Darya Prokofyeva
A5073868340- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Gene expression and cancer classification
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- HER2/EGFR in Cancer Research
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Gallbladder and Bile Duct Disorders
- Climate Change and Health Impacts
- Esophageal and GI Pathology
- Travel-related health issues
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- High Altitude and Hypoxia
University of Science and Technology
2024-2025
Korea University of Science and Technology
2024-2025
Ufa Institute of Chemistry
2023-2025
Bashkir State University
2016-2024
University of Manchester
2021
St Mary's Hospital
2021
Edinburgh Cancer Research
2021
Cancer Research Center
2021
Bashkir State Medical University
2019-2020
Institute of Biochemistry and Genetics of Ufa Scientific Centre
2012-2014
In recent years, statistical studies show that cholelithiasis is detected in every fifth woman and tenth man. Сholelithiasis a multifactorial process influenced by both environmental genetic factors. Some evidence suggests total plasma homocysteine correlates with the presence of gallstones, suggesting hyperhomocysteinemia risk factor for cholelithiasis. The aim this work was to analyze association polymorphic variants methylenetetrahydrofolate reductase MTHFR (rs1801133 (677C>T),...
Background . The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search new molecular genetic markers. aim study was analyze association rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA polymorphic variants with risk developing in women from Republic Bashkortostan. Material methods Our research included DNA samples (n=205) without at time blood sampling (n=259) Genotyping carried out using Real Time PCR...
Background and objective — Gastric cancer (GC) is one of the most common cancers worldwide with a high mortality rate. Hereditary predisposition to GC still not fully understood. The this study was compare prevalence mutations in BRCA1 (c.68_69delAG, c.4035delA, c.5266dupC, c.3700_3704delGTAAA, c.3756_3759delGTCT, c.181T>G, c.1961delA), BRCA2 (c.5946delT), CHEK2 (c.1100delC, c.115+1G>A) NBS1 (c.657_661delGTTTT) genes patients healthy donors from Volga-Ural region Russia. Methods...
Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).To further investigate the rs865686-breast association, we conducted replication within Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls).This provides additional strong evidence of an inverse between rs865686 and risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 × 10(-29)]...
Gastric cancer (GC) is one of the most common types in world with a high mortality rate. Hereditary predisposition for GC not fully elucidated so far. The aim this study was identification possible new candidate genes, associated increased risk gastric development. Whole exome sequencing (WES) performed on 18 DNA samples from adenocarcinoma specimens and non-tumor-bearing healthy stomach tissue same patient. Three pathogenic variants were identified: c.1320+1G>A CDH1 gene...
CDK12 is a member of the cyclin-dependent kinase family that acts as regulator DNA damage response gene expression. A c.1047-2A>G splice site variant was recently reported to strongly associate with hereditary breast and ovarian cancer in patients Tatar ethnic origin. To gain more insight into potential risk population spread variant, we have genotyped three case-control series Tatar, Bashkir Kazakh ethnicity. We identified 6/155 cases 12/362 controls ancestry, 0/96 9/189 1/131 0/154...
The work examines the main mechanisms responsible for process of acclimatization population high mountain regions to conditions hypobaric hypoxia. purpose this review is describe pathways genetic, epigenetic and physiological control in adaptation indigenous populations highlands reduced barometric pressure oxygen tension environment. It has been shown that living different high-mountain demonstrate ways response a decrease partial inspired air. changes occur body stressful are extremely...
Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used COVID-19 treatment. p450 genes are linked to pathogenesis some multifactorial traits diseases, such as cancer, particularly prostate colorectal breast cervical cancer. Genotyping was performed on 540 supposedly healthy individuals 5 Finno-Permic populations from territories European part Russian Federation. There a statistically significant difference...
<div>Abstract<p><b>Background:</b> Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).</p><p><b>Methods:</b> To further investigate the rs865686–breast association, we conducted replication within Breast Cancer Association Consortium, which comprises 37 case–control studies (48,394 cases, 50,836 controls).</p><p><b>Results:</b> This provides additional...
<div>Abstract<p><b>Background:</b> Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).</p><p><b>Methods:</b> To further investigate the rs865686–breast association, we conducted replication within Breast Cancer Association Consortium, which comprises 37 case–control studies (48,394 cases, 50,836 controls).</p><p><b>Results:</b> This provides additional...