A5037343711- Renal Transplantation Outcomes and Treatments
- Lysosomal Storage Disorders Research
- Viral-associated cancers and disorders
- Renal and Vascular Pathologies
- Studies on Chitinases and Chitosanases
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Cervical Cancer and HPV Research
- RNA regulation and disease
- Diabetes and associated disorders
- Pharmacogenetics and Drug Metabolism
- Dengue and Mosquito Control Research
- Statistical Methods in Clinical Trials
- Moyamoya disease diagnosis and treatment
- Genetic and Kidney Cyst Diseases
- Eosinophilic Disorders and Syndromes
- Ichthyology and Marine Biology
- Cancer Genomics and Diagnostics
- Proteins in Food Systems
- Liver Disease and Transplantation
- Galectins and Cancer Biology
- Renal Diseases and Glomerulopathies
- Lymphoma Diagnosis and Treatment
- Diabetes Treatment and Management
National University of Rosario
2005-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2018
Instituto de Biología Molecular y Celular de Rosario
2007-2018
Hospital Universitario de Canarias
2007-2012
Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...
All-cause mortality is high after kidney transplantation (KT), but no prognostic index has focused on predicting in KT using baseline and emergent comorbidity KT.A total of 4928 recipients were used to derive a risk score mortality. Patients randomly assigned two groups: modeling population (n=2452), create new index, testing (n=2476), test this index. Multivariate Cox regression model coefficients (age, weight, time dialysis, diabetes, hepatitis C, delayed graft function) within the first...
The beneficial effect of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) in kidney transplant recipients on modern immunosuppression is not yet well established. Our objective was to investigate the impact use ACEI/ARB patient and graft survival a cohort recipients. A total 990 patients, who received single deceased donor at our institution between 1996 2005, were included this longitudinal study. All-cause mortality death-censored loss primary...
More than 170 human papillomavirus (HPV) types have been completely sequenced, curated and divided into five genera: Alphapapillomavirus , Betapapillomavirus Gammapapillomavirus Mupapillomavirus Nupapillomavirus . With the application of PCR methods, hundreds putative novel HPV identified as amplicons in mucosa skin. However, at present there are no studies reporting a systematic search currently known L1 their phylogenetic relationships. This survey revealed existence least 202 different...
Data on the combined associations of albuminuria and estimated glomerular filtration rate (eGFR) with renal transplant outcomes are limited. Our objective was to explore how could be predicted by a variable early low-grade allograft dysfunction.We studied cohort adult deceased-donor kidney recipients who were subdivided into four groups according median (100 mg/day, interquartile range, 0-470 mg/day) eGFR (60 mL/min/1.73 m(2); 30-73 m(2)) at third month posttransplantation as follows: group...
In advanced Fabry nephropathy stages, enzyme replacement theraphy (ERT) efficacy decreases, due to its impossibility reverse renal fibrosis. Therefore, the finding of early kidney fibrosis biomarkers in affected patients is interest. During miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-β (TGF-β), miR-29 miR-200 family supressors) inhibited TGF-β. The aim this study analyze probability that disease (FD) with some clinical variables can present an...
ABSTRACT Molecular diagnostics based on reverse transcription (RT)-PCR are routinely complicated by the lack of stable internal controls, leading to falsely negative results. We describe a strategy produce competitive control (CIC) Qβ phage derivative (recombinant [rQβ]) bearing primers KY78 and KY80, which widely used in detection hepatitis C virus (HCV). rQβ was RNase resistant at 4°C for 452 days SM medium (0.1 M NaCl, 8 mM MgSO 4 ·7H 2 O, 50 Tris HCl [pH 7.5], 2% gelatin) 125 after...
The present study aimed to evaluate the impact caused by 2016 World Health Organization (WHO) diagnostic classification of gliomas in 139 patients studied Argentina. Formalin‑fixed paraffin‑embedded tissues were used for histological and immunohistochemical analysis [glial fibrillary acidic protein, KI67, synaptophysin isocitrate dehydrogenase (IDH)1‑R132H]. DNA from formalin‑fixed was molecular analysis: 1p/19q co‑deletion mutation status IDH gene. These experiments performed direct Sanger...
Renal involvement is associated with a greater morbidity and mortality in Fabry disease. Pathological albuminuria, the first nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo-interstitial fibrosis glomerulosclerosis are present or may precede onset of pathological albuminuria. In renal cells, exposure to Lyso-Gb3 correlated increased expression Transforming Growth Factor- β eta (TGF- ). miR-21, miR-192, miR-433 that promote...
Malignant gliomas are the most common primary central nervous system tumor in adults. Despite current therapeutics, these tumors associated with poor prognosis and a median survival of 16 to 19 months. This highlights need for innovative treatments this incurable disease. Rac1 has long been progression plays key role glioma's infiltrative invasive nature. The aim study is evaluate 1A-116 molecule, inhibitor, as targeted therapy aggressive We found that targeting inhibits cell proliferation...
Fabry disease (FD) clinical manifestations often start in childhood. Among the FD complications, renal failure causes significant morbidity and mortality. Early diagnosis treatment of nephropathy children may be critical to preserve function. In proteinuric progressive nephropathies it has been described that pro-fibrotic miR-21, miR-192, miR-433 families are activated anti-fibrotic miR-29 miR-200 inhibited. Objective: Analyze urinary excretion microRNAs related fibrosis patients with mild...
Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in disease development. We have previously observed Hyaluronic Acid (HA) serum increase active RA patients (DAS 28-4 > 2.6) which might be responsible for erythrocyte deformability, estimated by Rigidity Index (RI). Objective: In present study, we analyzed one hundred if anti-EBV antibodies (TsEBV) and HA RI levels are related...