A5068681667- Genetic Associations and Epidemiology
- Botanical Research and Chemistry
- Ethnobotanical and Medicinal Plants Studies
- Diabetes and associated disorders
- Diabetes Treatment and Management
- RNA modifications and cancer
- Forensic and Genetic Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetic and phenotypic traits in livestock
- Fatty Acid Research and Health
- BRCA gene mutations in cancer
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Animal Nutrition and Physiology
- Plant Pathogens and Fungal Diseases
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Stress Responses and Cortisol
- Venous Thromboembolism Diagnosis and Management
- Genomics and Rare Diseases
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- Telomeres, Telomerase, and Senescence
Lovely Professional University
2024
Shri Mata Vaishno Devi University
2014-2023
MedStar Georgetown University Hospital
2023
Georgetown University
2023
Indian Council of Agricultural Research
2022
Pennsylvania State University
2020
Program for Appropriate Technology in Health
2018
Rice University
2012
International Atomic Energy Agency
2012
Council of Scientific and Industrial Research
2011
Kombucha is a popular fermented tea that has attracted considerable attention due, in part, to its suggested health benefits. Previous results from animal models led us hypothesize kombucha may reduce blood sugar levels humans with diabetes. The objective of this pilot clinical study was evaluate for anti-hyperglycemic activities adults diabetes mellitus type II.The organized as prospective randomized double-blinded crossover at single-center urban hospital system. Participants (n = 12) were...
The use of bioactive compounds and probiotic bacteria against the viral diseases in human is known for a long time. Anti-viral, anti-inflammatory anti-allergic properties with respiratory may have significance to enhance immunity. This review highlights some important bacteria, suggesting them as ray hope milieu COVID-19 management.
Abstract Rising cases of type 2 diabetes (T2D) in India, especially metropolitan cities is an increasing concern. The individuals that were most affected are young professionals working the corporate sector. However, sector has remained least explored for T2D risk predisposition. Considering employees’ lifestyles and role gene-environment interaction susceptibility, study aims to find genetic variants associated with In this first kind study, 680 (284 cases, 396 controls) diagnosed screened...
Objectives: The objective of the study was to ascertain adverse events (major cardiac and limb events) in patients established peripheral arterial disease (PAD), on clopidogrel aspirin antiplatelet therapy. Patients Methods: aged 18 years or over, with PAD were screened for participation study. considered have symptomatic if they met either two criteria: a history intermittent claudication, rest pain, tissue loss presumed atherosclerotic origin, ankle–brachial index <0.85, previous leg...
Abstract Background Varicose veins (VV) are spectrum of common vascular diseases having complex genetic etiology. The Castor Zinc Finger 1 ( CASZ1 ) gene has been involved in development and its variant shown association with VV various ethnicities, but susceptibility to risk is unexplored the South Asian Indian population. objective this study was estimate variations Indians, examine evolutionary patterns these variants compared other populations. Methodology Population based case control...
In the present study, we provide a checklist of vascular plants Kinnaur district situated in Himachal Pradesh state India western Himalaya. This includes 893 taxa (viz., species, subspecies and varieties) belonging to 881 species angiosperms gymnosperms distributed among 102 families 433 genera, 30 pteridophytes. Information about growth habit, threat endemicity status is also provided. Our results show that family Compositae by far most rich with 122 followed Poaceae (69), Rosaceae (58),...
Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups present-day populations of Europe. While most subclades are older than 30 thousand years, comparatively recent coalescence time extant variation U7 (~16–19 years ago) suggests its current distribution consequence more dispersal events, despite wide geographical range across...
Abstract Jammu and Kashmir (J&K), the Northern most State of India, has been under-represented or altogether absent in phylogenetic studies carried out literature, despite its strategic location Himalayan region. Nonetheless, this region may have acted as a corridor to various migrations from mainland Eurasia northeast Asia. The belief goes that post-late-Pleistocene were mainly male dominated, primarily associated with population invasions, where female migration thus limited. To...
Adverse effects of antileishmanial drugs can affect patients' quality life and adherence to therapy for visceral leishmaniasis (VL) post-kala-azar dermal (PKDL). In Bangladesh, there are 26 treatment centers that manage cases coming from 100 endemic upazilas (subdistricts) districts (these include VL, PKDL, failure, relapse VL cutaneous cases). This study aimed investigate the feasibility using focused pharmacovigilance (VLPV) in Bangladesh's National Kala-azar Elimination Programme early...
Abstract Buckwheat ( Fagopyrum spp.) is an important nutritional and nutraceutical‐rich pseudo‐cereal crop. Despite its obvious potential as a functional food, buckwheat has not been fully harnessed due to low yield, self‐incompatibility, increased seed cracking, limited set, lodging, frost susceptibility. The inadequate availability of genomics resources in one the major reasons for this. In present study, genome‐wide association mapping (GWAS) was conducted identify loci associated with...
Acute myeloid leukemia is a heterogeneous disease with 5-year survival rate of 28.3%, and current treatment options constrained by dose-limiting toxicities. One the key signaling pathways known to be frequently activated dysregulated in AML PI3K/AKT signaling. Its dysregulation associated aggressive cell growth drug resistance. We investigated activity Phenybutyl isoselenocyanate (ISC-4) primary cells obtained from newly diagnosed patients, diverse lines, normal cord blood cells. ISC-4...
Abstract Telomere length attrition has been implicated in various complex disorders including Type 2 Diabetes (T2D). However, very few candidate gene association studies have carried out worldwide targeting telomere maintenance genes. In the present study, variants critical pathway genes for T2D susceptibility Northwest Indian population were explored. With case-control study design, twelve from seven evaluated. Amongst these five variants, rs9419958 ( OBFC1 ), rs4783704 TERF2 rs16847897...
Narrow genetic base, complex allo-tetraploid genome and presence of repetitive elements have led the discovery single nucleotide polymorphisms (SNPs) in Brassica juncea (AABB; 2n = 4x 36) at a slower pace. Double digest RAD (ddRAD) - complexity reduction technique followed by NGS was used to generate total 23 million paired-end reads from three genotypes each Indian (Pusa Tarak, RSPR-01 Urvashi) Exotic (Donskaja IV, Zem 1 EC287711) genepools.Sequence data analysis identification 10,399 SNPs...
Abstract Background MassARRAY (Agena Bioscience™) combines competitive PCR with MALDI-TOF mass spectrometry (MS) analysis that gives highly accurate, sensitive, and high-throughput methods for the quantitative of variation gene expression in multiple samples. SNPs (Single Nucleotide Polymorphisms) have a very high potential discovering disease-gene relationships. SNP-genotyping through is not only cost-effective genotyping method but also provides platform to validate variants observed...
Abstract Background Varicose vein is a chronic condition that affects the lower extremities of human body. Several factors have been implicated in development this disease, viz age, gender, weight, height and prolonged standing. Recently, genome-wide studies identified genetic biomarkers are associated with varicose veins different ethnic groups. Such lacking South Asians specifically Indians where prevalence high, it important to replicate these variants stated population. The study aimed...