A5050590164- Forensic and Genetic Research
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Forensic Anthropology and Bioarchaeology Studies
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Race, Genetics, and Society
- Archaeology and ancient environmental studies
- Genetic Associations and Epidemiology
- Pleistocene-Era Hominins and Archaeology
- Pacific and Southeast Asian Studies
- Endometrial and Cervical Cancer Treatments
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Genetic Mapping and Diversity in Plants and Animals
- Philippine History and Culture
- Higher Education Teaching and Evaluation
- BRCA gene mutations in cancer
- Yersinia bacterium, plague, ectoparasites research
- T-cell and B-cell Immunology
- Environmental DNA in Biodiversity Studies
- Economic and Financial Impacts of Cancer
- Social Sciences and Policies
- Environmental and Cultural Studies in Latin America and Beyond
- Lung Cancer Treatments and Mutations
Spanish Ovarian Cancer Research Group
2022-2025
Clinica Universidad de Navarra
2022-2025
KU Leuven
2024
University Medical Center Hamburg-Eppendorf
2024
Centre Hospitalier Universitaire de Liège
2024
Universität Hamburg
2024
National Cancer Center
2024
Universidad Complutense de Madrid
2010-2022
Universidad Autónoma del Estado de Hidalgo
2002-2007
Universitat de Barcelona
1990-2005
Recurrent cervical cancer is a life-threatening disease, with limited treatment options available when disease progression occurs after first-line combination therapy.
Abstract Over the last 500 years, admixture among Amerindians, Europeans, and Africans, principally, has come to shape present‐day gene pool of Mexicans, particularly Mestizos, who represent about 93% total Mexican population. In this work, we analyze genetic data 13 combined DNA index system‐short tandem repeats (CODIS‐STRs) in 1,984 unrelated Mestizos representing 10 population samples from different regions Mexico, namely North, West, Central, Southeast. The analysis molecular variance...
It has been suggested that the higher susceptibility of Hispanics to metabolic disease is related their Native American heritage. A frequent cholesterol transporter ABCA1 (ATP-binding cassette A1) gene variant (R230C, rs9282541) apparently exclusive individuals was associated with low high-density lipoprotein (HDL-C) levels, obesity and type 2 diabetes in Mexican Mestizos. We performed a more extensive analysis this 4405 Americans 863 from other ethnic groups investigate genetic evidence...
Y-linked markers are suitable loci to analyze genetic diversity of human populations, offering knowledge medical, forensic, and anthropological interest. In a population sample 206 Mestizo males from western Mexico, we analyzed two binary (M3 YAP) six Y-STRs, adding the analysis data Mexican Mestizos Amerindians, relevant worldwide populations. The paternal ancestry estimated in Mexican-Mestizos was mainly European (60-64%), followed by Amerindian (25-21%), African ( approximately 15%)....
Extensive European and African admixture coupled with loss of Amerindian lineages makes the reconstruction pre-Columbian history Native Americans based on present-day genomes extremely challenging. Still open questions remain about dispersals that occurred throughout continent after initial peopling from Beringia, especially concerning number dynamics diffusions into South America. Indeed, if environmental historical factors contributed to shape distinct gene pools in Andes Amazonia, origins...
Maintenance olaparib demonstrated clinical activity for progression-free survival in patients without a germline BRCA1 and/or BRCA2 mutation (non-gBRCAm) who had platinum-sensitive relapsed ovarian cancer the phase IIIb, open-label, single-arm, non-comparator, international OPINION trial (NCT03402841). We report final overall (OS; secondary endpoint), prespecified endpoint updates and ad hoc OS analysis by homologous recombination deficiency (HRD) somatic BRCAm (sBRCAm) status. Patients with...
Abstract An evolutionary, diachronic approach to the phenotypic craniofacial pattern arisen in a human population after high levels of admixture and gene flow was achieved by means geometric morphometrics. Admixture has long been studied molecular data. Nevertheless, few efforts have made explain morphological outcome samples. The Spanish‐Amerindian contact can be considered good scenario for such an analysis. Here we present comparative analysis shape changes observed between two putative...
The study of genetic information can reveal a reconstruction human population's history. We sequenced the entire mtDNA control region (positions 16.024 to 576 following Cambridge Reference Sequence, CRS) 605 individuals from seven Mesoamerican indigenous groups and one Aridoamerican Greater Southwest previously defined, all them in present Mexico. Samples were collected directly populations, application an individual survey made it possible remove related or with other origins samples....
The genetic characterization of Native American groups provides insights into their history and demographic events. We sequenced the mitochondrial D-loop region (control region) 520 samples from eight Mexican indigenous groups. In addition to an analysis diversity, structure relationship between 28 populations, we applied Bayesian skyline methodology for a deeper insight Mesoamerica. AMOVA tests applying cultural, linguistic geographic criteria were performed. MDS plots showed central...
ABSTRACT Objective To analyze the origin, structure, relationships, and recent admixture in Mexican Native groups based on 15 STRs commonly used human identification. Methods We analyzed 39 population samples using STR databases AmpF l STR® Identifiler kit ( n = 3,135), including Mexican‐Mestizos (admixed), European African populations, as reference. Results Based upon effective size (Ne) differences, were clustered into three regions: i) Center‐Southeast , characterized by larger Ne,...
The Mexica Empire reached an outstanding social, economic and politic organization among Mesoamerican civilizations. Even though archaeology history provide substantial information about their past, biological origin the demographic consequences of settlement in Central Valley Mexico remain unsolved. Two main hypotheses compete to explain origin: a social reorganization groups already present after fall Classic centres or population replacement by migrants from north consequent setting up...
Despite the efforts made to reconstruct history of modern humans, there are still poorly explored regions that key for understanding phylogeography our species. One them is Philippines, which crucial unravel colonization Southeast Asia and Oceania but where little known about when how first humans arrived. In order shed light into this settlement, we collected samples from 157 individuals Philippines with four grandparents belonging same region mitochondrial variants older than 20,000 years....
A multivariate analysis of four prehistoric and nine historic populations from the Iberian Peninsula Balearic Islands with large sample sizes (n > 30 individuals for neurocranium n 15 facial skeleton) is presented, considering 874 male 557 female skulls using 20 craniometric measurements. Cluster analyses have been undertaken squared Euclidean distance as a measure proximity average linkage between groups (UPGMA), neighbor-joining algorithms branching method, bootstrap was used to assess...
Abstract We report data on the genetic variation of Tepehua population based 15 autosomal microsatellites. The Tepehua, whose language belongs to Totonac family, are settled throughout Sierra Madre Oriental in Mexico and constitute a group demographic decline. results suggest that remained isolated large part its history. Phylogenetic analyses performed with other indigenous admixed populations Mesoamerica allow us address their biological affinity between Huastecos due previous shared...
Background: Gene flow among human populations is generally interpreted in terms of complex patterns, with the observed gene frequencies being consequence entire genetic and demographic histories population.Aims: This study performs a high-resolution analysis Y-chromosome haplogroup E Western Andalusians (Huelva province). The information presented here provides new insights into migration processes that took place throughout Mediterranean space tries to evaluate its impact on current...
Abstract Allele frequencies for 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D19S433, HUMVWA31A, HUMTPOX, D18S51, D3S1358, HUMTHO1, D13S317, D16S539, D2S1338, D5S818, and HUMFGA) were analyzed in a Mexican population: Choles from Chiapas State. The aim of the study was to obtain accurate allele data other genetic parameters forensic interest on Amerindian ethnic groups Mexico, using an automatic method commercial amplification kit. agreement with HWE (Hardy-Weinberg equilibrium) confirmed...