Cláudio M. Bravi
A5058335467- Forensic and Genetic Research
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Forensic Anthropology and Bioarchaeology Studies
- Race, Genetics, and Society
- Mitochondrial Function and Pathology
- Genetic Associations and Epidemiology
- Archaeology and ancient environmental studies
- Indigenous Cultures and History
- Genetic and phenotypic traits in livestock
- Yersinia bacterium, plague, ectoparasites research
- Metabolism and Genetic Disorders
- Argentine historical studies
- Pleistocene-Era Hominins and Archaeology
- Evolution and Paleontology Studies
- Indigenous Studies and Ecology
- Plant and animal studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Wildlife Ecology and Conservation
- Molecular Biology Techniques and Applications
- Genomics and Rare Diseases
- History and Politics in Latin America
- Migration, Education, Indigenous Social Dynamics
- RNA and protein synthesis mechanisms
- Insect and Arachnid Ecology and Behavior
Instituto Multidisciplinario de Biología Celular
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Comisión de Investigaciones Científicas
2015-2025
Universidad Nacional de La Plata
2014-2024
Centro Científico Tecnológico - La Plata
2011-2018
National University of Jujuy
2011
Universidad de Antioquia
2010
Universität Hamburg
2006
Instituto Venezolano de Investigaciones Científicas
2002
Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about intial colonization remain unclear. To investigate pioneering phase in we analyzed total 623 complete mtDNAs and Asia, including 20 new seven Asia. This sequence data was used direct high-resolution genotyping American 26 populations. Here describe more genetic diversity within founder population than previously reported. The newly resolved...
Duplications and deletions in the human genome can lead to variation copy number for genes genomic loci among humans. Such variants reveal evolutionary patterns have implications health. Sudmant et al. examined copy-number across 236 individual genomes from 125 populations. Deletions were under more selection, whereas duplications showed population-specific structure. Interestingly, Oceanic populations retain large postulated originated an ancient Denisovan lineage. Science , this issue...
Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with least amount information about sequence variation entire DNAs. In this study, comprehensive overview all DNA (mtDNA) genomes four pan-American A2, B2, C1, and D1 is provided by revising scattered throughout GenBank literature, adding 14 novel mtDNA sequences. The phylogenies reveal large sub-haplogroups but suggest...
The rich fossil record of horses has made them a classic example evolutionary processes. However, while the overall picture equid evolution is well known, details are surprisingly poorly understood, especially for later Pliocene and Pleistocene, c. 3 million to 0.01 years (Ma) ago, nowhere more so than in Americas. There no consensus on number species or even lineages that existed these continents. Likewise, origin endemic South American genus Hippidion unresolved, as phylogenetic position...
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental in over 6,500 evaluate impact regional variation on physical appearance. We find American components correspond geographically present-day structure groups, sources non-Native ancestry, admixture timings, match documented migratory flows. also...
After several years of research, there is now a consensus that America was populated from Asia through Beringia, probably at the end Pleistocene. But many details such as timing, route(s), and origin first settlers remain uncertain. In last decade genetic evidence has taken on major role in elucidating peopling Americas. To study early South America, we sequenced control region mitochondrial DNA 300 individuals belonging to indigenous populations Chile Argentina, also obtained seven complete...
Phylogenies of indigenous microbes have been used as surrogates for the origins hosts that carry them. Conversely, polymorphisms may be to date spread a microbial species when information about their host populations is available. Therefore, we examined in Helicobacter pylori, which persistently colonize human stomach, test hypothesis they ancient inhabitants humans. Three H. pylori loci previously shown phylogeographic affinity analyzed two with different ethnic from Venezuela. In group...
Abstract A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS‐I), a fraction them was also studied seven biallelic Y‐chromosome polymorphisms. Nineteen HVS‐I lineages were detected, which showed distinct distributions tribes. The G ST value obtained with mtDNA data is about 5 times higher Guarani as compared to Kaingang, suggesting level...
Phantom mutations are systematic artifacts generated in the course of sequencing process. Contra common belief these artificial nearly ubiquitous results, albeit at frequencies that may vary dramatically. The amount depends not only on sort automated sequencer and chemistry employed, but also other lab-specific factors. An experimental study executed four samples under various combinations conditions revealed a number phantom occurring same sites mitochondrial DNA (mtDNA) repeatedly. To...
Abstract Two Bolivian samples belonging to the two main Andean linguistic groups (Aymaras and Quechuas) were studied for mtDNA Y‐chromosome uniparental markers evaluate sex‐specific differences give new insights into demographic processes of region. mtDNA‐coding polymorphisms, HVI‐HVII control regions, 17 Y‐STRs, three SNPs typed in well‐defined populations with adequate size samples. The showed more genetic than Y‐chromosome. For mtDNA, 81% Aymaras 61% Quechuas presented haplogroup B2....
We sequenced genomes from a ∼7,000 year old early farmer Stuttgart in Germany, an ∼8,000 hunter-gatherer Luxembourg, and seven hunter-gatherers southern Sweden. analyzed these data together with other ancient 2,345 contemporary humans to show that the great majority of present-day Europeans derive at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry all but not Near Easterners; Ancient North Eurasians (ANE), were most closely...
The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting Mestizos, which constitute the main Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms 742 Mestizos 10 populations...
We analyzed 391 samples from 12 Argentinian populations the Center-West, East and North-West regions with Illumina Human Exome Beadchip v1.0 (HumanExome-12v1-A). did Principal Components analysis to infer patterns of populational divergence migrations. identified proportions European, African Native American ancestry found a correlation between distance Buenos Aires proportion ancestry, where highest corresponds Northernmost populations, which is also furthest capital. Most European sources...
Abstract Introduction Southern Africa has been inhabited by hunter‐gatherers for at least 20,000 years and received diverse immigration flows in the last 2000 years. The original inhabitants have interacted with pastoralist migrants from Eastern (∼2000 ybp), followed southern Bantu migration arriving some 1000 ybp, more recently European Asian settlers after 17th century. Many of Khoekhoe San either become extinct or disappeared through admixture South (SA), a sex‐biased manner involving...
We analysed the frequency of six Y-specific polymorphisms in 105 Amerindian males from seven different populations, 42 Caucasian males, and a small number African, Chinese, Melanesian origin. The combination three studied produced four Y-haplogroups. haplogroup A (non-variant) was most frequent one. Eighty-five percent Amerindians showing have alphoid II (αhII) DYS19A markers, an association that is found only 10% Caucasians has not been detected Asiatics Africans. Haplogroups C (YAP+) D...