A5018736214- Forensic Anthropology and Bioarchaeology Studies
- Morphological variations and asymmetry
- Pleistocene-Era Hominins and Archaeology
- Forensic and Genetic Research
- Genetic and phenotypic traits in livestock
- Evolution and Paleontology Studies
- melanin and skin pigmentation
- dental development and anomalies
- Medical and Biological Sciences
- Genetic Associations and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Marine animal studies overview
- Archaeology and ancient environmental studies
- Skin Protection and Aging
- Orthodontics and Dentofacial Orthopedics
- Evolutionary Psychology and Human Behavior
- Genetic Mapping and Diversity in Plants and Animals
- Paleopathology and ancient diseases
- Spanish Linguistics and Language Studies
- Bat Biology and Ecology Studies
- Indigenous Studies and Ecology
- 3D Surveying and Cultural Heritage
- Race, Genetics, and Society
- Cleft Lip and Palate Research
- Primate Behavior and Ecology
Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2023-2024
Centro Científico Tecnológico Patagónico
2015-2024
Ministerio de Ciencia y Tecnología
2023-2024
Biogéosciences
2022
Université Bourgogne Franche-Comté
2022
École Pratique des Hautes Études
2022
Centre National de la Recherche Scientifique
2022
Mexican Social Security Institute
2020
Universitat de Barcelona
2001-2020
Centro Científico Tecnológico - San Juan
2018-2020
The current genetic makeup of Latin America has been shaped by a history extensive admixture between Africans, Europeans and Native Americans, process taking place within the context geographic social stratification. We estimated individual ancestry proportions in sample 7,342 subjects ascertained five countries (Brazil, Chile, Colombia, México Perú). These individuals were also characterized for range physical appearance traits self-perception ancestry. distribution this reveals population...
Abstract We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. evaluated 14 traits on an ordinal scale and found significant ( P values<5 × 10 −8 ) at single-nucleotide polymorphisms (SNPs) four genomic regions three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) wing (7p13 20p11). In subsample of ∼3,000 individuals we obtained quantitative related to 9 the phenotypes and, also, measure nasion position. Quantitative analyses...
Abstract We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial (beard thickness, monobrow, eyebrow thickness). found 18 signals reaching significance ( P values 5 × 10 −8 to 3 −119 ), including novel associations. These include loci shape balding, the first reported beard thickness. A newly identified locus influencing includes Q30R substitution Protease Serine S1 family member 53 PRSS53 ). demonstrate...
Abstract We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. found eighteen signals at twelve genomic regions. These include one novel locus (in 10q26) three loci eye 1q32, 20q13 22q12). demonstrate the presence multiple independent 11q14 15q13 regions (comprising GRM5/TYR HERC2/OCA2 genes, respectively) several epistatic interactions among independently associated alleles. Strongest with 19p13 was observed an Y182H missense variant...
Abstract Twenty‐two years ago, Greenberg, Turner and Zegura ( Curr. Anthropol. 27,477–495, 1986) suggested a multidisciplinary model for the human settlement of New World. Since their synthesis, several studies based mainly on partial evidence such as skull morphology molecular genetics have presented competing, apparently mutually exclusive, hypotheses. These contradictory views are represented by genetic‐based Single Wave or Out Beringia models cranial morphology‐based Two...
Abstract Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight human structure. However, little is known about the degree of and non‐genetic influences on phenotypic expression functionally based traits. Many studies assessed heritability craniofacial traits, but complex patterns correlation among disregarded. This a pitfall as skull strongly integrated. Here we reconsider evolutionary potential craniometric by assessing...
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental in over 6,500 evaluate impact regional variation on physical appearance. We find American components correspond geographically present-day structure groups, sources non-Native ancestry, admixture timings, match documented migratory flows. also...
It has long been unclear whether the different derived cranial traits of modern humans evolved independently in response to separate selection pressures or they resulted from inherent morphological integration throughout skull. In a novel approach this issue, we combine evolutionary quantitative genetics and geometric morphometrics analyze genetic phenotypic human skull shape. We measured skulls ossuary Hallstatt (Austria), which offer unique opportunity because are associated with...
Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find significant at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion antitragus (linear regression P values 2 × 10(-8) to 3 10(-14)). Four traits are associated with functional variant the Ectodysplasin A receptor (EDAR) gene, key regulator embryonic skin appendage development. confirm expression Edar developing...
We carried out a genome-wide association study in Latin Americans and identified novel face morphology loci..
Environmental factors are assumed to play an important role in the shaping of craniofacial morphology. Here we propose a statistical approach which can be utility estimating magnitude and localization particular nongenetic factor upon specific functional components skull. Our analysis is combination previous attempts apportionment variance application craniofunctional theory. The effect subsistence strategy on was studied 18 populations hunter-gatherers farmers from South America. Results...
Abstract Masticatory loading is one of the main environmental stimuli that generate craniofacial variation among recent humans. Experimental studies on a wide variety mammals, including those with retrognathic postcanine teeth, predict responses to masticatory will be greater in occlusal plane, inferior rostrum, and regions associated attachments temporalis masseter muscles. Here we test these experimentally‐derived predictions an extinct human population from middle upper Ohio valley...
Background and Aims Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC relatively rare in Europe. Here, we investigate causal effects of risk factors considered current prevention programs as well C‐reactive protein (CRP) level marker chronic inflammation. Approach Results We applied two‐sample Mendelian randomization (MR) using publicly available data our own from retrospective Chilean prospective...
Proportionality of phenotypic and genetic distance is crucial importance to adequately focus on population history structure, it depends the proportionality covariance. Constancy covariances unlikely without constancy covariation if latter a substantial component former. If patterns are found be relatively stable, most probable explanation that covariance matrices also stable. Factors like morphological integration account for such stability. Morphological can studied by analyzing...
Abstract Several studies on craniofacial morphology showed that most Paleoindians, who were the first settlers of New World, clearly differ from modern Amerindians and East Asians, their supposed descendants sister group, respectively. Here we present new evidence supporting this view Late Pleistocene/Early Holocene horizon Mexico, as well complete set dated Paleoindian remains. We analyzed phenotypic resemblance early Mexicans with other South Paleoamerican human series. Two independent...
Different scenarios attempting to describe the initial phases of human dispersal from Asia into New World have been proposed during last two decades. However, some aspects concerning population affinities among early and modern Asians Native Americans remain controversial. Specifically, contradictory views based mainly on partial evidence such as skull morphology or molecular genetics led hypotheses "Two Waves/Components" "Single Wave" "Out Beringia" model, respectively. Alternatively, an...
Antisocial and criminal behaviors are multifactorial traits whose interpretation relies on multiple disciplines. Since these interpretations may have social, moral legal implications, a constant review of the evidence is necessary before any scientific claim considered as truth. A recent study proposed that men with wider faces relative to facial height (fWHR) more likely develop unethical behaviour mediated by psychological sense power. This research was based reports suggesting sexual...
Abstract Since the beginning of systematic archaeological studies in southern Patagonia (Argentina and Chile), projectile points have played an important role as cultural markers. A sequence point types was established according to their changes size shape. These stone tools, along with others evidences, served differentiate a series “culturai periods” which were, for decades, frame reference understand evolution southernmost Patagonia. Although later researches questioned several these...