A5010265765- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Archaeology and ancient environmental studies
- Paleopathology and ancient diseases
- Genetic diversity and population structure
- Yersinia bacterium, plague, ectoparasites research
- Isotope Analysis in Ecology
- Race, Genetics, and Society
- Pleistocene-Era Hominins and Archaeology
- Pacific and Southeast Asian Studies
- Genomics and Phylogenetic Studies
- Archaeological and Geological Studies
- Genetic Associations and Epidemiology
- Celiac Disease Research and Management
- Molecular Biology Techniques and Applications
- dental development and anomalies
- Archaeological and Historical Studies
- Agricultural and Food Production Studies
- Ancient Mediterranean Archaeology and History
- Language and cultural evolution
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Identification and Quantification in Food
University of Rome Tor Vergata
2015-2024
École Française de Rome
2019
Université de Pau et des Pays de l'Adour
2019
Institut de Biologia Evolutiva
2019
United States Nuclear Regulatory Commission
2014
Institute of Molecular Biology and Pathology
2004
Universidad Complutense de Madrid
1996-1999
Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about intial colonization remain unclear. To investigate pioneering phase in we analyzed total 623 complete mtDNAs and Asia, including 20 new seven Asia. This sequence data was used direct high-resolution genotyping American 26 populations. Here describe more genetic diversity within founder population than previously reported. The newly resolved...
Abstract Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . Here, to investigate cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from Mesolithic and Neolithic periods—from across northern western Eurasia. These were imputed alongside published data obtain diploid genotypes more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending Black Sea Baltic. hunter-gatherers highly...
Abstract Mitochondrial and Y‐chromosome DNA were analyzed from 10,300‐year‐old human remains excavated On Your Knees Cave on Prince of Wales Island, Alaska (Site 49‐PET‐408). This individual's mitochondrial (mtDNA) represents the founder haplotype an additional subhaplogroup haplogroup D that was brought to Americas, demonstrating widely held assumptions about genetic composition earliest Americans are incorrect. The amount diversity has accumulated in over past 10,300 years suggests...
Abstract Here we report on a stable isotope palaeodietary study of Imperial Roman population interred near the port Velia in Southern Italy during 1st and 2nd centuries AD. Carbon nitrogen analyses were performed collagen extracted from 117 adult humans as well range fauna to reconstruct individual dietary histories. For majority individuals, found that data consistent with diet high cereals, relatively modest contributions meat only minor marine fish. However, substantial isotopic variation...
Summary Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . To investigate cross-continental impacts we shotgun-sequenced 317 primarily Mesolithic and Neolithic genomes from across Northern Eurasia. These were imputed alongside published data to obtain diploid genotypes >1,600 ancient humans. Our analyses revealed a ‘Great Divide’ genomic boundary extending Black Sea Baltic. hunter-gatherers (HGs) highly genetically differentiated east west of this...
Huntington's disease is caused by a pathologically long (>35) CAG repeat located in the first exon of Huntingtin gene (HTT). While expanded repeats are focus extensive investigations, non-pathogenic tracts protein-coding genes less well characterized. Here, we investigated function and evolution physiological tract HTT gene. We show that poly-glutamine (polyQ) encoded CAGs huntingtin protein (HTT) under purifying selection subjected to stronger selective pressures than CAG-encoded polyQ...
Human apolipoprotein E is the most important supplier of cholesterol precursor for steroid hormone production in steroidogenic tissues and therefore could play a role regulation function influence human reproduction. This hypothesis has been confirmed by studies describing differential fertility associated with common (APOE) genotypes two European populations. In present investigation impact APOE genetic variation on was studied Ecuadorian populations, African-Ecuadorians (57 women) Cayapa...
The Tuareg of the Fezzan region (Libya) are characterized by an extremely high frequency (61%) haplogroup H1, a mitochondrial DNA (mtDNA) that is common in all Western European populations. To define how and when H1 spread from Europe to North Africa up Central Sahara, Fezzan, we investigated complete genomes eleven Libyan belonging H1. Coalescence time estimates suggest arrival mtDNAs at about 8,000–9,000 years ago, while phylogenetic analyses reveal three novel branches, termed H1v, H1w...
Abstract Stable isotope analysis of human remains has been used to address long‐standing debates regarding the speed and degree which introduction farming transformed diet. In Europe, this debate centered on northern Atlantic regions with much less attention devoted arrival across Mediterranean. This study presents carbon nitrogen stable analyses collagen from 19 37 faunal eight sites in Apulia Marche south‐eastern central Italy, dating early phases agricultural adoption during first half...
Stable isotope analysis in the reconstruction of human palaeodiets can yield clues to early subsistence strategies, origins and history farming pastoralist societies, intra- intergroup social differentiation. In last 10 years, method has been extended pathological investigation. better understand a diet-related disease: celiac disease ancient bones was carried out. To do this, we analyzed nitrogen carbon isotopic composition (n = 37) faunal 8) bone remains from archaeological site Cosa at...
A multidisciplinary approach, combining stable isotope analysis from bone proteins and investigations on dental calculus using DNA analysis, light microscopy, gas chromatography coupled with mass spectrometry, was applied to reconstruct dietary medicinal habits of the individuals recovered in cemetery Castle Santa Severa (7th-15th centuries CE; Rome, Italy). Stable performed 120 humans, 41 faunal specimens 8 charred seeds. Dental analyses were carried out 94 samples. Overall, data indicated...
Abstract Recent improvements in the analysis of ancient biomolecules from human remains and associated dental calculus have provided new insights into prehistoric diet genetic diversity our species. Here we present a multi-omics study, integrating metagenomic proteomic analyses calculus, DNA petrous bones two post-Last Glacial Maximum (LGM) individuals San Teodoro cave (Italy), to reconstruct their lifestyle post-LGM resettlement Europe. Our show homogeneity Sicily during Palaeolithic,...
The estrogen receptor (ER) plays an important role in mediating action on target tissues. ER-alpha, the most abundant, is found all human reproductive tissues and studies alpha-ER knockout mice have highlighted its reproduction. ER-alpha gene (ESR1) polymorphisms been associated with a variety of disorders including infertility. In this study, we examined association ESR1 PvuII XbaI fertility two populations different patterns precisely sample healthy Italian men women (n = 178)...
AbstractBackground: Coeliac disease (CD) is characterized by increased immunological responsiveness to ingested gliadin in genetically predisposed individuals. This genetic predisposition not completely defined. A dysregulation of immunoglobulins (Ig) present CD: since antiendomysium antibodies (anti-EMA) are the IgA class. One polymorphic enhancer within locus control region (LCR) immunoglobulin heavy chain cluster at 3′ C alpha-1 gene was investigated. The correlation penetrance four...
The Early Neolithic involved an important social and economic shift that can be tested not only with the material culture, but also through biomolecular approaches. Iberian Peninsula presents few sites where fauna humans analyzed together from isotopic perspective. Here we present study on site of Cueva de Chaves as example for understanding dietary economical changes took place during in Iberia.Here apply carbon nitrogen stable isotope analysis to bone collagen 4 64 faunal samples 14...
A pioneer study on burned archaeological bones, by physicochemical techniques, provided unique information past civilizations.