediagnosis androgen concentrations has yielded inconclusive results, analyses incorporating subtypes are sparse. We conducted pooled analysis 7 nested case-control studies Ovarian...
Abstract Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes anthropometric indices. Prospective studies on circulating inflammatory markers epithelial invasive cancer (EOC) have predominantly investigated overall risk; data characterizing risk by characteristics (histology, grade, stage, dualistic model of carcinogenesis) indices are sparse. Methods: We conducted a nested case–control study the European...
Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between circulating marker inflammation, C-reactive protein (CRP), and cancer risk has been consistently observed, yet, potential heterogeneity this by tumor patient characteristics not adequately explored. In study, we pooled data from case-control studies nested within six cohorts in the Ovarian Cancer Cohort Consortium (OC3) to examine CRP epithelial overall, histologic...
Repeated exposure to the acute proinflammatory environment that follows ovulation at ovarian surface and distal fallopian tube over a woman's reproductive years may increase cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used estimate...
Epithelial ovarian cancer is an insidious disease, and women are often diagnosed when the disease beyond curative treatment. Accordingly, identifying modifiable risk factors of paramount importance. Inflammation predisposes individual to in various organs, but whether pelvic inflammatory associated with increased epithelial has not been fully determined.
Objective . To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods Plasma samples from 291 women, undergoing surgery due to suspected pathology, were analyzed respect C. IgG IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) M. antibodies. Women borderline tumors (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:mrow></mml:math>), carcinoma...
Abstract New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose this study was examine different measures exposures subtypes EOC in large cohort women from 10 European countries. Prospective Investigation into Cancer Nutrition (EPIC) is multicenter prospective initiated 1992. questionnaires included about dietary, lifestyle, health factors. Information cigarette collected...
Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased who may benefit from targeted prevention measures, such as screening or chemopreventive agents. We built an ovarian model with epidemiologic factors 202 206 in the European Prospective Investigation into Cancer and Nutrition study. Older age menopause, longer duration of hormone replacement therapy, higher body mass index were included...
The role of endogenous androgens and sex hormone-binding globulin (SHBG) in ovarian carcinogenesis is poorly understood. Epithelial invasive cancer (EOC) a heterogeneous disease there are no prospective data on EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model (i.e. type I vs. II, leading to less more aggressive tumors). We conducted nested case-control study European Prospective Investigation into Cancer Nutrition (EPIC) cohort evaluating SHBG...
Abstract Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a “nutrient-wide association study” approach to systematically evaluate risk associations for while controlling multiple hypothesis tests using false discovery rate (FDR) validating results an independent cohort. evaluated intake 84 foods nutrients based questionnaires three prospective studies, European Prospective Investigation into Cancer Nutrition (EPIC; N = 1,303...