Karla Escobar

ORCID: 0000-0002-8722-0350
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About
Contact & Profiles
Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • Renal Transplantation Outcomes and Treatments
  • T-cell and B-cell Immunology
  • Bacillus and Francisella bacterial research
  • History and Politics in Latin America
  • Legal processes and jurisprudence
  • Blood groups and transfusion
  • COVID-19 Clinical Research Studies
  • Comparative constitutional jurisprudence studies
  • Intramuscular injections and effects
  • Political and Social Dynamics in Chile and Latin America
  • Pharmacogenetics and Drug Metabolism
  • Pharmacological Effects and Toxicity Studies
  • Employment and Welfare Studies
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Economic and Social Development
  • Antibiotic Use and Resistance
  • Bacterial Identification and Susceptibility Testing
  • Public Policy and Governance
  • Neutropenia and Cancer Infections
  • Vaccine Coverage and Hesitancy
  • Biosimilars and Bioanalytical Methods
  • Cytomegalovirus and herpesvirus research
  • Political Theory and Democracy
  • Xenotransplantation and immune response

Hospital General San Juan de Dios
2022-2024

Hospital Clínic de Barcelona
2022-2023

Liga Nacional Contra el Cáncer
2022-2023

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023

Universitat de Barcelona
2023

Jönköping University
2023

University of San Carlos of Guatemala
2022

Henry Ford Health System
2022

Universidad de Los Andes
2020

Universidad Nacional Autónoma de Nicaragua-León
2020

Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx the Latin American and Caribbean (LAC) region remains scarce, with limited information some populations. Thus, extrapolations are complicated, especially mixed In this paper, we reviewed analyzed pharmacogenomic knowledge among LAC scientific clinical community examined barriers to application. We performed a search for publications trials worldwide evaluated contribution of LAC. Next, conducted...

10.3389/fphar.2023.1175737 article EN cc-by Frontiers in Pharmacology 2023-05-11

In response to COVID-19 pandemic, we have launched a vaccine development program against SARS-CoV-2. Here report the safety, tolerability, and immunogenicity of recombinant protein RBD fusion heterodimeric SARS-CoV-2 (PHH-1V) evaluated in phase 1-2a dose-escalation, randomized clinical trial conducted Catalonia, Spain. 30 young healthy adults were enrolled received two intramuscular doses, 21 days apart PHH-1V formulations [10 µg (n = 5), 20 10), 40 10)] or control [BNT162b2 5)]. Each group...

10.1038/s41541-023-00736-5 article EN cc-by npj Vaccines 2023-09-29

In Nicaragua, there are ideal environmental conditions for leptospirosis. The objective of this investigation was to detect pathogenic and saprophytic leptospires in water soil samples from leptospirosis-endemic areas Nicaragua. Seventy-eight 42 were collected houses rivers close confirmed human cases. Leptospira spp isolated Ellinghausen-McCullough-Johnson-Harris (EMJH) culture medium with 5-fluororacil positive analyzed through PCR the LipL32 gene, specific (P1 clade). There 73 cultures...

10.3390/tropicalmed5030149 article EN cc-by Tropical Medicine and Infectious Disease 2020-09-18

Summary Background We report safety, tolerability, and immunogenicity of a recombinant protein RBD-fusion heterodimeric vaccine against SARS-CoV-2 (PHH-1V). Methods A dose-escalation, phase 1-2a, randomized clinical trial was performed in Catalonia, Spain. Each cohort had one safety sentinel that received PHH-1V the corresponding dose, remaining participants were randomly assigned to receive formulations [10µg (n=5), 20µg (n=10), 40µg (n=10)] or control BNT162b2 (n=5). Two intramuscular...

10.1101/2022.08.09.22278560 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-08-12

Este artículo pretende evidenciar la pluralidad de estrategias argumentativas que usaron los indígenas del Cauca, en inicios siglo XX, para reclamar derechos ciudadanos desde su condición indígenas. El texto se centra tres distintos líderes participaron diferentes maneras las revueltas dieron región entre 1914 y 1917 sus trayectorias políticas. Se destaca importancia rescatar historiográficamente ‘otras voces’, algunas ellas disonantes, existieron época como una forma entender, a partir...

10.1080/17442222.2020.1770974 article ES cc-by Latin American and Caribbean Ethnic Studies 2020-06-17

This article analyzes how cultural translation was carried out in Manuel Quintín Lame’s interpretation of Law 89 1980 during the indigenous revolt that took place Tierradentro – Cauca (Colombia) between 1914 and 1916: riots were popularlyr eferred to as La Quintiada. The main focus here is on Lame his contemporaries’ visions justice regarding possession land a way account for richness complexity »cultural baggage« behind legal transfer processes. purpose this exercise detail extrajuridical...

10.12946/rg24/203-217 article EN cc-by-nc-nd Rechtsgeschichte - Legal History 2016-01-01

Abstract Purpose: Antimicrobial resistance (AMR) in cancer patients increases the frequency of sepsis, mortality and sepsis-associated costs care, being greatest public health threats our time. The prevalence AMR is 40% those admitted to ICU, accounting for direct care at least $20 billion (about $62 per person US). By 2050, infections are expected be leading cause death, but disproportionately impacted, therefore, this study’s objective was determine Gram-negative bacterial (GNB) isolated...

10.1158/1538-7755.asgcr23-abstract-69 article EN Cancer Epidemiology Biomarkers & Prevention 2023-06-01

There has been a gap in knowledge regarding how civil society organisations (CSOs) interact at different levels when working to integrate refugees into the labour market—its causes and limitations. To contribute filling gap, this study employs both rational choice perspective sociological institutionalism analyse why CSOs Jönköping municipality Sweden interacted with other relevant actors, (horizontally) public sector (vertically), market after refugee crisis 2015 what challenges they faced....

10.1080/1369183x.2023.2235900 article EN cc-by-nc-nd Journal of Ethnic and Migration Studies 2023-07-14

CIVIL SOCIETY ENGAGEMENT IN REFUGEE INTEGRATION: SUBJECT TO PRIOR LEARNING AND INSTITUTIONAL CONSTRAINTS

10.21125/iceri.2023.0407 article EN ICERI proceedings 2023-11-01

Juan Carlos Garavaglia, Michael J. Braddick, Christian Lamoureux (eds.), Serve the Power(s), State. America and Eurasia, Newcastle upon Tyne: Cambridge Scholars Publishing 2016, 445 p., ISBN 978-1-4438-8877-6 Recommended citation: Escobar H., Karla L., Sobre los retos de pensar al Estado históricamente, in: Rechtsgeschichte - Legal History Rg 25 (2017) 314-316, online: http://dx.doi.org/10.12946/rg25/314-316

10.12946/rg25/314-316 article EN cc-by-nc-nd Rechtsgeschichte - Legal History 2017-01-01

Introduction:The study of anti-SARS-CoV-2 IgG antibodies allows asymptomatic individuals with COVID-19 to be identified, and post-infection post-vaccination immunity status evaluated.Objective: To know the behavior before after vaccination in workers a cancer center.Methods: Prior application vaccine, presence (n = 171) was analyzed by evaluating anti-N antibodies; post-vaccination, receiving second dose, anti-S were evaluated 60).Results: vaccination, present 18.71% participants; they...

10.24875/gmm.21000674 article EN cc-by-nc-nd Gaceta Médica de México 2022-02-10

The study of anti-SARS-CoV-2 IgG antibodies allows asymptomatic individuals with COVID-19 to be identified, and post-infection post-vaccination immunity status evaluated.To know the behavior before after vaccination in workers a cancer center.Prior application vaccine, presence (n = 171) was analyzed by evaluating anti-N antibodies; post-vaccination, receiving second dose, anti-S were evaluated 60).Prior vaccination, present 18.71% participants; they detected 65.22% those prior history...

10.24875/gmm.m22000645 article ES cc-by-nc-nd Gaceta Médica de México 2022-06-17

Introduction: The Kidney Transplant Program at the Hospital General San Juan de Dios (HGSJDD) began in 1992, to date more than 700 transplants have been performed, of these only 15% were from cadaveric sources. Histocompatibility and Immunogenetics Laboratory, was funded 2012 as part Nephrology Department, back that year tissue typing performed by Complement Dependent Cytotoxicity (CDC), spanning last decade laboratory implemented other techniques anti-HLA antibody analysis, which...

10.1097/01.tp.0000888476.17022.aa article EN Transplantation 2022-09-01

El uso de inhibidores calcineurina, en particular tacrolimus como terapia inmunosupresora se ha generalizado a nivel mundial, permitiendo mejorar la tasa sobrevida del injerto y calidad vida paciente trasplantado. Con el acceso los estudios farmacogenética, grupos trasplante mundial han visto motivados realizar genéticos que permitan interpretar influencia polimorfismos genes mTOR, PPP3CA, FKBP1A, FKBP2, FOXP3, sin embargo, más estudiados población trasplantada para optimizar dosis...

10.36829/63cts.v8i2.1040 article ES cc-by-nc-sa Ciencia Tecnologí­a y Salud 2021-12-12
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