A5011243448- Forensic and Genetic Research
- Genetic diversity and population structure
- Race, Genetics, and Society
- Forensic Anthropology and Bioarchaeology Studies
- Genetic Associations and Epidemiology
- Hemoglobinopathies and Related Disorders
- Research Data Management Practices
- Molecular Biology Techniques and Applications
- Ethics in Clinical Research
- Genetic and phenotypic traits in livestock
- Microfluidic and Capillary Electrophoresis Applications
- Neonatal Health and Biochemistry
- Scientific Computing and Data Management
- Malaria Research and Control
- Erythrocyte Function and Pathophysiology
- Paleopathology and ancient diseases
- Yersinia bacterium, plague, ectoparasites research
- Genetic Mapping and Diversity in Plants and Animals
- Metabolism and Genetic Disorders
- Indigenous Studies and Ecology
- Biomedical Ethics and Regulation
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- Rangeland Management and Livestock Ecology
- Glycosylation and Glycoproteins Research
Sapienza University of Rome
2013-2024
Istituto Italiano per l'Africa e l'Oriente
2013-2017
Università Cattolica del Sacro Cuore
1986-2012
Universidade do Porto
2008
University of Bologna
2008
University of Chicago
1999
Universidade Federal do Paraná
1999
University of Padua
1998
Catholic University of America
1994
The frequencies of low-activity alleles glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence malaria. These “deficiency” thought to provide reduced risk from infection by Plasmodium parasite and maintained at high frequency despite hemopathologies that they cause. Haplotype analysis “A−” ”Med“ mutations this locus indicates have evolved independently increased a rate is too rapid be explained random genetic drift. Statistical modeling A− allele arose within...
Many studies of human populations have used the male-specific region Y chromosome (MSY) as a marker, but MSY sequence variants traditionally been subject to ascertainment bias. Also, dating haplogroups has relied on Y-specific short tandem repeats (STRs), involving problems mutation rate choice, and possible long-term saturation. Next-generation sequencing can ascertain single nucleotide polymorphisms (SNPs) in an unbiased way, leading phylogenies which branch-lengths are proportional time,...
Sub-Saharan Africa has consistently been shown to be the most genetically diverse region in world. Despite fact that a substantial portion of this variation is partitioned between groups practicing variety subsistence strategies and speaking languages, there currently no consensus on genetic relationships sub-Saharan African populations. San (a subgroup KhoeSan) many Pygmy maintain hunter-gatherer lifestyles cluster together autosomal-based analysis, whereas non-Pygmy Niger-Kordofanian...
Comparisons between archaeological findings and allele frequencies at protein loci suggest that most genes of current Europeans descend from populations have been expanding in Europe the last 10,000 years, Neolithic period. Recent mitochondrial data interpreted as indicating a much older, Paleolithic ancestry. In spatial autocorrelation study seven hypervariable (four microsatellites, two larger, tandem-repeat loci, sequence polymorphism) broad clinal patterns DNA variation were recognized....
In this paper, we present a study of genetic variation in sub-Saharan Africa, which is based on published and unpublished data fast-evolving (hypervariable region 1 mitochondrial DNA six microsatellites Y chromosome) slow-evolving (haplogroup frequencies) polymorphisms mtDNA chromosome. Our reveals striking difference the structure food-producer (Bantu Sudanic speakers) hunter-gatherer populations (Pygmies, Kung, Hadza). fact, ratio to Y-chromosome Nupsilon substantially higher food...
Variation at the UDP-glucuronosyltransferase (UGT) 1A1 gene promoter is present in humans. Variable numbers of TA repeats TATA box this are found which inversely related to levels expression. We investigated polymorphism 658 individuals from a worldwide sample 15 aboriginal and two admixed human populations. This study shows that there great deal variability across ethnic groups with regard UGT1A1 allele frequencies, most common varying frequency 33% 91%. Populations African origin harbor...
Pygmy populations are among the few hunter-gatherers currently living in sub-Saharan Africa and mainly represented by two groups, Eastern Western, according to their current geographical distribution. They scattered across Central African belt surrounded Bantu-speaking farmers, with whom they have complex social economic interactions. To investigate demographic history of a population approach was applied analysis 205 complete mitochondrial DNA (mtDNA) sequences from ten central populations....
Abstract We estimate parameters of a general isolation-with-migration model using resequence data from mitochondrial DNA (mtDNA), the Y chromosome, and two loci on X chromosome in samples 25–50 individuals each 10 human populations. Application coalescent-based Markov chain Monte Carlo technique allows simultaneous inference divergence times, rates gene flow, as well changes effective population size. Results comparisons between sub-Saharan African Eurasian populations that 1500 founded...
This study analyzes data sharing regarding mitochondrial, Y chromosomal and autosomal polymorphisms in a total of 162 papers on ancient human DNA published between 1988 2013. The estimated rate was not far from totality (97.6% ± 2.1%) substantially higher than observed other fields genetic research (evolutionary, medical forensic genetics). Both questionnaire-based survey the examination Journals' editorial policies suggest that this high cannot be simply explained by need to comply with...
The study of Y chromosome variation has helped reconstruct demographic events associated with the spread languages, agriculture, and pastoralism in sub-Saharan Africa, but little attention been given to early history continent. In order overcome this lack knowledge, we carried out a phylogeographic analysis haplogroups A B broad data set populations. These two lineages are particularly suitable for objective because they most deeply rooted branches genealogy. Their distribution is almost...
The characterization of the structure southern African populations has been subject numerous genetic, medical, linguistic, archaeological, and anthropological investigations. Current diversity in subcontinent is result complex events genetic admixture cultural contact between early inhabitants migrants that arrived region over last 2000 years. Here, we analyze 1856 individuals from 91 populations, comprising novel published genotype data, to characterize ancestry profiles 631 51 populations....
The animal and plant biodiversity of the Italian territory is known to be one richest in Mediterranean basin Europe as a whole, but does genetic diversity extant human populations show comparable pattern? According number studies, structure retains signatures complex peopling processes which took place from Paleolithic modern era. Although observed patterns highlight remarkable degree heterogeneity, they do not, however, take into account an important source variation. In fact, Italy home...
The Eastern Pygmies from Zaire and Western Cameroon, Congo, the Central African Republic represent two principal groups of Pygmies. In "recent divergence" hypothesis in which are thought to be result hybridization between ancestors Bantu farmers who penetrated equatorial belt came into contact with around 2–3 kiloyears ago. On basis recent archaeological research tropical rain forest, we propose a "pre‐Bantu hypothesis, posits separation earlier than 18 order test hypotheses, analyzed...
The current distribution of Bantu languages is commonly considered to be a consequence relatively recent population expansion (3-5kya) in Central Western Africa. While there substantial consensus regarding the centre origin (the Benue River Valley, between South East Nigeria and Cameroon), identification area from where actually started, relation processes leading spread peoples relevance local migratory events remain controversial. In order shed new light on these aspects, we studied Y...
The achievement of a robust, effective and responsible form data sharing is currently regarded as priority for biological bio-medical research. Empirical evaluations may be an indispensable first step in the identification critical aspects development strategies aimed at increasing availability research scientific community whole. Research concerning human genetic variation represents potential forerunner establishment widespread primary datasets. However, no specific analysis has been...