A5065581191- Natural Compounds in Disease Treatment
- High Altitude and Hypoxia
- Psidium guajava Extracts and Applications
- Phytochemistry Medicinal Plant Applications
- Forensic and Genetic Research
- Pharmaceutical studies and practices
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Natural Antidiabetic Agents Studies
- SARS-CoV-2 detection and testing
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacology and Obesity Treatment
- Phytochemicals and Medicinal Plants
- Health and Medical Education
- Vitamin K Research Studies
- Biosimilars and Bioanalytical Methods
- Advances in Cucurbitaceae Research
- Botanical Research and Applications
- Ethics and bioethics in healthcare
- Ethnobotanical and Medicinal Plants Studies
- Pregnancy and preeclampsia studies
- Plant and soil sciences
- Veterinary Pharmacology and Anesthesia
- Coenzyme Q10 studies and effects
- Botanical Research and Chemistry
Universidad de San Martín de Porres
2016-2025
Universidad Nacional del Altiplano
2024
Ministerio de Educación del Perú
2023
Revista Conamed
2020
Medico
2020
Instituto de Investigación Nutricional
2019
Universidad Peruana Cayetano Heredia
2018
Centro de Ornitología y Biodiversidad
2018
Hospital de Clínicas de Porto Alegre
2013
Red de Investigación Cardiovascular
2013
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental in over 6,500 evaluate impact regional variation on physical appearance. We find American components correspond geographically present-day structure groups, sources non-Native ancestry, admixture timings, match documented migratory flows. also...
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
Previous studies indicate that individuals at high altitudes have a lower pain threshold than those living sea level. This study evaluates the differences in perception among young people an altitude of 3800 m and after acute exposure to severe hypoxic environment more 5100 m. Fourteen (BMI 22.6 ± 1.2 age 23.3 1.9 years) residing city Puno (3825 m) participated ascent Populated Center La Rinconada (>5100 m). The unilateral ischemia provocation test was used, applying pressure with manual...
The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates detoxification these metabolites by conjugating them with glutathione. presence CYP1A1*2A genetic variant intensifies production metabolites, and deletion gene ( GSTM1*0 ) impairs their detoxification. This enzymatic imbalance leads to formation DNA adducts, which are known contribute cancer other diseases. Given importance studying...
The Altiplano region of the South American Andes is marked by an inhospitable climate to which autochthonous human populations adapted and then developed great ancient civilizations, such as Tiwanaku culture Inca Empire. Since pre-Columbian times, different rulers established themselves around Titicaca Poopo Lakes. By time arrival Spaniards, Aymara Quechua languages were predominant on under rule Incas, although occurrence other spoken languages, Puquina Uruquilla, suggests existence ethnic...
Summary This study focuses on the genetic history of Quechua‐Lamistas, inhabitants Lamas Province in San Martin Department, Peru, who speak their own distinct variety Quechua family languages. It has been suggested that different pre‐Columbian ethnic groups from Peruvian Amazonia, like Motilones or “shaven heads”, assimilated language and then formed current native population Lamas. However, many Quechua‐Lamistas claim to be direct descendants Chankas, a famous indigenous group escaped Inca...
The diversity of the five single nucleotide polymorphisms located in genes TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied a total 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, Kaiowá populations, characterized as Native American or having high level (> 90%) ancestry. In addition, published data pertaining 100 persons from other populations (Surui,...
Background: Chronic exposure to severe hypoxia causes an increase in hematocrit (Hct) and hemoglobin concentration ([Hb]), which can lead Excessive Erythrocytosis (EE), could impact physical performance. This work aims determine the differences six-minute walking test (6MWT) outputs between EE healthy subjects residing at more than 5000 meters. Methods: A prospective, cross-sectional study was performed on 71 men (36 25 suffering EE) living La Rinconada, Peru (5100 m). Basal levels of [Hb]...
Chronic Mountain Sickness (CMS) syndrome, combining excessive erythrocytosis and clinical symptoms in highlanders, remains a public health concern high-altitude areas, especially the Andes, with limited therapeutic approaches. The objectives of this study were to assess CMS-highlanders permanently living La Rinconada (5100-5300 m, Peru, highest city world), early efficacy acetazolamide (ACZ) atorvastatin reduce hematocrit (Hct), as well underlying mechanisms focusing on intravascular...
Carta al Editor (Sin resumen)
Objective: To demonstrate the presence of alkaloids and phenols in Minthostachys mollis (muña) flower branch, to compare results with those five informally traded muña samples bought Lima - Peru. Materials methods: A sample was collected department Junín (located at 321 km from 4113 m.a.s.l.), Peru, according Cerrate E. Ramagosa et. al. method, identified by a botanic specialist. Other without sanitary registry were different markets. The phytochemical screening performed using method...
Carta al Editor (sin resumen)
Introducción: La expansión acelerada del SARS-CoV-2 trajo consigo una crisis mundial, y serie de estudios recomendaciones para manejarlo; mientras que previos a la pandemia, evidencia elevada prevalencia automedicación en estudiantes universitarios. Objetivo: Identificar frecuencia características contra COVID-19 con fármacos y/o plantas medicinales los Universidad Nacional Amazonía Peruana (UNAP), Iquitos, Loreto-Perú, durante primera ola por COVID-19. Material Métodos: Se realizó un...
Introduction:Different studies indicate that Maytenus has many effects and M. obtusifolia species a central nervous system depressant effect.Objective: To determine antipsychotic behavior modifying effect of the macrocarpa (Ruiz & Pav.) Briq.ethanolic extract, using forced swim test Irwin test.Method: 77 albino mice were used, with an average weight 25 g.They split into 7 groups they administered 200 mg/kg, 400 600 800 1000 caffeine 32 diazepam mg/ kg, fluoxetine 30 haloperidol 5 distilled...
Objective: To determine valproic acid level/dose ratio (ND) and the influence of enzyme-inducing non-enzymeinducing drugs in volunteer patients city Mérida, Venezuela. Materials methods: An experimental, observational, prospective, cross-sectional study was conducted at Hospital de After undergoing inclusion exclusion criteria process, signed an informed consent individually voluntarily. The protocol consisted collecting blood from 88 (42 males y 46 females) 16 to 68 years old, who had...
Introducción. Estudios preclínicos evidencian efectos dosis dependiente sobre la analgesia e inflamación y neurotoxicidad de las hojas, corteza raíz J. curcas L. El propósito del estudio fue evaluar actividad analgésica neurofarmacológica fracciones semilla Métodos. Estudio experimental, preclínico prospectivo. Se distribuyeron 48 ratones en seis grupos control: ácido acético, diclofenaco, tramadol, agua destilada, diazepam cafeína. Cuatro experimentales: fracción soluble a 500 mg/kg no 250,...
Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim this study is evaluate effects on inflammation and the nervous system ethanol extract J. seeds. Materials methods: It was 64 mice divided 8 groups; respectively, 4 groups received 400, 600, 800 1000 mg/kg seed; rest intake Diclofenac, Diazepam, Caffeine control group not any substance. evaluated by Carrageenan-Induced paw oedema test Paw skin temperature. Neurological...
Background Previous studies showed that residents of higher elevations have lower glucose levels. Our objective in this study is to determine the basal and postprandial levels apparently healthy permanent miner population center La Rinconada located 5100 meters (m) above sea level. Method Forty male were studied. The oral tolerance test was used evaluate glycemia at 1, 2, 3 h. Results individuals had a mean age 43.95 ± 8.54 years. Basal subjects without excessive erythrocytosis (EE) 73.3 7.9...