Francesca Brisighelli
A5063305391- Forensic and Genetic Research
- Genetic diversity and population structure
- Race, Genetics, and Society
- Forensic Anthropology and Bioarchaeology Studies
- Yersinia bacterium, plague, ectoparasites research
- Molecular Biology Techniques and Applications
- Archaeology and ancient environmental studies
- Genetic Associations and Epidemiology
- Identification and Quantification in Food
- Pleistocene-Era Hominins and Archaeology
- Indigenous Studies and Ecology
- Genomics and Phylogenetic Studies
- Neonatal Health and Biochemistry
- Wildlife Ecology and Conservation
- Primate Behavior and Ecology
- Cardiac electrophysiology and arrhythmias
- PARP inhibition in cancer therapy
- Language and cultural evolution
- Nutrition, Genetics, and Disease
- Evolution and Genetic Dynamics
- Paleopathology and ancient diseases
- Cardiac pacing and defibrillation studies
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- Names, Identity, and Discrimination Research
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
University of Oxford
2010-2023
Università Cattolica del Sacro Cuore
2009-2021
Universidade de Santiago de Compostela
2006-2016
Fundación Pública Galega de Medicina Xenómica
2015
Sapienza University of Rome
2011-2014
Centre for Biomedical Network Research on Rare Diseases
2011
Recently, the debate on origins of major European Y chromosome haplogroup R1b1b2-M269 has reignited, and opinion moved away from Palaeolithic to notion a younger Neolithic spread these chromosomes Near East. Here, we address this by investigating frequency patterns diversity in largest collection yet assembled. Our analysis reveals no geographical trends diversity, contradiction expectation under hypothesis, suggests an alternative explanation for apparent cline recently described. We...
Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into history our species. Several landmark papers described genomes ancient humans across West Eurasia, demonstrating presence large-scale, dynamic population movements over last 10,000 such that ancestry present-day populations is likely to be a mixture several groups [1-7]. While these efforts are bringing details Eurasian prehistory increasing focus,...
A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial structure.
Mitochondrial DNA (mtDNA) lineages of macro-haplogroup L (excluding the derived L3 branches M and N) represent majority typical sub-Saharan mtDNA variability. In Europe, these mtDNAs account for <1% total but, when analyzed at level control region, they show no signals having evolved within European continent, an observation that is compatible with a recent arrival from African continent. To further evaluate this issue, we 69 mitochondrial genomes belonging to various sublineages wide...
The study of Y chromosome variation has helped reconstruct demographic events associated with the spread languages, agriculture, and pastoralism in sub-Saharan Africa, but little attention been given to early history continent. In order overcome this lack knowledge, we carried out a phylogeographic analysis haplogroups A B broad data set populations. These two lineages are particularly suitable for objective because they most deeply rooted branches genealogy. Their distribution is almost...
We sequenced genomes from a ∼7,000 year old early farmer Stuttgart in Germany, an ∼8,000 hunter-gatherer Luxembourg, and seven hunter-gatherers southern Sweden. analyzed these data together with other ancient 2,345 contemporary humans to show that the great majority of present-day Europeans derive at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry all but not Near Easterners; Ancient North Eurasians (ANE), were most closely...
A consensus on Bantu-speaking populations being genetically similar has emerged in the last few years, but demographic scenarios associated with their dispersal are still a matter of debate. The frontier model proposed by archeologists postulates different degrees interaction among incoming agropastoralist and resident foraging groups presence "static" "moving" frontiers. By combining mitochondrial DNA Y chromosome data collected from several southern African populations, we show that...
The animal and plant biodiversity of the Italian territory is known to be one richest in Mediterranean basin Europe as a whole, but does genetic diversity extant human populations show comparable pattern? According number studies, structure retains signatures complex peopling processes which took place from Paleolithic modern era. Although observed patterns highlight remarkable degree heterogeneity, they do not, however, take into account an important source variation. In fact, Italy home...
Background According to archaeological records and historical documentation, Italy has been a melting point for populations of different geographical ethnic matrices. Although favorite subject numerous population genetic studies, patterns have never analyzed comprehensively, including uniparental autosomal markers throughout the country. Methods/Principal Findings A total 583 individuals were sampled from across Italian Peninsula, ten distant (if homogeneous by language) communities — two...
Abstract The Tyrolean Iceman is an extraordinarily well-preserved natural mummy that lived south of the Alpine ridge ~5,200 years before present (ybp), during Copper Age. Despite studies have investigated his genetic profile, relation Iceman´s maternal lineage with present-day mitochondrial variation remains elusive. Studies shown DNA (mtDNA) belongs to a novel haplogroup K1 (K1f) not found in extant populations. We analyzed complete mtDNA sequences 42 K bearing individuals from populations...
The relationship between genetic and linguistic diversification in human populations has been often explored to interpret some specific issues history. Albanian-speaking minorities of Sicily Southern Italy (Arbereshe) constitute an important portion the ethnolinguistic variability Italy. Their isolation from neighboring Italian their documented migration history, make such particularly effective for investigating interplay cultural, geographic historical factors. Nevertheless, extent...