A5006948265- Forensic and Genetic Research
- Yersinia bacterium, plague, ectoparasites research
- Agriculture and Biological Studies
- Archaeology and ancient environmental studies
- Genetic diversity and population structure
- Eurasian Exchange Networks
- Cancer-related molecular mechanisms research
- Identification and Quantification in Food
- Animal Diversity and Health Studies
- Human Health and Disease
- Climate Change and Health Impacts
- Soviet and Russian History
- Digestive system and related health
- BRCA gene mutations in cancer
- High Altitude and Hypoxia
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Social and Behavioral Studies
- Cell Adhesion Molecules Research
- Ancient and Medieval Archaeology Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Esophageal and GI Pathology
- Travel-related health issues
- interferon and immune responses
Ufa Institute of Chemistry
2019-2025
Korea University of Science and Technology
2024-2025
University of Science and Technology
2024-2025
Russian Academy of Sciences
2017-2024
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2017-2023
Bashkir State University
2016-2022
Estonian Biocentre
2017
In recent years, statistical studies show that cholelithiasis is detected in every fifth woman and tenth man. Сholelithiasis a multifactorial process influenced by both environmental genetic factors. Some evidence suggests total plasma homocysteine correlates with the presence of gallstones, suggesting hyperhomocysteinemia risk factor for cholelithiasis. The aim this work was to analyze association polymorphic variants methylenetetrahydrofolate reductase MTHFR (rs1801133 (677C>T),...
Background and objective — Gastric cancer (GC) is one of the most common cancers worldwide with a high mortality rate. Hereditary predisposition to GC still not fully understood. The this study was compare prevalence mutations in BRCA1 (c.68_69delAG, c.4035delA, c.5266dupC, c.3700_3704delGTAAA, c.3756_3759delGTCT, c.181T>G, c.1961delA), BRCA2 (c.5946delT), CHEK2 (c.1100delC, c.115+1G>A) NBS1 (c.657_661delGTTTT) genes patients healthy donors from Volga-Ural region Russia. Methods...
Abstract Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups present-day populations of Europe. While most subclades are older than 30 thousand years, comparatively recent coalescence time extant variation U7 (~16–19 years ago) suggests its current distribution consequence more dispersal events, despite wide geographical range across...
The human serine protease 2 TMPRSS2 is involved in the priming of proteins severe acute respiratory syndrome coronavirus (SARS-CoV-2) and represents a possible target for COVID-19 therapy. gene may be co-expressed with SARS-CoV-2 cell receptor genes angiotensin-converting enzyme (ACE2) Basigin (BSG), but only demonstrates tissue-specific expression alveolar cells according to single-cell RNA sequencing data. Our analysis structural variability based on genome-wide data from 76 populations...
Abstract We set out to identify the origins of Árpád Dynasty based on genome sequencing DNA derived from skeletal remains Hungarian King Béla III (1172–1196) and eight additional individuals (six males, two females) originally interred at Royal Basilica Székesfehérvár. Y-chromosome analysis established that individuals, HU52 assign haplogroups R-Z2125 whose distribution centres near South Central Asia with subsidiary expansions in regions modern Iran, Volga Ural region Caucasus. Out a cohort...
Abstract Medieval era encounters of nomadic groups the Eurasian Steppe and largely sedentary East Europeans had a variety demographic cultural consequences. Amongst these outcomes was emergence Lipka Tatars—a Slavic-speaking Sunni-Muslim minority residing in modern Belarus, Lithuania Poland, whose ancestors arrived territories via several migration waves, mainly from Golden Horde. Our results show that Belarusian Tatars share substantial part their gene pool with as indicated by...
Gastric cancer (GC) is one of the most common types in world with a high mortality rate. Hereditary predisposition for GC not fully elucidated so far. The aim this study was identification possible new candidate genes, associated increased risk gastric development. Whole exome sequencing (WES) performed on 18 DNA samples from adenocarcinoma specimens and non-tumor-bearing healthy stomach tissue same patient. Three pathogenic variants were identified: c.1320+1G>A CDH1 gene...
Abstract The human serine protease TMPRSS2 gene is involved in the priming of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins being one possible targets for COVID-19 therapy. possibly co-expressed with SARS-CoV-2 cell receptor genes ACE2 and BSG, but only demonstrates tissue-specific expression alveolar cells according to single RNA sequencing data. Our analysis structural variability based on genome-wide data 76 populations that functionally significant missense...
The work examines the main mechanisms responsible for process of acclimatization population high mountain regions to conditions hypobaric hypoxia. purpose this review is describe pathways genetic, epigenetic and physiological control in adaptation indigenous populations highlands reduced barometric pressure oxygen tension environment. It has been shown that living different high-mountain demonstrate ways response a decrease partial inspired air. changes occur body stressful are extremely...
Introduction. The geographical feature of the Volga-Ural region is its location on border Europe and Asia, which, together with proximity to Caspian steppes, Ciscaucasia Siberia, facilitated as formation many migration trade routes connecting these regions in different historical periods, which turn affected ethnogenesis peoples region. Genetic features underlying inheritance human pigmentation are subject active study by molecular population geneticists. Goals. work aims distribution...
Gastric cancer (GC) is one of the most serious diseases, occupying a leading position among causes death from malignant neoplasms in world. The Republic Bashkortostan (RB) also has high rates morbidity and mortality due to stomach. One main genes that determine risk predisposition this pathology CDH1 gene. aim study: Search for changes nucleotide sequence gene patients with gastric Bashkortostan. Materials methods: material study was DNA samples healthy donors living RB. Genomic isolated...
The Early Iron Age nomadic Scythians have been described as a confederation of tribes different origins, based on ancient DNA evidence. It is still unclear how much the Scythian dominance in Eurasian Steppe was due to movements people and reflected cultural diffusion elite dominance. We present new whole-genome sequences 31 Western Eastern individuals including well samples pre- postdating them, allowing us set temporal context (in Western/Ponto-Caspian Steppe). detect an increase eastern...
Анализ геномных данных (~ 907 750 аутосомных SNP) позволил оценить уровень инбридинга на основе идентификации регионов высокой гомозиготности (FROH) в выборке из 518 человек 23 коренных народов Дагестана. В результате, популяциях коренного населения Дагестана количество и суммарная длина ROH, а также коэффициент FROH показывают значительное разнообразие как внутри, так между исследованными популяциями. У гинухцев, гунзибцев, ахвахцев, бежтинцев цезов наблюдаются одни самых высоких значений...
Выявлен вклад тюркского по происхождению компонента в генофонд различных этносов Дагестана и Северного Кавказа, который присутствует не только у тюркоязычных популяций, но соседних с ними. В горных популяциях Дагестана, отличие от равнинных, тюркский компонент практически полностью отсутствует. The contribution of Turkic genetic component to the gene pool various ethnic groups Dagestan and North Caucasus, which is present not only in Turkic-speaking populations, but also neighboring ones,...
Выявлен вклад монгольского по происхождению компонента в генофонд различных этносов Сибири, Средней Азии и Волго-Уральского региона, который присутствует у монголоязычных тюркоязычных этносов. Анализ состава сублиний гаплогрупп Y-хромосомы показывает, что привнесение этого генетического было связано с различными времени миграционными событиями разными родоплеменными группами. The contribution of the Mongolian component to gene pool various ethnic groups Siberia, Central Asia and Volga-Ural...
Malignant neoplasms of the ovaries are one most frequently diagnosed tumors female reproductive system and leading causes cancer death in women worldwide. Despite significant advances field early diagnosis treatment disease, survival rate patients with this form oncopathology is still low, which dictates need for further study problem. The aim work was to evaluate role polymorphic variants rs13181 rs238406 ERCC2 gene development hereditary sporadic forms ovarian different ethnicity from...
Сахарный диабет 2 типа является многофакторным заболеванием.Развитие данного заболевания связано со сложным взаимодействием различных генов и факторов окружающей среды